Product image of Kolekalciferol Teva (Colecalciferol) supplied by GNH India

Kolekalciferol Teva

Active Ingredient:
Colecalciferol
Origin:
EU

Kolekalciferol Teva (Colecalciferol)

Colecalciferol, the active ingredient in Kolekalciferol Teva, is a vitamin D presented as an oral tablet for oral use. It is used to treat vitamin D deficiency, support bone health, and prevent disorders such as rickets and osteomalacia in children and adults.

GNH India supplies Kolekalciferol Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Kolekalciferol Teva provides vitamin D supplementation for conditions related to calcium metabolism and bone health.

  • Vitamin D deficiency: restores normal serum 25‑hydroxyvitamin D concentrations.
  • Bone health maintenance: supports calcium absorption for healthy bone mineralization.
  • Prevention of rickets: averts impaired bone development in children.
  • Prevention of osteomalacia: reduces risk of softening of bones in adults.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and subsequently in the kidneys to the active hormone 1,25‑dihydroxyvitamin D. The active form binds to vitamin D receptors in intestinal cells, enhancing transcription of calcium‑binding proteins, which increases intestinal absorption of calcium and phosphate, thereby promoting bone mineralization and maintaining serum calcium homeostasis.

Side Effects

Kolekalciferol Teva is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Hypercalcemia: mild elevation of blood calcium levels.
  • Nausea: occasional stomach discomfort.
  • Constipation: reduced bowel movements.
  • Headache: transient head pain.
  • Fatigue: feeling of tiredness.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe hypercalcemia: may cause cardiac arrhythmia or renal impairment.
  • Renal stones: calcium deposits in kidneys.
  • Allergic reaction: rash, itching, or swelling.
  • Hypervitaminosis D: toxicity from excessive intake.
  • Hyperphosphatemia: elevated phosphate levels.
  • Anaphylaxis: rare life‑threatening allergic response.

Precautions & Warnings

Before initiating therapy with Kolekalciferol Teva, consider the following precautions.

  • Baseline assessment: measure serum calcium and 25‑hydroxyvitamin D levels.
  • Monitor therapy: repeat laboratory tests periodically to avoid excess.
  • Renal disease: use with caution in patients with impaired kidney function.
  • Sarcoidosis or granulomatous disease: avoid high doses due to risk of hypercalcemia.
  • Concomitant calcium supplements: adjust dose to prevent overdose.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Kolekalciferol Teva may interact with several medicines; awareness of the interaction level helps guide safe use.

Major Interactions (Avoid)

  • Thiazide diuretics: increase risk of hypercalcemia.
  • High‑dose calcium supplements: may cause calcium overload.
  • Vitamin A excess: potentiates vitamin D toxicity.
  • Alendronate: concurrent use may reduce absorption of both agents.
  • Antacids containing aluminum or magnesium: decrease vitamin D absorption.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): accelerate vitamin D metabolism.
  • Glucocorticoids: may reduce vitamin D effectiveness.
  • Orlistat: can impair absorption of fat‑soluble vitamins.
  • Bariatric surgery patients: altered absorption may require monitoring.
  • Cholestyramine: may bind vitamin D and lower its bioavailability.

Frequently Asked Questions

Kolekalciferol Teva is an oral vitamin D supplement used to correct vitamin D deficiency, support normal bone mineralization, and prevent conditions such as rickets in children and osteomalacia in adults. It helps maintain adequate calcium and phosphate levels essential for skeletal health.

Colecalciferol (vitamin D3) is first hydroxylated in the liver to 25‑hydroxyvitamin D, then in the kidneys to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to nuclear vitamin D receptors, increasing transcription of calcium‑binding proteins in the intestine, which enhances calcium and phosphate absorption and promotes bone mineralization.

The appropriate dose of Kolekalciferol Teva is determined by a qualified healthcare professional based on the individual’s serum vitamin D level, age, clinical condition, and any concomitant medications. Patients should follow the prescriber’s instructions and not self‑adjust the dosage.

Safety data for colecalciferol in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. Healthcare providers should evaluate the risk‑benefit ratio before prescribing it to pregnant or nursing women, and use the lowest effective dose if deemed necessary.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.

Kolekalciferol Teva contains colecalciferol (vitamin D3), which is the natural form of vitamin D produced in skin after sunlight exposure and is generally considered more potent and longer‑acting than vitamin D2 (ergocalciferol). Its efficacy in raising serum 25‑hydroxyvitamin D levels is comparable to other high‑quality D3 supplements, while formulation and regulatory status may differ.

Store Kolekalciferol Teva at temperatures below 25 °C in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments to maintain stability and potency.

Kolekalciferol Teva is taken orally, usually with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water. Patients should not crush or chew the tablet unless specifically instructed.

The most serious risks include severe hypercalcemia, which can lead to cardiac arrhythmias, renal failure, or vascular calcification, and hypervitaminosis D resulting from excessive dosing. Patients should be monitored for symptoms such as persistent nausea, vomiting, weakness, or abnormal laboratory values and seek medical attention if they occur.

Individuals with known hypersensitivity to colecalciferol or any excipients in the formulation should avoid the product. Patients with conditions predisposing them to hypercalcemia, such as sarcoidosis, primary hyperparathyroidism, or severe renal impairment, should use it only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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