Product image of Kopaq (Iohexol) supplied by GNH India

Kopaq

Active Ingredient:
Iohexol
Origin:
EU

Kopaq (Iohexol)

Iohexol, the active ingredient in Kopaq, is a iodinated contrast media presented as an unknown/unknown for intraarterial, intrathecal, intravenous use. It provides radiodensity for imaging procedures in patients undergoing angiography, CT imaging, myelography, urography and venography.

GNH India supplies Kopaq as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Onko Pharmaceuticals

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Indications & Clinical Uses

Kopaq, an iodinated contrast agent, is used in radiographic imaging procedures to enhance visualization of vascular and organ structures.

  • Angiography: improves visualization of blood vessels during catheter‑based studies.
  • Computed tomography (CT) imaging: enhances contrast between tissues for detailed cross‑sectional images.
  • Myelography: delineates the spinal canal and nerve roots after intrathecal injection.
  • Urography: highlights the urinary tract, facilitating detection of stones or obstruction.
  • Venography: clarifies venous structures for diagnostic assessment.

How It Works

  • Iohexol is a non‑ionic, water‑soluble iodine compound. After intra‑arterial, intravenous or intrathecal administration, its high‑atomic‑number iodine atoms absorb X‑ray photons, increasing the radiodensity of blood, tissues, or cerebrospinal fluid. The resulting contrast between enhanced structures and surrounding anatomy enables detailed imaging without interacting with cellular receptors or metabolic pathways.

Side Effects

Adverse reactions may occur following administration of iodinated contrast media.

Common Side Effects

  • Warm or flushing sensation at the injection site.
  • Nausea or vomiting.
  • Mild headache.
  • Transient hypotension.
  • Metallic taste in the mouth.
  • Mild itching or urticaria.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Acute renal impairment or contrast‑induced nephropathy.
  • Seizures or convulsions.
  • Cardiac arrhythmias or severe hypotension.
  • Pulmonary edema.
  • Life‑threatening cardiovascular collapse.

Precautions & Warnings

When using Kopaq, careful patient assessment and monitoring are essential.

  • Assess renal function: evaluate serum creatinine and eGFR before administration.
  • Screen for iodine allergy: obtain a detailed history of prior contrast reactions.
  • Use the lowest effective volume: adjust dose based on patient size and imaging requirement.
  • Monitor vital signs: observe blood pressure and heart rate during and after injection.
  • Avoid in uncontrolled hyperthyroidism: consider alternative imaging strategies.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Iohexol may interact with other medications that affect renal function or iodine metabolism.

Major Interactions (Avoid)

  • Concurrent iodinated contrast agents: cumulative iodine load can increase toxicity.
  • Metformin in patients with renal impairment: risk of lactic acidosis.
  • Thyroid hormone therapy: may exacerbate hyperthyroid states.

Moderate Interactions (Monitor Closely)

  • NSAIDs: can worsen renal function when combined with contrast.
  • ACE inhibitors or ARBs: may increase risk of contrast‑induced nephropathy.
  • Diuretics: may affect fluid balance and renal clearance.

Frequently Asked Questions

Kopaq is an iodinated contrast medium containing Iohexol. It is administered intravenously, intra‑arterially, or intrathecally to enhance the visibility of blood vessels, organs, and body spaces during angiography, computed tomography (CT), myelography, urography, and venography procedures.

Iohexol works by providing a high concentration of iodine atoms that absorb X‑ray photons. When injected, it increases the radiodensity of the blood, tissues, or cerebrospinal fluid, creating a clear contrast between the enhanced structures and surrounding anatomy, which allows detailed imaging.

The dose of Kopaq is individualized. The prescribing physician determines the volume and concentration based on the specific imaging study, patient weight, renal function, and the route of administration. No standard dose is provided in public literature.

Kopaq is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used when clearly needed, but the prescriber should evaluate the benefit‑risk balance for each pregnant or breastfeeding patient.

To order Kopaq, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Kopaq (Iohexol) is a non‑ionic, low‑osmolality iodinated contrast agent, offering a favorable safety profile compared with older high‑osmolality agents. Compared with other low‑osmolality agents such as iopamidol or iopromide, Iohexol provides similar image quality and is widely used for a broad range of vascular and body imaging studies.

Kopaq should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from direct sunlight, moisture, and extreme temperature fluctuations. Do not freeze the solution, and ensure the container is sealed until use.

Kopaq is administered by a qualified healthcare professional via intravenous, intra‑arterial, or intrathecal injection, depending on the imaging modality. The injection is performed under controlled conditions, with appropriate monitoring of the patient’s vital signs throughout the procedure.

The most serious risks include severe allergic reactions such as anaphylaxis, acute renal impairment (contrast‑induced nephropathy), cardiac arrhythmias, and pulmonary edema. Immediate medical attention is required if any of these reactions occur during or after administration.

Kopaq should be avoided in patients with a known hypersensitivity to iodinated contrast media, severe renal insufficiency (eGFR < 30 mL/min/1.73 m²), uncontrolled hyperthyroidism, or in those who have experienced a prior severe reaction to any iodinated contrast agent.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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