Product image of Kolekalciferol Evolan (Colecalciferol) supplied by GNH India

Kolekalciferol Evolan

Active Ingredient:
Colecalciferol
Origin:
EU

Kolekalciferol Evolan (Colecalciferol)

Colecalciferol, the active ingredient in Kolekalciferol Evolan, is a Vitamin D presented as an oral supplement for oral use. It is used to treat vitamin D deficiency and related bone disorders in children and adults. By enhancing calcium and phosphate absorption, it supports normal bone mineralisation and helps prevent conditions such as osteomalacia and rickets.

GNH India supplies Kolekalciferol Evolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Kolekalciferol Evolan, a vitamin D supplement, is indicated for conditions related to impaired calcium metabolism.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels to support calcium balance.
  • Osteomalacia: promotes bone mineralisation and reduces bone pain in adults.
  • Rickets: aids proper bone growth and prevents skeletal deformities in children.
  • Prevention of bone loss: supports maintenance of bone health in at‑risk populations.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and subsequently in the kidney to the active hormone 1,25‑dihydroxyvitamin D. The active form binds to intracellular vitamin D receptors, forming a complex that regulates gene transcription, increasing intestinal absorption of calcium and phosphate and facilitating bone mineralisation.

Side Effects

Oral colecalciferol may be associated with a range of adverse reactions, most of which are dose‑related.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Constipation: reduced bowel movements.
  • Dry mouth: sensation of oral dryness.
  • Headache: mild to moderate head discomfort.

Serious or Rare Side Effects

  • Hypercalcemia: elevated blood calcium causing weakness, confusion, or cardiac arrhythmia.
  • Kidney stones: calcium deposition in the renal tract.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

When using Kolekalciferol Evolan, several safety considerations should be observed.

  • Baseline calcium assessment: check serum calcium before initiating therapy.
  • Renal function monitoring: evaluate kidney function periodically.
  • Avoid in hypercalcemia: discontinue if serum calcium is high.
  • Caution in granulomatous diseases: conditions such as sarcoidosis may increase vitamin D activation.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Colecalciferol can affect or be affected by other medicines.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • High-dose vitamin A: synergistic hypercalcemia risk.
  • Calcium supplements: excessive calcium load can cause hypercalcemia.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): may reduce vitamin D effectiveness.
  • Glucocorticoids: can impair vitamin D metabolism.
  • Bariatric surgery or malabsorption syndromes: may decrease absorption of oral vitamin D.

Frequently Asked Questions

Kolekalciferol Evolan is an oral vitamin D (colecalciferol) product used to correct vitamin D deficiency, prevent or treat osteomalacia in adults, rickets in children, and to support overall bone health by improving calcium and phosphate balance.

Colecalciferol is first hydroxylated in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors in target cells, enhancing transcription of genes that increase intestinal absorption of calcium and phosphate, which are essential for bone mineralisation.

The appropriate dose of Kolekalciferol Evolan is determined by a qualified healthcare professional based on the patient’s age, serum vitamin D level, underlying condition, and individual response. The prescriber will set the exact regimen and duration.

Safety data for colecalciferol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under the guidance of a healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kolekalciferol Evolan contains colecalciferol, the same form of vitamin D found in most oral supplements and fortified foods. Compared with ergocalciferol (vitamin D2), colecalciferol generally provides more consistent and longer‑lasting increases in serum 25‑hydroxyvitamin D levels.

Store the product at temperatures below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Do not store in a refrigerator or freezer unless the label specifically indicates otherwise.

Kolekalciferol Evolan is taken orally, usually with or without food, as directed by the prescribing clinician. The exact route (tablet, capsule, or liquid) will be indicated on the product label.

The most serious risks include hypercalcemia, which can cause weakness, confusion, cardiac arrhythmias, and kidney stone formation. Rarely, severe allergic reactions such as anaphylaxis may occur. Patients should be monitored for signs of elevated calcium levels.

Individuals with known hypersensitivity to colecalciferol or any excipients, patients with existing hypercalcemia, and those with certain granulomatous diseases (e.g., sarcoidosis) should avoid using the product unless advised otherwise by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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