Product image of Kombi-Kalz (Colecalciferol, Calcium) supplied by GNH India

Kombi-Kalz

Active Ingredient:
Colecalciferol, Calcium
Origin:
EU

Kombi-Kalz (Colecalciferol, Calcium)

Colecalciferol and calcium, the active ingredients in Kombi-Kalz, are a vitamin D3 and calcium supplement presented as an oral tablet for oral use. It helps prevent and treat vitamin D and calcium deficiencies in adults and children at risk of bone health problems.

GNH India supplies Kombi-Kalz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Kombi‑Kalz is used to address deficiencies in the vitamin D and calcium pathways, supporting bone health and mineral balance.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels to support calcium absorption.
  • Calcium deficiency: provides elemental calcium to maintain normal serum calcium concentrations.
  • Osteoporosis risk: contributes to bone mineralization and helps reduce bone loss in individuals at risk.

How It Works

  • Colecalciferol (vitamin D3) is converted in the liver to 25‑hydroxyvitamin D and subsequently in the kidney to the active hormone calcitriol, which binds to vitamin D receptors in intestinal cells to increase transcription of calcium‑binding proteins, enhancing calcium absorption. The supplied calcium provides the mineral substrate required for bone matrix formation and for maintaining extracellular calcium homeostasis.

Side Effects

Kombi‑Kalz may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset after ingestion.
  • Constipation: reduced bowel movements.
  • Hypercalcemia symptoms: occasional fatigue or mild headache.
  • Metallic taste: transient alteration in taste perception.
  • Skin rash: mild erythema at the site of contact.

Serious or Rare Side Effects

  • Severe hypercalcemia: confusion, arrhythmia, or renal impairment.
  • Allergic reaction: swelling of face, lips, or throat.
  • Kidney stones: due to excess calcium excretion.
  • Hypervitaminosis D: persistent vomiting, weakness, or high blood pressure.

Precautions & Warnings

Before using Kombi‑Kalz, consider the following safety measures.

  • Renal impairment: monitor serum calcium and vitamin D levels.
  • Hypercalcemia history: avoid if previously diagnosed with high calcium.
  • Sarcoidosis or granulomatous disease: use with caution due to altered vitamin D metabolism.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Drug interactions: review concomitant medications for calcium or vitamin D interactions.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Kombi‑Kalz can affect the absorption or activity of several medicines.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • Digoxin: elevated calcium can enhance digoxin toxicity.
  • High‑dose vitamin A: synergistic hypercalcemia risk.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may reduce calcium absorption.
  • Orlistat: can decrease absorption of fat‑soluble vitamin D.
  • Corticosteroids: may counteract calcium and vitamin D benefits on bone.

Frequently Asked Questions

Kombi‑Kalz is an oral nutritional supplement that provides both colecalciferol (vitamin D3) and calcium. It is used to prevent or treat vitamin D deficiency, calcium deficiency, and to support bone health in individuals at risk of osteoporosis or low bone mineral density.

Colecalciferol is converted in the body to the active hormone calcitriol, which binds to vitamin D receptors in the intestine. This binding increases the production of calcium‑binding proteins, enhancing calcium absorption from the gut and helping maintain normal serum calcium levels for bone mineralization.

The appropriate dose of Kombi‑Kalz is determined by a qualified healthcare professional based on the patient’s age, nutritional status, laboratory results, and clinical condition. Prescribers tailor the regimen to achieve optimal vitamin D and calcium levels.

Pregnant or breastfeeding individuals should consult their physician before starting Kombi‑Kalz. Vitamin D and calcium are essential nutrients during these periods, but dosing must be individualized to avoid excess calcium or vitamin D, which could affect maternal and fetal health.

To order Kombi‑Kalz, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kombi‑Kalz combines both colecalciferol and calcium in a single oral formulation, offering convenience over separate supplements. Compared with products that contain only vitamin D or calcium, Kombi‑Kalz ensures simultaneous delivery of both nutrients, which may improve compliance and synergistic bone‑support effects.

Store Kombi‑Kalz at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

Kombi‑Kalz is taken orally, usually with a glass of water. It can be taken with or without food, but consistent administration with meals may improve calcium absorption. Follow the dosing instructions provided by the prescribing healthcare professional.

The most serious risks include hypercalcemia, which can cause confusion, cardiac arrhythmias, or kidney stones, and allergic reactions such as facial swelling or difficulty breathing. Patients experiencing these symptoms should seek immediate medical attention.

Individuals with known hypersensitivity to colecalciferol, calcium, or any excipients in the tablet should avoid Kombi‑Kalz. It is also contraindicated in patients with untreated hypercalcemia, severe renal impairment, or certain granulomatous diseases unless closely monitored by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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