Product image of Konakion (Phytomenadione) supplied by GNH India

Konakion

Active Ingredient:
Phytomenadione
Origin:
EU

Konakion (Phytomenadione)

Phytomenadione, the active ingredient in Konakion, is a Vitamin K presented as a sterile injectable solution for intramuscular, intravenous and oral use. It is employed to prevent and treat vitamin K deficiency bleeding, reverse anticoagulant therapy, and provide neonatal prophylaxis against hemorrhagic disease.
GNH India supplies Konakion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Konakion (phytomenadione) is used to address disorders of vitamin K‑dependent coagulation.

  • Vitamin K deficiency bleeding: restores clotting factor activity to stop or prevent bleeding.
  • Anticoagulant reversal: rapidly counteracts the effects of warfarin or other vitamin K antagonists.
  • Neonatal hemorrhagic disease prophylaxis: provides newborns with the vitamin K needed to avoid early‑life bleeding.

How It Works

  • Phytomenadione acts as a cofactor for the enzyme gamma‑glutamyl carboxylase, enabling gamma‑carboxylation of glutamate residues on clotting factors II, VII, IX and X. This modification produces functional clotting proteins, thereby restoring normal coagulation pathways and correcting vitamin K‑dependent bleeding disorders.

Side Effects

Konakion may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Injection site pain or erythema.
  • Nausea or vomiting.
  • Diarrhea.
  • Transient headache.
  • Mild fever.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reactions.
  • Hemolysis or hematuria.
  • Acute renal failure.
  • Severe hypotension.
  • Thrombosis or embolic events.
  • Persistent elevated bilirubin.

Precautions & Warnings

When using Konakion, clinicians should observe several safety measures.

  • Assess vitamin K status: verify deficiency or need for reversal before administration.
  • Monitor coagulation parameters: check PT/INR after dosing to gauge response.
  • Caution in liver disease: adjust use in patients with impaired hepatic synthesis of clotting factors.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Use with caution in newborns: follow neonatal dosing guidelines.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Konakion can interact with several medications, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Broad‑spectrum antibiotics (e.g., cephalosporins) that impair vitamin K synthesis.
  • High‑dose vitamin E supplements, which may antagonize vitamin K activity.

Moderate Interactions (Monitor Closely)

  • Oral anticoagulants (warfarin, phenprocoumon): may require dose adjustment.
  • Lipid‑lowering agents (statins): potential modest effect on vitamin K metabolism.
  • Herbal products containing coumarins: may enhance anticoagulant effect.
  • Diuretics: monitor electrolyte balance when combined with vitamin K therapy.

Frequently Asked Questions

Konakion is a vitamin K preparation used to prevent and treat bleeding caused by vitamin K deficiency, to reverse the anticoagulant effects of drugs such as warfarin, and to provide prophylaxis against hemorrhagic disease in newborns.

Phytomenadione serves as a cofactor for gamma‑glutamyl carboxylase, enabling the gamma‑carboxylation of clotting factors II, VII, IX and X. This modification creates functional clotting proteins, restoring normal blood coagulation.

The dose of Konakion is determined by the prescribing clinician based on the patient’s age, clinical condition, route of administration and laboratory results. Exact dosing regimens are individualized and should follow local guidelines.

Safety data for phytomenadione in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by the healthcare professional.

To order Konakion, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Konakion (phytomenadione) is a plant‑derived vitamin K1 analogue, whereas many alternatives are synthetic (phytonadione) or derived from animal sources. Clinical efficacy is comparable, but formulation differences may affect stability, storage requirements and specific regulatory approvals.

Konakion should be stored refrigerated at 2‑8 °C, protected from light, and never frozen. The container should remain sealed until use, and any unused portion should be discarded according to local pharmaceutical waste regulations.

Konakion can be given by intramuscular, intravenous or oral routes, depending on the clinical situation. The appropriate route, volume and administration speed are selected by the prescriber and carried out by qualified healthcare personnel.

Serious risks include severe allergic reactions such as anaphylaxis, hemolysis, acute renal failure, and thrombotic events. Immediate medical attention is required if any signs of these reactions appear after administration.

Konakion should be avoided in individuals with known hypersensitivity to phytomenadione or any excipients in the formulation, and it should be used with caution in patients with severe liver disease, renal impairment, or a history of thrombotic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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