Product image of Kodein (Codeine Phosphate Hemihydrate) supplied by GNH India

Kodein

Active Ingredient:
Codeine Phosphate Hemihydrate
Origin:
EU

Kodein (Codeine Phosphate Hemihydrate)

Codeine, the active ingredient in Kodein, is an opioid analgesic presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to suppress cough in adult patients when other treatments are insufficient. It acts centrally on the nervous system and is available by prescription in the European Union.

GNH India supplies Kodein as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Extractumpharma Co.Ltd.

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Indications & Clinical Uses

Codeine is an opioid analgesic used in the management of pain and cough.

  • Mild to moderate pain: provides analgesia to reduce discomfort.
  • Acute cough: suppresses the cough reflex to improve breathing comfort.
  • Post‑operative discomfort: alleviates short‑term pain after minor procedures.

How It Works

  • Codeine phosphate hemihydrate is converted in the liver to morphine, which binds to mu‑opioid receptors in the central nervous system. Activation of these receptors inhibits the transmission of nociceptive signals and reduces the cough reflex, producing analgesic and antitussive effects.

Side Effects

Codeine may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Constipation: reduced bowel motility.
  • Drowsiness: increased sleepiness.
  • Dizziness: sensation of light‑headedness.
  • Dry mouth: reduced salivation.
  • Vomiting: occasional emesis.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing, potentially life‑threatening.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Dependence or addiction: risk with prolonged use.
  • Low blood pressure: hypotensive episodes.
  • Seizures: rare neurologic events.

Precautions & Warnings

When prescribing or dispensing Codeine, consider the following precautions.

  • Assess renal and hepatic function: adjust use in impairment.
  • Avoid in children under 12 years: not recommended for this age group.
  • Do not combine with CNS depressants: increased sedation and respiratory risk.
  • Use caution in pregnancy: potential fetal risk, consult obstetric guidance.
  • Monitor for signs of dependence: limit duration and dosage.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Codeine can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression.
  • Benzodiazepines: heightened risk of respiratory depression.
  • MAO inhibitors: possible severe hypotension.
  • Other opioid analgesics: additive effect leading to overdose.
  • CYP2D6 inhibitors: increased plasma concentrations of codeine.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may increase drowsiness.
  • SSRIs or SNRIs: rare risk of serotonin syndrome.
  • Diuretics: potential enhancement of hypotensive effect.

Frequently Asked Questions

Kodein contains codeine, which is prescribed to relieve mild to moderate pain and to suppress coughing. It is typically used in adult patients when other analgesics or antitussives are insufficient.

Codeine is metabolized to morphine in the liver; the resulting morphine binds to mu‑opioid receptors in the central nervous system, decreasing the perception of pain and dampening the cough reflex.

The appropriate dose of Kodein is determined by the prescribing clinician based on the patient’s condition, age, weight, and response. Dosage instructions are provided on the prescription label.

Safety of codeine in pregnancy and lactation is not fully established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order Kodein, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Kodein (codeine) is an opioid‑based antitussive, offering stronger cough suppression than non‑opioid agents such as dextromethorphan, but it carries a higher risk of sedation, dependence and respiratory depression, requiring careful patient selection.

Store Kodein at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

Kodein is taken orally, usually as a tablet or liquid, as directed by the prescribing healthcare professional. It should be swallowed whole with water unless the label specifies otherwise.

Serious risks include respiratory depression, severe allergic reactions, dependence or addiction, and profound sedation, especially when combined with other central nervous system depressants.

Kodein should be avoided in children under 12 years, patients with severe respiratory insufficiency, acute or severe asthma, known hypersensitivity to codeine, and in individuals taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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