Product image of Kombi-Kalz (Colecalciferol, Calcium Carbonate) supplied by GNH India

Kombi-Kalz

Active Ingredient:
Colecalciferol, Calcium Carbonate
Origin:
EU

Kombi-Kalz (Colecalciferol, Calcium Carbonate)

Colecalciferol and Calcium carbonate, the active ingredients in Kombi-Kalz, are a vitamin D and calcium supplement presented as an oral tablet for oral use. They help correct vitamin D and calcium deficiencies and support bone health in adults and children at risk of low mineral intake.

GNH India supplies Kombi-Kalz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution. This enables reliable access to the product in diverse markets.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Kombi‑Kalz is used to address nutritional deficiencies of calcium and vitamin D, supporting skeletal health.

  • Calcium deficiency: helps restore normal calcium levels and promotes bone mineralization.
  • Vitamin D deficiency: provides vitamin D3 to enhance intestinal calcium absorption.
  • Osteopenia risk: supports bone density maintenance in individuals at risk of bone loss.

How It Works

  • Colecalciferol (vitamin D3) is metabolized to 25‑hydroxyvitamin D in the liver and then to the active hormone 1,25‑dihydroxyvitamin D in the kidney, which binds to intestinal vitamin D receptors and up‑regulates calcium‑transport proteins, increasing calcium absorption. Calcium carbonate supplies elemental calcium that is absorbed in the small intestine, providing the mineral substrate required for bone mineralization and other physiological functions.

Side Effects

Oral administration of Kombi‑Kalz may be associated with several adverse reactions, ranging from mild to rare serious events.

Common Side Effects

  • Nausea: mild stomach upset.
  • Constipation: reduced bowel movements.
  • Flatulence: increased intestinal gas.
  • Hypercalcemia symptoms: mild fatigue or headache.

Serious or Rare Side Effects

  • Hypercalcemia: severe elevated calcium levels causing confusion, arrhythmia, or cardiac issues.
  • Kidney stones: calcium precipitation in the renal tract.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Hypervitaminosis D: toxicity leading to vomiting, weakness, and severe metabolic disturbances.

Precautions & Warnings

Before using Kombi‑Kalz, consider the following precautions to ensure safe and effective therapy.

  • Assess calcium status: evaluate serum calcium before initiating therapy.
  • Monitor vitamin D levels: periodic testing helps avoid excess.
  • Renal impairment: adjust use in patients with reduced kidney function.
  • Hyperparathyroidism: use with caution as calcium metabolism is altered.
  • Concomitant calcium‑binding drugs: avoid simultaneous use as they may reduce absorption.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Kombi‑Kalz can interact with other medicines; awareness of these interactions helps prevent reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • Vitamin D analogues: additive effect leading to excess calcium.
  • Calcium carbonate with iron supplements: reduces iron absorption.

Moderate Interactions (Monitor Closely)

  • Bisphosphonates: calcium may interfere with absorption; separate dosing by at least 2 hours.
  • Antacids containing aluminum or magnesium: may affect calcium uptake.
  • Corticosteroids: may increase calcium loss, requiring monitoring.

Frequently Asked Questions

Kombi‑Kalz is a nutritional supplement that provides vitamin D3 (colecalciferol) and calcium carbonate. It is intended to correct calcium and vitamin D deficiencies and to support normal bone health in individuals who have low dietary intake or increased physiological needs.

Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors in intestinal cells, stimulating the production of calcium‑binding proteins that increase calcium absorption from the gut.

The appropriate dose of Kombi‑Kalz is determined by a qualified healthcare professional based on the patient’s age, laboratory values, and clinical condition. Prescribers set the regimen to achieve optimal calcium and vitamin D status while avoiding excess.

Safety data for kombi‑Kalz in pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit ratio for each individual. If supplementation is required, the prescriber will choose a dose that meets maternal and fetal needs while minimizing potential adverse effects.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Kombi‑Kalz combines colecalciferol and calcium carbonate in a single oral tablet, offering a convenient dual‑nutrient approach. Compared with separate calcium and vitamin D supplements, it reduces pill burden and ensures coordinated dosing, while the carbonate form provides a high elemental calcium content that is well‑absorbed when taken with food.

Store Kombi‑Kalz at ambient temperature, preferably below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Kombi‑Kalz is taken orally, usually with a meal to enhance calcium absorption. The tablet should be swallowed whole with water unless the prescriber provides alternative instructions.

The most serious risks include hypercalcemia, which can cause confusion, cardiac arrhythmias, and kidney stones, as well as rare cases of severe allergic reactions. Monitoring serum calcium and vitamin D levels helps mitigate these risks.

Individuals with known hypersensitivity to colecalciferol, calcium carbonate, or any excipients should avoid the product. Patients with severe hypercalcemia, uncontrolled hyperparathyroidism, or certain renal disorders should not use Kombi‑Kalz without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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