Product image of Kodein Dak (Codeine Phosphate Sesquihydrate) supplied by GNH India

Kodein Dak

Active Ingredient:
Codeine Phosphate Sesquihydrate
Origin:
EU

Kodein Dak (Codeine Phosphate Sesquihydrate)

Codeine phosphate, the active ingredient in Kodein Dak, is an opioid analgesic presented as an oral formulation for oral use. It is employed to relieve mild to moderate pain and to suppress cough in adult patients when other treatments are insufficient. It is indicated for short‑term use under medical supervision.

GNH India supplies Kodein Dak as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Codeine phosphate acts on the central nervous system to provide analgesic and antitussive effects.

  • Mild to moderate pain: provides relief by reducing the perception of pain.
  • Acute cough: suppresses the cough reflex in respiratory conditions.
  • Post‑operative discomfort: helps manage short‑term discomfort after minor surgical procedures.

How It Works

  • Codeine phosphate is a pro‑drug that is metabolized to morphine, which binds to mu‑opioid receptors in the brain and spinal cord. Activation of these G‑protein‑coupled receptors inhibits adenylate cyclase, reduces calcium influx, and increases potassium efflux, leading to decreased neuronal excitability and diminished transmission of pain and cough signals.

Side Effects

Adverse reactions may occur with codeine phosphate use.

Common Side Effects

  • Nausea: feeling of sickness or urge to vomit.
  • Constipation: reduced bowel movements and hard stools.
  • Drowsiness: increased sleepiness or fatigue.
  • Dizziness: light‑headed sensation or loss of balance.
  • Dry mouth: reduced salivation causing throat discomfort.
  • Itching: mild skin pruritus.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be life‑threatening.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.
  • Dependence or addiction: potential for misuse with prolonged use.
  • Hepatotoxicity: liver injury in rare cases.

Precautions & Warnings

Before prescribing Kodein Dak, clinicians should evaluate patient history and potential risk factors.

  • Assess pain severity: confirm that pain is mild to moderate and suitable for an opioid.
  • Review respiratory status: avoid use in patients with compromised breathing.
  • Check for drug interactions: consider concurrent CNS depressants.
  • Monitor for dependence: limit duration and dosage as appropriate.
  • Avoid in children: not recommended for pediatric use without specialist advice.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Codeine phosphate may interact with other medicines, altering its effect or safety profile.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression risk.
  • Benzodiazepines or barbiturates: enhanced CNS depression.
  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may reduce analgesic conversion.
  • Alcohol: can increase sedation and respiratory effects.
  • Anticholinergics: may worsen constipation.

Frequently Asked Questions

Kodein Dak contains codeine phosphate and is used to treat mild to moderate pain as well as to suppress a troublesome cough. It is typically prescribed for short‑term relief when non‑opioid options are insufficient, and it may also be used to manage post‑operative discomfort in adult patients.

Codeine phosphate is converted in the body to morphine, which binds to mu‑opioid receptors in the central nervous system. This binding reduces the release of neurotransmitters involved in pain signaling and dampens the cough reflex, providing both analgesic and antitussive effects.

The appropriate dose of Kodein Dak is determined by the prescribing clinician based on the individual’s condition, age, weight, and response to therapy. Dosage regimens are not standardized in public information and should follow the prescriber’s instructions and local regulatory guidance.

Safety data for codeine phosphate in pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. It can cross the placenta and appear in breast milk, so healthcare providers usually recommend alternative treatments for pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Kodein Dak. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kodein Dak (codeine phosphate) is a weaker opioid compared with agents such as morphine or oxycodone, offering milder analgesia and a lower risk of severe respiratory depression when used appropriately. However, it still carries potential for dependence and may be less effective for severe pain, where stronger opioids are preferred.

Kodein Dak should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and excessive heat to maintain stability and potency throughout its shelf life.

Kodein Dak is formulated for oral use. The tablet (or oral dosage form) should be swallowed whole with water, unless the prescribing information advises otherwise. It is not intended for crushing, chewing, or sublingual administration.

The most serious risks include respiratory depression, especially when combined with other central nervous system depressants, and the potential for dependence, addiction, or misuse with prolonged therapy. Severe allergic reactions and rare liver toxicity are also possible and require immediate medical attention.

Kodein Dak should be avoided in individuals with known hypersensitivity to codeine or other opioids, those with severe respiratory insufficiency, children without specialist supervision, and patients taking monoamine oxidase inhibitors. It is also contraindicated in patients with significant hepatic impairment or a history of opioid addiction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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