Product image of Knavon Retard (Ketoprofen) supplied by GNH India

Knavon Retard

Active Ingredient:
Ketoprofen
Origin:
EU

Knavon Retard (Ketoprofen)

Ketoprofen, the active ingredient in Knavon Retard, is a Nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It is used to relieve mild to moderate pain and to treat inflammatory conditions such as osteoarthritis, rheumatoid arthritis and other musculoskeletal disorders.

GNH India supplies Knavon Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Ketoprofen acts on inflammatory pathways and is indicated for several painful and inflammatory conditions.

  • Osteoarthritis: reduces joint pain and improves mobility.
  • Rheumatoid arthritis: alleviates inflammation and joint tenderness.
  • Musculoskeletal pain: provides analgesia for strains, sprains and back pain.
  • Acute mild to moderate pain: relieves pain from dental procedures, postoperative settings or injury.

How It Works

  • Ketoprofen reversibly inhibits cyclo‑oxygenase enzymes COX‑1 and COX‑2, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce inflammation, pain signalling and fever, producing its analgesic and anti‑inflammatory effects.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: dyspepsia, nausea or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or failure.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic or anaphylactoid reactions.
  • Hepatic dysfunction with elevated transaminases.

Precautions & Warnings

Before prescribing Ketoprofen, clinicians should consider several safety aspects.

  • Renal function: assess baseline kidney status and monitor during therapy.
  • Gastrointestinal risk: avoid in patients with a history of ulcers or bleeding.
  • Cardiovascular disease: use cautiously in patients with hypertension or heart disease.
  • Concomitant NSAIDs or anticoagulants: increase bleeding risk.
  • Pregnancy and lactation: evaluate risk‑benefit; use only if clearly needed.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
  • High‑dose aspirin or other NSAIDs: increased gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: possible reduction in renal function.
  • Lithium: NSAIDs may raise lithium serum levels.
  • Methotrexate: reduced clearance may lead to toxicity.

Frequently Asked Questions

Knavon Retard contains ketoprofen, an NSAID prescribed to manage mild to moderate pain and inflammation. It is commonly used for osteoarthritis, rheumatoid arthritis, musculoskeletal pain such as sprains or strains, and other acute pain situations where inflammation contributes to discomfort.

Ketoprofen blocks the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which are essential for producing prostaglandins. By reducing prostaglandin synthesis, the drug diminishes the inflammatory response, lowers pain‑signal transmission, and helps control fever.

The exact dosage of Knavon Retard is determined by the prescribing clinician based on the patient’s condition, age, weight, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Ketoprofen is generally avoided during the third trimester of pregnancy because of potential risks to the fetus. Use during any stage of pregnancy or while breastfeeding should only occur if the prescriber judges that the benefits outweigh the risks and after a careful assessment.

To order Knavon Retard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen, the active ingredient in Knavon Retard, has a potency comparable to ibuprofen and naproxen but may offer a longer duration of analgesic effect for some patients. Its safety profile is similar to other NSAIDs, with comparable gastrointestinal and renal considerations, so choice often depends on clinician preference and patient tolerance.

Knavon Retard should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat and direct sunlight to maintain stability and potency.

Knavon Retard is taken orally with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The exact timing and frequency are set by the prescribing healthcare professional.

The most serious risks include gastrointestinal ulceration or bleeding, severe renal impairment, life‑threatening skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Knavon Retard should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe heart failure, uncontrolled hypertension, and in the third trimester of pregnancy. It is also contraindicated in patients with severe renal or hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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