Product image of Konakion Mm Paediatric Ampoules (Phytomenadione) supplied by GNH India

Konakion Mm Paediatric Ampoules

Active Ingredient:
Phytomenadione
Origin:
EU

Konakion Mm Paediatric Ampoules (Phytomenadione)

Phytomenadione, the active ingredient in Konakion Mm Paediatric Ampoules, is a vitamin K presented as an injectable solution for intramuscular, intravenous or oral use. It is employed to prevent and treat vitamin K deficiency bleeding, particularly in newborns, and to reverse anticoagulation caused by warfarin.
GNH India supplies Konakion Mm Paediatric Ampoules as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Konakion Mm Paediatric Ampoules provides vitamin K to address disorders of coagulation.

  • Hemorrhagic disease of the newborn: prevents bleeding in neonates at risk of vitamin K deficiency.
  • Vitamin K deficiency bleeding: treats active bleeding in infants and children with low vitamin K levels.
  • Warfarin reversal: restores clotting factor activity in patients requiring rapid anticoagulation reversal.
  • Surgical prophylaxis: reduces peri‑operative bleeding in patients with impaired vitamin K status.

How It Works

  • Phytomenadione acts as a cofactor for the gamma‑carboxylation of glutamic acid residues on clotting factors II, VII, IX and X in the liver. This enzymatic modification enables the synthesis of functional clotting proteins, thereby restoring normal coagulation pathways and preventing hemorrhage.

Side Effects

Adverse reactions may occur following administration of vitamin K injectable solutions.

Common Side Effects

  • Injection site pain or erythema
  • Mild nausea
  • Transient headache
  • Low‑grade fever
  • Diarrhoea
  • Dizziness

Serious or Rare Side Effects

  • Anaphylactic reaction
  • Severe hypotension
  • Hemolysis
  • Jaundice
  • Thrombocytopenia
  • Persistent vomiting

Precautions & Warnings

When using Konakion Mm Paediatric Ampoules, consider the following precautions.

  • Contraindication: Do not use in patients with known hypersensitivity to phytomenadione or formulation excipients.
  • Caution in newborns: Monitor for signs of hyperbilirubinemia after administration.
  • Interaction with anticoagulants: Adjust dosing of concurrent warfarin therapy as needed.
  • Use in pregnancy: Evaluate risk‑benefit ratio; limited data available.
  • Storage: Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Phytomenadione may interact with other medicines affecting coagulation.

Major Interactions (Avoid)

  • Warfarin: can diminish anticoagulant effect, leading to loss of therapeutic control.
  • Broad‑spectrum antibiotics (e.g., cephalosporins): may interfere with vitamin K synthesis, requiring careful monitoring.

Moderate Interactions (Monitor Closely)

  • Rifampin: may increase vitamin K metabolism, reducing efficacy.
  • Phenobarbital: induces hepatic enzymes that accelerate vitamin K clearance.
  • Oral contraceptives: potential additive effect on clotting factors, warranting observation.

Frequently Asked Questions

Konakion Mm Paediatric Ampoules contains phytomenadione, a form of vitamin K, and is used to prevent and treat vitamin K deficiency bleeding in newborns, to reverse the anticoagulant effects of warfarin, and to provide prophylaxis against bleeding in surgical or other clinical situations where clotting support is required.

Phytomenadione serves as a cofactor for the gamma‑carboxylation of specific glutamic acid residues on clotting factors II, VII, IX and X. This biochemical step is essential for producing functional clotting proteins in the liver, thereby restoring normal coagulation and preventing hemorrhage.

The exact dose of Konakion Mm Paediatric Ampoules is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and route of administration. Healthcare professionals should follow local guidelines and individual patient needs when prescribing.

Safety data for phytomenadione during pregnancy and lactation are limited. The drug should only be used when the potential benefit to the mother or infant outweighs any possible risk. Clinicians should assess each case individually and discuss any concerns with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain handling if needed) and any required import documentation.

Konakion Mm Paediatric Ampoules provides phytomenadione in a sterile injectable form, which offers rapid bioavailability compared with oral vitamin K preparations. This can be advantageous in emergency reversal of anticoagulation or in newborn prophylaxis where immediate effect is desired. Other vitamin K products may be oral or have different excipients, influencing stability and administration routes.

The ampoules should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep them in the original packaging until use to maintain sterility and potency. If temperature excursions occur, discard the product according to local regulations.

Konakion Mm Paediatric Ampoules can be given by intramuscular, intravenous, or oral routes, depending on the clinical indication and patient condition. Administration should be performed by qualified healthcare personnel following aseptic technique and appropriate dosing guidelines.

Serious adverse reactions, though rare, include anaphylaxis, severe hypotension, hemolysis, and thrombocytopenia. Immediate medical attention is required if any signs of a severe allergic reaction or unexpected bleeding abnormalities occur after administration.

Patients with a known hypersensitivity to phytomenadione or any component of the formulation should avoid using the product. Additionally, it should be used with caution in individuals with a history of severe allergic reactions, and it is contraindicated in newborns with certain metabolic disorders unless specifically advised by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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