Product image of Konakion Mm Paediatric (Phytomenadione) supplied by GNH India

Konakion Mm Paediatric

Active Ingredient:
Phytomenadione
Origin:
EU

Konakion Mm Paediatric (Phytomenadione)

Phytomenadione, the active ingredient in Konakion Mm Paediatric, is a Vitamin K presented as a paediatric formulation for intramuscular, intravenous, and oral use. It treats vitamin K deficiency, helps prevent hemorrhage in newborns, and reverses anticoagulant therapy in children.
GNH India supplies Konakion Mm Paediatric as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Neon Healthcare Limited

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Indications & Clinical Uses

Konakion Mm Paediatric, a Vitamin K analogue, is used in conditions related to impaired coagulation.

  • Vitamin K deficiency: restores normal clotting factor activity in deficient patients.
  • Prevention of hemorrhage in newborns: provides prophylactic vitamin K to reduce risk of neonatal bleeding.
  • Reversal of anticoagulant therapy: supplies vitamin K to counteract the effects of warfarin and other vitamin K antagonists.

How It Works

  • Phytomenadione acts as a cofactor for the enzyme gamma‑glutamyl carboxylase, enabling the carboxylation of glutamate residues on clotting factors II, VII, IX and X. This post‑translational modification is essential for the calcium‑dependent activation of these factors, thereby restoring normal coagulation pathways.

Side Effects

Adverse reactions may occur with any route of administration.

Common Side Effects

  • Injection site pain or erythema.
  • Mild fever or chills.
  • Nausea or vomiting.
  • Diarrhea.
  • Transient headache.
  • Local swelling.

Serious or Rare Side Effects

  • Anaphylactic reaction or severe hypersensitivity.
  • Hemolysis or severe anemia.
  • Thrombosis or paradoxical clot formation.
  • Severe bleeding despite therapy.
  • Elevated liver enzymes.
  • Acute renal impairment.

Precautions & Warnings

Use with clinical judgment and monitor patients closely.

  • Assess vitamin K status before initiating therapy.
  • Monitor coagulation parameters (PT/INR) during treatment.
  • Use with caution in patients with hepatic impairment.
  • Avoid in individuals with known hypersensitivity to phytomenadione.
  • Follow neonatal dosing guidelines when used for newborn prophylaxis.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Phytomenadione may alter the effect of several drugs.

Major Interactions (Avoid)

  • Coumarin anticoagulants (e.g., warfarin): may reduce anticoagulant effect.
  • Broad‑spectrum antibiotics that disrupt gut flora: can increase vitamin K deficiency risk.
  • Cholestyramine or other bile‑acid sequestrants: may decrease absorption of vitamin K.

Moderate Interactions (Monitor Closely)

  • Rifampin: may increase hepatic metabolism of vitamin K.
  • Phenobarbital: may enhance vitamin K clearance.
  • Cephalosporins: may interfere with vitamin K synthesis.
  • Direct oral anticoagulants: monitor coagulation status if combined.

Frequently Asked Questions

Konakion Mm Paediatric is used to treat vitamin K deficiency, to prevent bleeding in newborns, and to reverse the effects of anticoagulant therapy such as warfarin in pediatric patients. It provides the essential cofactor needed for normal clotting factor activation.

Phytomenadione serves as a cofactor for the enzyme gamma‑glutamyl carboxylase, which adds a carboxyl group to specific glutamate residues on clotting factors II, VII, IX, and X. This modification enables the factors to bind calcium and become biologically active, restoring normal blood coagulation.

The dose of Konakion Mm Paediatric is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and route of administration. Healthcare professionals follow established guidelines and adjust the amount as needed for each individual case.

Safety data for phytomenadione in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Konakion Mm Paediatric contains phytomenadione, the same active form of vitamin K1 found in most vitamin K preparations. Compared with synthetic analogues, phytomenadione has a well‑established safety profile and is widely used for neonatal prophylaxis and anticoagulant reversal, offering reliable bioavailability across multiple routes.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct light, and avoid exposure to extreme temperatures. Follow any additional handling instructions provided by the manufacturer.

Konakion Mm Paediatric can be given by intramuscular injection, intravenous infusion, or oral administration, depending on the clinical situation and the prescriber's judgment. The route is selected to achieve the desired therapeutic effect while considering patient age and condition.

Serious risks include severe allergic reactions such as anaphylaxis, hemolysis, thrombosis, and paradoxical bleeding despite therapy. Patients should be monitored for signs of hypersensitivity, sudden drop in blood pressure, or unexpected bleeding, and medical attention should be sought immediately if these occur.

Konakion Mm Paediatric should be avoided in individuals with a known hypersensitivity to phytomenadione or any of the product’s excipients. It should also be used with caution in patients with severe liver disease or those receiving medications that may interact significantly, as directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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