Product image of Kofituss Sedativo Tosse (Levodropropizine) supplied by GNH India

Kofituss Sedativo Tosse

Active Ingredient:
Levodropropizine
Origin:
EU

Kofituss Sedativo Tosse (Levodropropizine)

Levodropropizine, the active ingredient in Kofituss Sedativo Tosse, is an antitussive presented as an oral formulation for oral use. It provides symptomatic relief of dry, non‑productive coughs in both adults and children, helping to reduce the frequency and intensity of the cough reflex. By acting on peripheral cough receptors, it offers an alternative to centrally acting opioid antitussives and minimizes the likelihood of central nervous system sedation.

GNH India supplies Kofituss Sedativo Tosse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pool-Pharma S.R.L.

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Indications & Clinical Uses

Levodropropizine is used as an oral antitussive to suppress coughs arising from irritation of the respiratory tract.

  • Dry cough: provides symptomatic relief by reducing the cough reflex without affecting mucus clearance.
  • Acute upper respiratory tract infection: helps lessen irritating cough associated with viral or bacterial infections.
  • Non‑productive bronchitis: alleviates persistent cough in bronchial inflammation when sputum production is minimal.

How It Works

  • Levodropropizine acts peripherally on sensory cough receptors located in the airway epithelium. It desensitizes these receptors, decreasing their responsiveness to mechanical and chemical stimuli, which in turn reduces the afferent limb of the cough reflex. Unlike central opioid antitussives, it does not cross the blood‑brain barrier, thereby limiting central nervous system effects. The drug’s peripheral action also preserves normal mucociliary clearance, allowing effective removal of secretions.

Side Effects

Levodropropizine is generally well tolerated, but some patients may experience adverse reactions ranging from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset occurring shortly after ingestion.
  • Headache: transient mild to moderate head pain.
  • Dry mouth: reduced salivation leading to a dry feeling in the mouth.
  • Dizziness: occasional light‑headed sensation, usually resolves without intervention.

Serious or Rare Side Effects

  • Allergic reactions (rash, urticaria): skin eruptions that may require medical attention.
  • Angioedema or facial swelling: rapid swelling of lips, tongue or face, potentially airway‑compromising.
  • Hepatic dysfunction or severe neutropenia: abnormal liver enzymes or low white‑blood‑cell count, requiring laboratory monitoring.

Precautions & Warnings

Levodropropizine should be used with caution in specific populations and conditions.

  • Pregnancy: safety not established; use only if the potential benefit justifies the potential risk.
  • Breastfeeding: unknown excretion; consider possible effects on the infant before use.
  • Renal impairment: dose adjustment may be required; monitor renal function in patients with severe impairment.
  • Concomitant CNS depressants: may increase sedation; observe patients for enhanced drowsiness.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Potential drug interactions with levodropropizine should be reviewed before therapy.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of additive central effects such as excessive sedation.
  • Strong CYP3A4 inhibitors: may increase levodropropizine plasma concentrations.
  • Other antitussives: combined use can lead to excessive cough suppression.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance sedative properties.
  • Antihistamines: can increase drowsiness.
  • Selective serotonin reuptake inhibitors: monitor for rare serotonin‑related effects.

Frequently Asked Questions

Kofituss Sedativo Tosse contains levodropropizine, an oral antitussive indicated for the symptomatic relief of dry and non‑productive coughs. It is used in adults and children to reduce the frequency and intensity of coughing associated with irritation of the respiratory tract, such as in common colds, acute upper respiratory infections, and non‑productive bronchitis.

Levodropropizine works peripherally by desensitizing cough receptors located in the airway epithelium. This reduces the receptors’ response to mechanical and chemical stimuli, thereby lowering the afferent signal that triggers the cough reflex. Because it does not cross the blood‑brain barrier, it avoids central nervous system effects typical of opioid‑based cough suppressants.

The appropriate dose of Kofituss Sedativo Tosse is determined by the prescribing healthcare professional based on the patient’s age, weight, and severity of symptoms. The prescriber will select the formulation strength and dosing frequency that best matches the individual’s therapeutic needs, following local labeling recommendations.

Safety data for levodropropizine in pregnancy and lactation are limited. It should be used only if the potential benefit outweighs any possible risk to the fetus or infant. Healthcare providers typically advise caution and may recommend alternative therapies when safer options are available.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Unlike centrally acting opioid antitussives such as codeine, levodropropizine acts peripherally and does not cause significant sedation or respiratory depression. This makes it a preferable option for patients who need cough relief without the central nervous system side effects associated with opioid‑based products.

Kofituss Sedativo Tosse should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

The medication is taken orally, usually as a tablet or liquid preparation, according to the prescriber’s instructions. It can be swallowed with or without food; if a liquid form is used, it should be measured with a calibrated device to ensure accurate dosing.

Serious adverse reactions, although rare, include allergic responses such as rash, urticaria, angioedema, and in extreme cases anaphylaxis. Hepatic dysfunction and severe neutropenia have also been reported. Patients should seek immediate medical attention if they experience swelling of the face or lips, difficulty breathing, or signs of liver injury.

Individuals with a known hypersensitivity to levodropropizine or any excipients in the formulation should avoid the product. Patients with severe hepatic impairment, uncontrolled asthma, or those taking contraindicated medications (e.g., monoamine oxidase inhibitors) should also refrain from use unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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