Product image of Kofituss Mucolitico (Carbocisteine Lysine) supplied by GNH India

Kofituss Mucolitico

Active Ingredient:
Carbocisteine Lysine
Origin:
EU

Kofituss Mucolitico (Carbocisteine Lysine)

Carbocisteine, the active ingredient in Kofituss Mucolitico, is a mucolytic presented as an oral formulation for oral use. It helps reduce thick mucus in the airways of patients with chronic bronchitis, COPD and respiratory infections characterized by excessive sputum, and is marketed in the European Union.

GNH India supplies Kofituss Mucolitico as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Pool-Pharma S.R.L.

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Indications & Clinical Uses

Carbocisteine is used as a mucolytic agent to improve clearance of airway secretions in several respiratory conditions.

  • Chronic bronchitis: facilitates removal of thick sputum, improving cough efficiency.
  • Chronic obstructive pulmonary disease (COPD): reduces mucus viscosity, aiding breathing.
  • Respiratory tract infections with excessive mucus: helps clear secretions, supporting recovery.

How It Works

  • Carbocisteine acts by breaking disulfide bonds within mucopolysaccharide fibers of mucus, thereby decreasing its viscosity and elasticity. The resulting thinner secretions are more easily transported by ciliary action and coughing, enhancing mucociliary clearance from the respiratory tract. Consequently, the drug improves airway patency without affecting smooth‑muscle tone.

Side Effects

Carbocisteine may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset.
  • Vomiting: occasional.
  • Diarrhea: loose stools.
  • Abdominal pain: cramp‑like discomfort.
  • Headache: transient.
  • Skin rash: mild erythema.

Serious or Rare Side Effects

  • Allergic reactions: hives, swelling, or anaphylaxis.
  • Severe gastrointestinal bleeding: uncommon but possible.
  • Hepatotoxicity: rare liver enzyme elevation.
  • Blood dyscrasias: rare blood cell abnormalities.

Precautions & Warnings

When prescribing carbocisteine, several safety considerations should be observed.

  • Pregnancy: use only if clearly needed, as safety data are limited.
  • Breastfeeding: caution advised; monitor infant for adverse effects.
  • Renal impairment: dose adjustment may be required; assess kidney function.
  • Hepatic disease: monitor liver enzymes during therapy.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Carbocisteine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antitussives containing codeine: may reduce mucolytic effect.
  • Highly acidic antacids: can decrease carbocisteine absorption.

Moderate Interactions (Monitor Closely)

  • Bronchodilators (e.g., beta‑agonists): monitor for additive respiratory effects.
  • Antibiotics (e.g., macrolides): observe for potential gastrointestinal synergy.
  • Anticoagulants (e.g., warfarin): watch for altered bleeding risk.

Frequently Asked Questions

Kofituss Mucolitico is indicated for the symptomatic relief of excessive, thick mucus in the airways of patients with chronic bronchitis, chronic obstructive pulmonary disease (COPD) and respiratory tract infections where sputum production is prominent.

Carbocisteine reduces mucus viscosity by cleaving disulfide bonds within mucopolysaccharide fibers. This biochemical action thins the secretions, allowing ciliary movement and coughing to clear the mucus more efficiently from the respiratory tract.

The appropriate dose of Kofituss Mucolitico is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for carbocisteine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To request Kofituss Mucolitico, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Carbocisteine (Kofituss Mucolitico) and N‑acetylcysteine are both mucolytics, but they differ in chemical structure and specific mechanisms. Carbocisteine primarily disrupts disulfide bonds in mucus, while N‑acetylcysteine also provides antioxidant effects. Choice of agent depends on clinical judgment, patient tolerance and local guidelines.

Store Kofituss Mucolitico at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity.

Kofituss Mucolitico is taken orally, usually with a glass of water. It may be taken with or without food, according to the prescriber’s guidance. Swallow the tablet or liquid form whole; do not crush or chew unless specifically instructed.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, significant gastrointestinal bleeding, and rare liver injury. Patients should seek immediate medical attention if they experience symptoms like rash, swelling, difficulty breathing, vomiting blood, or jaundice.

Kofituss Mucolitico should be avoided in individuals with known hypersensitivity to carbocisteine or any excipients in the formulation. Caution is also advised for patients with severe hepatic or renal impairment, and it is generally not recommended for use in newborns without specialist advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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