Product image of Kodeinijev Fosfat Alkaloid-Int (Codeine Phosphate Sesquihydrate) supplied by GNH India

Kodeinijev Fosfat Alkaloid-Int

Active Ingredient:
Codeine Phosphate Sesquihydrate
Origin:
EU

Kodeinijev Fosfat Alkaloid-Int (Codeine Phosphate Sesquihydrate)

Codeine phosphate sesquihydrate, the active ingredient in Kodeinijev Fosfat Alkaloid-Int, is an opioid analgesic presented as an oral formulation for systemic use. It is used to treat mild to moderate pain and to suppress cough in appropriate patients.

GNH India supplies Kodeinijev Fosfat Alkaloid-Int as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

Codeine phosphate sesquihydrate is an opioid analgesic that acts on the central nervous system to relieve pain and suppress cough.

  • Mild to moderate pain: provides analgesia to reduce discomfort in acute or chronic settings.
  • Cough associated with upper respiratory infections: suppresses the cough reflex to improve patient comfort.
  • Post‑operative discomfort: alleviates short‑term pain following surgical procedures.

How It Works

  • Codeine phosphate sesquihydrate binds to µ‑opioid receptors in the central nervous system, activating inhibitory G‑protein pathways that decrease neuronal excitability. This receptor activation reduces the perception of pain and diminishes the cough reflex by lowering the sensitivity of the cough center in the medulla.

Side Effects

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Constipation: reduced bowel motility.
  • Drowsiness: increased sleepiness.
  • Dizziness: sensation of light‑headedness.
  • Vomiting: expulsion of stomach contents.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing that may be life‑threatening.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hypotension: marked drop in blood pressure.
  • Seizures: convulsive episodes.
  • Dependence or withdrawal: signs of opioid use disorder.
  • Adrenal insufficiency: rare hormonal imbalance.

Precautions & Warnings

Before prescribing, clinicians should consider several safety factors.

  • Assess pain level: ensure pain is mild to moderate before use.
  • Evaluate respiratory status: avoid in patients with compromised ventilation.
  • Check opioid tolerance: adjust dose if patient is opioid‑experienced.
  • Avoid concurrent CNS depressants: monitor for additive sedation.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25 °C in the original pack, protect from moisture.

Avoid Interactions

Codeine phosphate sesquihydrate may interact with several drug classes.

Major Interactions (Avoid)

  • Other opioids: risk of additive respiratory depression.
  • Benzodiazepines or barbiturates: increased sedation and respiratory risk.
  • MAO inhibitors: can cause severe central nervous system effects.
  • CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.
  • Alcohol: enhances central nervous system depression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce effectiveness.
  • Anticholinergics: may worsen constipation.
  • Antihistamines: may increase drowsiness.
  • SSRIs/SNRIs: potential for serotonin syndrome.
  • Diuretics: may enhance hypotensive effect.

Frequently Asked Questions

Kodeinijev Fosfat Alkaloid-Int contains codeine phosphate sesquihydrate, which is prescribed to relieve mild to moderate pain and to suppress coughing associated with respiratory infections or post‑operative irritation.

The compound acts as an agonist at µ‑opioid receptors in the brain and spinal cord, reducing neuronal firing that conveys pain signals and decreasing the sensitivity of the cough center, thereby providing analgesia and cough suppression.

The appropriate dose is determined by the prescribing clinician based on the patient’s condition, age, weight, and opioid tolerance. Dosage regimens vary and should follow the prescriber’s instructions.

Safety in pregnancy and lactation is not fully established. It should only be used when the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑opioid cough suppressants, codeine offers stronger central cough inhibition but carries opioid‑related risks. As an analgesic, it is less potent than morphine or oxycodone but is suitable for milder pain where stronger opioids are not required.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep out of reach of children and do not use after the expiration date.

Kodeinijev Fosfat Alkaloid-Int is taken orally as directed by the prescriber, usually with a glass of water. It may be taken with or without food, depending on the clinician’s recommendation.

The most critical risks include respiratory depression, severe allergic reactions such as anaphylaxis, profound hypotension, seizures, and the potential for dependence or withdrawal syndrome with prolonged use.

Patients with known hypersensitivity to codeine, severe respiratory insufficiency, acute or severe asthma, paralytic ileus, or those taking MAO inhibitors should avoid this medication. It is also contraindicated in individuals with a history of opioid addiction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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