Product image of Kofituss Sedativo Tossetosse (Levodropropizine) supplied by GNH India

Kofituss Sedativo Tossetosse

Active Ingredient:
Levodropropizine
Origin:
EU

Kofituss Sedativo Tossetosse (Levodropropizine)

Levodropropizine, the active ingredient in Kofituss Sedativo Tossetosse, is an antitussive presented as an oral formulation for oral use. It is indicated for the symptomatic treatment of dry, non‑productive coughs in both adult and pediatric populations, offering cough relief without central nervous system effects.

GNH India supplies Kofituss Sedativo Tossetosse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, sourcing the product from EU‑registered manufacturers to ensure quality and regulatory compliance.

Manufacturer / TM Owner

Pool-Pharma S.R.L.

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Indications & Clinical Uses

Levodropropizine is an antitussive that acts on peripheral sensory nerves to suppress cough.

  • Dry cough: reduces the frequency and intensity of coughing episodes.
  • Non‑productive cough: alleviates irritation‑driven cough without producing sputum.
  • Cough associated with upper respiratory tract irritation: provides symptomatic relief by dampening the cough reflex.

How It Works

  • Levodropropizine acts peripherally on sensory nerve endings in the respiratory tract. By inhibiting the activation of cough receptors, it reduces afferent signals that trigger the cough reflex. The drug does not cross the blood‑brain barrier, avoiding central nervous system effects while decreasing cough frequency and severity, making it suitable for patients where central agents are contraindicated.

Side Effects

Levodropropizine may be associated with several adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset.
  • Diarrhea: loose stools.
  • Dyspepsia: indigestion or discomfort.
  • Headache: transient mild headache.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or swelling.
  • Anaphylaxis: severe, potentially life‑threatening hypersensitivity.
  • Hepatotoxicity: signs of liver dysfunction.
  • Blood dyscrasias: rare blood count abnormalities.
  • Severe skin reactions: Stevens‑Johnson syndrome.

Precautions & Warnings

When prescribing Levodropropizine, consider the following precautions.

  • Use in children: follow prescriber guidance, dosage based on age and weight.
  • Renal impairment: consider dose adjustment if renal function is reduced.
  • Hepatic impairment: monitor liver function, adjust if necessary.
  • Concomitant CNS depressants: no significant interaction, but monitor for additive sedation.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Levodropropizine has a limited interaction profile, but certain combinations require attention.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may increase risk of hypertensive reactions.
  • Anticholinergic drugs: potential additive anticholinergic effects.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may enhance sedative sensations.
  • NSAIDs: monitor for gastrointestinal irritation.
  • Other cough suppressants: risk of additive cough suppression.
  • Alcohol: may increase dizziness or gastrointestinal upset.

Frequently Asked Questions

Kofituss Sedativo Tossetosse contains levodropropizine, an oral antitussive used to relieve dry and non‑productive coughs. It targets peripheral cough receptors in the respiratory tract, providing symptomatic relief without affecting the central nervous system, making it suitable for patients who need a non‑sedating cough suppressant.

Levodropropizine works by inhibiting sensory nerve endings in the airways that trigger the cough reflex. By blocking these peripheral receptors, the drug reduces the afferent signals that lead to coughing, offering effective cough suppression while avoiding central nervous system activity.

The appropriate dose of Kofituss Sedativo Tossetosse is determined by a qualified healthcare professional based on the patient’s age, weight, and clinical condition. Prescribers set the exact regimen, and patients should follow the instructions provided on the prescription label.

Safety data for levodropropizine during pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers should evaluate each case individually before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details and any required import documentation.

Unlike central agents such as codeine, levodropropizine acts peripherally and does not cause sedation or respiratory depression. This makes it a preferable option for patients who need cough relief without the risk of opioid‑related side effects, especially in populations where central depressants are contraindicated.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging to protect from moisture and light. Do not refrigerate or freeze the medication, and ensure the container is tightly closed when not in use.

The medication is taken orally. Patients should swallow the tablet or liquid formulation whole with water, following the dosage instructions provided by their healthcare professional. It is not intended for sublingual or rectal administration.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, skin conditions like Stevens‑Johnson syndrome, and signs of liver injury. Patients should seek immediate medical attention if they experience rash, swelling, difficulty breathing, or jaundice.

Individuals with known hypersensitivity to levodropropizine or any excipients in the formulation should avoid the product. It is also contraindicated in patients with severe hepatic impairment until safety is established, and should be used with caution in pregnant or nursing women only when clearly indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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