Product image of Konakion (Phytomenadione) supplied by GNH India

Konakion

Active Ingredient:
Phytomenadione
Origin:
EU

Konakion (Phytomenadione)

Phytomenadione, the active ingredient in Konakion, is a vitamin K drug presented as a sterile solution for intramuscular, intravenous, and oral use. It restores normal blood clotting in patients with vitamin K deficiency, those receiving anticoagulant therapy, and newborns at risk of hemorrhagic disease.

GNH India supplies Konakion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable logistics and responsive technical support.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Konakion acts on the vitamin K‑dependent coagulation pathway to correct clotting deficiencies.

  • Vitamin K deficiency: restores normal clotting factor synthesis in deficient patients.
  • Anticoagulant‑related bleeding: reverses excessive anticoagulation and reduces bleeding risk.
  • Neonatal hemorrhagic disease prophylaxis: prevents bleeding in newborns at risk.
  • Peri‑operative management: reduces bleeding risk during surgery.
  • Liver disease support: assists clotting factor production in patients with hepatic impairment.

How It Works

  • Phytomenadione provides vitamin K1, which serves as an essential cofactor for the gamma‑carboxylation of clotting factors II, VII, IX and X in the liver. This post‑translational modification enables the factors to bind calcium ions, a critical step for the assembly of the coagulation cascade and the formation of a stable fibrin clot.

Side Effects

Common Side Effects

  • Injection site pain or erythema.
  • Mild nausea or vomiting.
  • Transient flushing or warmth.
  • Headache.
  • Mild diarrhea.
  • Skin rash or itching.

Serious or Rare Side Effects

  • Anaphylactic reaction.
  • Severe bleeding despite therapy.
  • Hemolysis.
  • Thrombosis or embolic events.
  • Severe hypersensitivity reactions.
  • Elevated liver enzymes.

Precautions & Warnings

Konakion should be used with caution in specific clinical situations.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: generally considered compatible, but follow medical advice.
  • Renal impairment: monitor patient closely.
  • Concurrent anticoagulant therapy: adjust dose as needed.
  • Known hypersensitivity: avoid if allergic to phytomenadione.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Konakion may interact with several medications; monitoring is advised.

Major Interactions (Avoid)

  • Warfarin: may reduce anticoagulant effect, requiring dose adjustment.
  • Broad‑spectrum antibiotics: can diminish gut vitamin K synthesis, affecting efficacy.

Moderate Interactions (Monitor Closely)

  • Heparin: additive effect on coagulation, may increase clotting risk.
  • Other vitamin K supplements: may lead to excess vitamin K activity.
  • CYP inducers: may alter phytomenadione metabolism, affecting plasma levels.

Frequently Asked Questions

Konakion is used to treat vitamin K deficiency, reverse bleeding caused by anticoagulant therapy, and provide prophylaxis against hemorrhagic disease in newborns. It helps restore normal clotting factor activity in these clinical situations.

Phytomenadione supplies vitamin K1, which is required for the gamma‑carboxylation of clotting factors II, VII, IX and X. This modification enables the factors to bind calcium and participate effectively in the coagulation cascade, leading to proper blood clot formation.

The dose of Konakion is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and route of administration. Specific dosing regimens are individualized and should follow the prescriber’s instructions.

Use of Konakion during pregnancy or breastfeeding should be discussed with a qualified healthcare provider. While vitamin K is essential for fetal development and may be compatible with breastfeeding, professional guidance is recommended to assess risks and benefits.

To order Konakion, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Konakion contains phytomenadione (vitamin K1), the same active ingredient found in other vitamin K preparations. Compared with synthetic analogues, phytomenadione is the natural form used clinically for rapid correction of deficiency and anticoagulant reversal, offering a well‑established safety profile.

Konakion should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the product. Keep it in the original packaging until use to maintain stability and potency.

Konakion can be given by intramuscular, intravenous or oral routes, depending on the clinical indication and prescriber’s decision. The appropriate route, dosage form and administration technique are selected by the healthcare professional.

Serious risks include anaphylactic reactions, severe bleeding despite treatment, thrombosis or embolic events, and hemolysis. Patients should be monitored for any signs of hypersensitivity or unexpected clotting abnormalities during therapy.

Konakion should be avoided in individuals with known hypersensitivity to phytomenadione or any of its excipients. Caution is also advised for patients with severe liver disease, uncontrolled bleeding disorders, or those receiving conflicting anticoagulant therapies without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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