Product image of Konverge Plus (Olmesartan Medoxomil, Amlodipine, Hydrochlorothiazide) supplied by GNH India

Konverge Plus

Active Ingredient:
Olmesartan Medoxomil, Amlodipine, Hydrochlorothiazide
Origin:
EU

Konverge Plus (Olmesartan Medoxomil, Amlodipine, Hydrochlorothiazide)

Olmesartan medoxomil, amlodipine, and hydrochlorothiazide, the active ingredients in Konverge Plus, are an Angiotensin II receptor blocker, a calcium channel blocker, and a thiazide diuretic presented as an oral tablet for systemic use. The combination is indicated for the management of hypertension in adult patients.

GNH India supplies Konverge Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets. Our distribution network guarantees timely delivery and adherence to stringent quality standards.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Konverge Plus, a combination antihypertensive, acts on the renin‑angiotensin system, vascular smooth muscle tone, and renal sodium handling to lower blood pressure.

  • Hypertension: provides effective reduction of systolic and diastolic blood pressure in adults.
  • Resistant hypertension: offers an additional therapeutic option when monotherapy is insufficient.
  • Multi‑agent therapy: simplifies treatment by combining three agents into a single tablet for patients requiring multiple antihypertensives.

How It Works

  • Olmesartan medoxomil blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. Amlodipine inhibits calcium influx into vascular smooth muscle, causing arterial dilation. Hydrochlorothiazide reduces sodium reabsorption in the distal tubule, increasing diuresis and lowering plasma volume, together producing a synergistic antihypertensive effect.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Peripheral edema
  • Flushing or warmth sensation
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)

Serious or Rare Side Effects

  • Severe hypotension
  • Acute kidney injury
  • Hyperkalemia
  • Angioedema
  • Pancreatitis
  • Hepatic dysfunction

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor blood pressure regularly to assess efficacy.
  • Assess renal function and serum electrolytes, especially potassium.
  • Evaluate hepatic function in patients with known liver disease.
  • Avoid use in patients with known hypersensitivity to any component.
  • Contraindicated in pregnancy due to potential fetal harm.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Konverge Plus may interact with several medicines; careful management is required.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements (risk of hyperkalemia).
  • Lithium (increased lithium toxicity).
  • NSAIDs (may blunt antihypertensive effect).
  • ACE inhibitors (additive risk of hyperkalemia and renal impairment).
  • Cyclosporine or tacrolimus (reduced antihypertensive efficacy).

Moderate Interactions (Monitor Closely)

  • Beta‑blockers (additive hypotensive effect).
  • Other antihypertensives (monitor for excessive blood pressure drop).
  • Antidiabetic agents (possible enhanced hypoglycemia).
  • Antacids containing aluminum or magnesium (may affect absorption).
  • Antifungal azoles (potential increase in amlodipine levels).

Frequently Asked Questions

Konverge Plus is a prescription oral tablet that combines olmesartan medoxomil, amlodipine, and hydrochlorothiazide to treat hypertension. The three agents work together to lower blood pressure in adult patients who need more than one antihypertensive medication.

Olmesartan blocks angiotensin II receptors, reducing vasoconstriction and aldosterone release. Amlodipine relaxes vascular smooth muscle by inhibiting calcium entry, causing arterial dilation. Hydrochlorothiazide increases urinary sodium excretion, decreasing plasma volume. Together they provide a synergistic reduction in blood pressure.

The appropriate dose of Konverge Plus is determined by the prescribing clinician based on the patient’s blood pressure, renal function, and overall treatment plan. Dosage adjustments are made according to clinical response and tolerability.

Konverge Plus is contraindicated in pregnancy because the components may harm the developing fetus. Safety during breastfeeding has not been established, and the medication should be avoided unless the benefits clearly outweigh the risks.

To place an order, submit an enquiry on the Konverge Plus product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any required import documentation.

Compared with single‑agent therapies, Konverge Plus offers the convenience of three proven antihypertensive mechanisms in one tablet, potentially improving adherence. It is an alternative to separate prescriptions of an ARB, a calcium‑channel blocker, and a thiazide diuretic, providing similar efficacy with reduced pill burden.

Konverge Plus should be stored at room temperature, below 25 °C, in the original packaging. Keep the tablet container tightly closed, protect it from moisture and direct light, and store out of reach of children.

Konverge Plus is taken orally, usually once daily, with or without food, as directed by the prescribing physician. Swallow the tablet whole with a full glass of water; do not crush or chew it.

Serious adverse events, although rare, include severe hypotension, acute kidney injury, hyperkalemia, angioedema, pancreatitis, and significant liver dysfunction. Patients should seek immediate medical attention if they experience symptoms such as sudden dizziness, swelling of the face or throat, severe abdominal pain, or jaundice.

Konverge Plus should not be used by individuals with known hypersensitivity to any of its components, pregnant women, patients with severe hepatic impairment, or those with uncontrolled electrolyte disturbances. Clinicians should also avoid prescribing it to patients with severe renal insufficiency without careful monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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