Product image of Kodein Sad (Codeine Phosphate Sesquihydrate) supplied by GNH India

Kodein Sad

Active Ingredient:
Codeine Phosphate Sesquihydrate
Origin:
EU

Kodein Sad (Codeine Phosphate Sesquihydrate)

Codeine phosphate, the active ingredient in Kodein Sad, is an opioid analgesic presented as an oral dosage form for oral use. It provides relief of mild to moderate pain and suppresses cough in adult patients. The medication is formulated for systemic absorption and is commonly prescribed when non‑opioid options are insufficient.

GNH India supplies Kodein Sad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across markets.

Manufacturer / TM Owner

Amgros I/S

1
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Indications & Clinical Uses

Kodein Sad (codeine phosphate) acts on central nervous system pathways to relieve pain and reduce cough.

  • Mild to moderate pain: provides analgesia for acute or chronic pain conditions, improving patient comfort and functional ability.
  • Post‑operative pain: helps control discomfort after surgical procedures, facilitating recovery and mobilization.
  • Cough: suppresses the cough reflex in respiratory irritation, aiding rest and reducing airway stress.

How It Works

  • Codeine phosphate is a pro‑drug that is partially metabolized to morphine, which binds to µ‑opioid receptors in the central nervous system. Activation of these receptors inhibits ascending pain pathways and reduces the excitability of the cough centre in the medulla, resulting in analgesia and cough suppression.

Side Effects

Codeine phosphate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: feeling of stomach upset that may lead to vomiting.
  • Constipation: reduced bowel movements and hard stools.
  • Drowsiness: increased sleepiness or reduced alertness.
  • Dry mouth: decreased salivation causing throat discomfort.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be life‑threatening.
  • Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Dependence or addiction: compulsive use despite harmful consequences.
  • Hypotension: unusually low blood pressure causing dizziness or fainting.

Precautions & Warnings

Before prescribing or dispensing Kodein Sad, consider the following safety measures.

  • Assess pain level and cough severity: ensure the indication justifies opioid therapy.
  • Avoid use in patients with severe respiratory depression: risk of life‑threatening breathing impairment.
  • Monitor for signs of dependence: watch for escalating dose requests or withdrawal symptoms.
  • Use with caution in elderly patients: increased sensitivity to sedation and constipation.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Codeine phosphate can interact with other medicines, altering its effects or increasing risks.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression and profound sedation.
  • Benzodiazepines: heightened central nervous system depression leading to excessive drowsiness.
  • Alcohol: synergistic CNS depression that may impair breathing and cognition.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may increase drowsiness and impair alertness.
  • Selective serotonin reuptake inhibitors (SSRIs): potential for serotonin syndrome when combined.
  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine): can reduce conversion of codeine to morphine, decreasing analgesic effect.

Frequently Asked Questions

Kodein Sad contains codeine phosphate and is used to relieve mild to moderate pain and to suppress coughing. It is prescribed when non‑opioid analgesics or cough suppressants are insufficient, providing systemic relief through central nervous system activity.

Codeine phosphate is partially converted to morphine in the body. The resulting morphine binds to µ‑opioid receptors in the brain and spinal cord, inhibiting pain transmission and reducing the excitability of the cough centre, which together produce analgesic and antitussive effects.

The appropriate dose of Kodein Sad is determined by the prescribing clinician based on the patient’s age, weight, severity of pain or cough, and overall medical condition. Dosage instructions are individualized and should follow the prescriber’s written order.

Safety of codeine phosphate in pregnancy and lactation is not fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision. Breastfeeding mothers should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑opioid antitussives such as dextromethorphan, codeine phosphate offers stronger central cough suppression but carries opioid‑related risks like dependence and respiratory depression. The choice depends on the severity of cough, patient risk factors, and clinical judgment.

Store Kodein Sad at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture, heat and direct sunlight, and keep out of reach of children and unauthorized persons.

Kodein Sad is taken orally, usually with a glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal upset. The exact administration schedule is set by the prescribing clinician.

The most serious risks include respiratory depression, severe allergic reactions, profound sedation, hypotension, and the potential for dependence or addiction. Patients should be monitored closely, especially during initiation or dose escalation, and should seek immediate medical attention if breathing becomes shallow or they experience severe side effects.

Kodein Sad should be avoided in individuals with known hypersensitivity to codeine or other opioids, severe respiratory depression, acute or severe asthma, and in patients taking monoamine oxidase inhibitors (MAOIs) within 14 days. Caution is also advised for the elderly, those with hepatic or renal impairment, and patients with a history of substance misuse.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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