Product image of Knavon (Ketoprofen) supplied by GNH India

Knavon

Active Ingredient:
Ketoprofen
Origin:
EU

Knavon (Ketoprofen)

Ketoprofen, the active ingredient in Knavon, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders.
GNH India supplies Knavon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Ketoprofen acts on inflammatory pathways to provide analgesic and anti‑inflammatory benefits in several common conditions.

  • Mild to moderate pain: reduces pain intensity and improves functional comfort.
  • Rheumatoid arthritis: alleviates joint inflammation and swelling.
  • Osteoarthritis: diminishes joint pain and stiffness.
  • Musculoskeletal pain: eases strain‑related discomfort and improves mobility.

How It Works

  • Ketoprofen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis lowers inflammation, pain signaling, and fever responses at the site of tissue injury.

Side Effects

Ketoprofen may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Peptic ulcer disease or gastrointestinal bleeding.
  • Severe renal impairment or acute kidney injury.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe hypersensitivity reactions including Stevens‑Johnson syndrome.
  • Hepatotoxicity with jaundice or hepatitis.

Precautions & Warnings

Before using Ketoprofen, consider the following safety measures.

  • Assess renal function: avoid use in severe kidney disease.
  • Evaluate gastrointestinal risk: patients with ulcer history should use caution.
  • Monitor cardiovascular status: avoid in uncontrolled hypertension or recent heart events.
  • Review concomitant NSAID or anticoagulant therapy to reduce bleeding risk.
  • Pregnancy and lactation: discuss with a healthcare professional before use.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • High‑dose aspirin: additive renal and gastric adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
  • Diuretics: potential for decreased kidney perfusion.
  • Lithium: NSAIDs can raise lithium serum levels, risking toxicity.

Frequently Asked Questions

Knavon contains ketoprofen, an NSAID that is commonly prescribed for mild to moderate pain, rheumatoid arthritis, osteoarthritis and other musculoskeletal inflammatory conditions. It helps reduce pain intensity, swelling and stiffness associated with these disorders.

Ketoprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. Lower prostaglandin levels lead to reduced inflammation, pain signaling, and fever, providing symptomatic relief.

The specific dose of Knavon is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and overall health. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of ketoprofen in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their healthcare provider before using Knavon.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen shares a similar mechanism with other non‑selective NSAIDs such as ibuprofen and naproxen, but it may have a slightly longer half‑life and stronger analgesic potency in some patients. Choice of NSAID depends on individual response, safety profile and physician preference.

Knavon should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat and direct sunlight to maintain stability.

Knavon is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal discomfort for some patients.

Serious risks include gastrointestinal bleeding or ulceration, severe kidney injury, cardiovascular events such as heart attack or stroke, and rare but severe allergic reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience signs of these conditions.

Knavon should be avoided by individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active peptic ulcer disease, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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