Product image of Konakion Mm Ampoules (Phytomenadione) supplied by GNH India

Konakion Mm Ampoules

Active Ingredient:
Phytomenadione
Origin:
EU

Konakion Mm Ampoules (Phytomenadione)

Phytomenadione, the active ingredient in Konakion Mm Ampoules, is a vitamin K presented as an injectable solution for intravenous or oral use. It is employed to correct vitamin K deficiency and to support normal clotting in patients at risk of bleeding, including newborns and individuals on anticoagulant therapy.

GNH India supplies Konakion Mm Ampoules as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Konakion Mm provides vitamin K supplementation to address disorders of the coagulation cascade.

  • Vitamin K deficiency: restores functional clotting factor activity in deficient patients.
  • Hemorrhagic disease of the newborn: prevents bleeding in neonates at risk.
  • Anticoagulation reversal: counteracts the effects of warfarin or other vitamin K antagonists.
  • Liver‑related coagulopathy: supports clot formation in patients with impaired hepatic synthesis of clotting factors.

How It Works

  • Phytomenadione acts as an essential cofactor for the gamma‑carboxylation of glutamate residues on clotting factors II, VII, IX, X and the regulatory proteins C and S. This post‑translational modification enables the calcium‑dependent binding of these proteins to phospholipid surfaces, thereby restoring their functional activity and allowing normal thrombin generation and fibrin clot formation.

Side Effects

Adverse reactions may occur following administration of Konakion Mm Ampoules.

Common Side Effects

  • Injection site pain or erythema.
  • Transient flushing or warmth.
  • Mild hypotension.
  • Nausea or vomiting.
  • Headache.

Serious or Rare Side Effects

  • Anaphylactic reaction, including urticaria and respiratory distress.
  • Thrombosis or embolic events.
  • Severe hemolysis (rare).

Precautions & Warnings

Use Konakion Mm with appropriate clinical monitoring and consideration of patient-specific factors.

  • Hepatic impairment: assess coagulation status before administration.
  • Concurrent anticoagulants: monitor INR or PT closely.
  • Neonates: use age‑appropriate dosing and monitor for hyperbilirubinemia.
  • Pregnancy: safety not established; use only if benefit outweighs potential risk.
  • Known hypersensitivity: avoid administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Phytomenadione may interact with several medications affecting coagulation.

Major Interactions (Avoid)

  • Warfarin: may reduce anticoagulant effect, requiring dose adjustment.
  • Broad‑spectrum antibiotics (e.g., cephalosporins): can interfere with vitamin K synthesis and alter efficacy.

Moderate Interactions (Monitor Closely)

  • Heparin: additive anticoagulant effect may increase bleeding risk.
  • Oral contraceptives: potential increased risk of thrombosis.
  • Other vitamin K‑containing products: may modify therapeutic response.

Frequently Asked Questions

Konakion Mm Ampoules contain phytomenadione, a form of vitamin K, and are used to treat vitamin K deficiency, prevent hemorrhagic disease in newborns, reverse the effects of vitamin K antagonists such as warfarin, and support clotting in patients with liver‑related coagulopathy.

Phytomenadione serves as a cofactor for the gamma‑carboxylation of specific clotting factors, enabling them to bind calcium and phospholipid surfaces. This biochemical step restores the functional activity of factors II, VII, IX, X and proteins C and S, facilitating normal blood clot formation.

The dose of Konakion Mm Ampoules is determined by the prescribing healthcare professional based on the patient’s clinical condition, age, weight, and laboratory values. Dosage regimens are individualized and should follow local clinical guidelines.

Safety data for phytomenadione in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother or infant outweighs any possible risk, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Konakion Mm provides phytomenadione in a sterile ampoule suitable for intravenous administration, offering rapid correction of deficiency. Compared with oral vitamin K tablets, the injectable form achieves faster plasma levels, which is advantageous in emergency reversal of anticoagulation or in neonates unable to take oral medication.

Konakion Mm Ampoules should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

The ampoule is intended for intravenous injection by a qualified healthcare professional. It may be diluted in compatible IV fluids according to the prescribing information and administered slowly to reduce the risk of adverse reactions.

Serious adverse events include anaphylactic reactions, which can present with urticaria, respiratory distress, or hypotension, and rare thrombotic complications. Immediate medical attention is required if any signs of severe allergy or unexpected clot formation occur.

Patients with a known hypersensitivity to phytomenadione or any component of the formulation should avoid using Konakion Mm. Caution is also advised in individuals with severe liver disease, uncontrolled bleeding disorders, or those receiving multiple anticoagulant agents without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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