Product image of Kombi-Kalz (Colecalciferol, Calcium) supplied by GNH India

Kombi-Kalz

Active Ingredient:
Colecalciferol, Calcium
Origin:
EU

Kombi-Kalz (Colecalciferol, Calcium)

Colecalciferol, the active ingredient in Kombi-Kalz, is a Vitamin D3 and calcium supplement presented as an oral dosage form for oral use. It helps address calcium and vitamin D deficiencies and supports bone health in individuals at risk of osteopenia or osteoporosis.

GNH India supplies Kombi-Kalz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets. The company adheres to EU GMP standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Kombi-Kalz is a nutritional supplement that acts on calcium and vitamin D pathways to correct deficiencies and support skeletal health.

  • Calcium deficiency: restores normal calcium levels and promotes bone mineralization.
  • Vitamin D deficiency: supplies colecalciferol to improve serum 25‑OH vitamin D concentrations.
  • Bone health maintenance: assists in maintaining bone density and reducing risk of osteoporotic fractures.
  • Osteopenia risk management: provides essential nutrients to support bone remodeling in at‑risk adults.
  • Post‑menopausal bone support: helps counteract accelerated bone loss associated with menopause.

How It Works

  • Colecalciferol (vitamin D3) is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D, which binds to nuclear vitamin D receptors in intestinal cells, enhancing transcription of calcium‑binding proteins and increasing calcium absorption. The elemental calcium supplied directly contributes to the calcium pool needed for hydroxyapatite formation during bone mineralization.

Side Effects

Kombi-Kalz may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: occasional mild stomach upset.
  • Constipation: transient changes in bowel movements.
  • Flatulence: increased intestinal gas.
  • Headache: mild, self‑limiting.
  • Metallic taste: brief alteration in taste perception.

Serious or Rare Side Effects

  • Hypercalcemia: elevated blood calcium levels, potentially causing weakness or cardiac arrhythmia.
  • Kidney stones: calcium precipitation in the urinary tract.
  • Allergic reaction: rash, itching, or swelling of the face, lips, or tongue.
  • Hypervitaminosis D: excessive vitamin D leading to toxicity symptoms.
  • Severe gastrointestinal bleeding: rare but serious abdominal pain with blood loss.

Precautions & Warnings

Before initiating Kombi-Kalz, consider the following safety measures.

  • Baseline assessment: evaluate serum calcium and 25‑OH vitamin D levels.
  • Renal function: monitor kidney function in patients with chronic kidney disease.
  • Hypercalcemia risk: avoid use in individuals with known hypercalcemia or hyperparathyroidism.
  • Sarcoidosis caution: vitamin D may exacerbate calcium accumulation in granulomatous diseases.
  • Pregnancy and lactation: use only if the prescriber determines potential benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Kombi-Kalz can interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • Vitamin A excess: combined high doses can precipitate hypercalcemia.
  • Digoxin: elevated calcium may enhance digoxin toxicity.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (phenytoin, phenobarbital): accelerate vitamin D metabolism, reducing efficacy.
  • Glucocorticoids: diminish calcium absorption and increase urinary calcium loss.
  • Bisphosphonates: concurrent use may affect calcium balance; monitor serum levels.

Frequently Asked Questions

Kombi-Kalz is an oral nutritional supplement that provides colecalciferol (vitamin D3) and elemental calcium. It is used to correct calcium and vitamin D deficiencies and to support bone health, particularly in individuals at risk of osteopenia, osteoporosis, or related metabolic bone disorders.

Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and then in the kidneys to the active hormone 1,25‑dihydroxyvitamin D. This hormone binds to vitamin D receptors in intestinal cells, increasing the synthesis of calcium‑binding proteins and thereby enhancing calcium absorption from the gut.

The appropriate dose of Kombi-Kalz is determined by the prescribing healthcare professional based on the patient’s individual calcium and vitamin D status, age, renal function, and clinical condition. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Kombi-Kalz in pregnancy and lactation are limited. It should only be used if the prescriber judges that the potential benefit outweighs any possible risk to the mother or infant. Women who are pregnant or breastfeeding should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Kombi-Kalz combines colecalciferol and calcium in a single oral formulation, offering convenience over separate supplements. Compared with products that contain only calcium or only vitamin D, Kombi‑Kalz ensures coordinated delivery of both nutrients, which can improve absorption efficiency and simplify dosing regimens.

Kombi‑Kalz should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed to maintain stability.

Kombi‑Kalz is taken orally, usually with water. The tablet (or other oral dosage form) should be swallowed whole unless the prescriber advises otherwise. It can be taken with or without food, but consistent administration with respect to meals may help maintain stable absorption.

The most serious risks include hypercalcemia, which can cause weakness, cardiac arrhythmias, and kidney stones, as well as rare allergic reactions such as rash, swelling, or anaphylaxis. Patients should seek medical attention if they experience symptoms like persistent vomiting, severe abdominal pain, or signs of an allergic response.

Kombi‑Kalz should be avoided in individuals with known hypercalcemia, severe renal impairment, active sarcoidosis or other granulomatous diseases, and those who are hypersensitive to any component of the product. Pregnant or breastfeeding women should only use it under direct medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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