Product image of Kornam (Terazosin) supplied by GNH India

Kornam

Active Ingredient:
Terazosin
Origin:
EU

Kornam (Terazosin)

Terazosin, the active ingredient in Kornam, is a Alpha-1 adrenergic blocker presented as an oral formulation for oral use. It is employed to lower blood pressure in hypertension and to relax smooth muscle in the prostate and bladder neck for treatment of benign prostatic hyperplasia.

GNH India supplies Kornam as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Terazosin acts on the alpha-1 adrenergic receptor pathway to manage vascular and prostatic conditions.

  • Hypertension: lowers systemic blood pressure by causing vasodilation of peripheral arteries.
  • Benign prostatic hyperplasia (BPH): improves urinary flow by relaxing prostate and bladder neck smooth muscle.
  • Prostatic enlargement symptoms: reduces urinary frequency, urgency and nocturia associated with BPH.

How It Works

  • Terazosin selectively antagonizes alpha-1 adrenergic receptors located on vascular smooth muscle and in the prostate and bladder neck. This blockade prevents norepinephrine‑mediated contraction, leading to vasodilation, reduced peripheral resistance, and decreased smooth‑muscle tone in the lower urinary tract, thereby lowering blood pressure and easing urinary obstruction.

Side Effects

Terazosin may cause a range of adverse reactions.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or weakness
  • Nasal congestion
  • Peripheral edema
  • Nausea or abdominal discomfort

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Priapism (prolonged erection)
  • Anaphylactic or severe allergic reaction
  • Liver injury (rare)
  • Cardiac arrhythmia (very rare)

Precautions & Warnings

Terazosin requires careful monitoring and patient education.

  • Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.
  • Orthostatic precautions: advise patients to rise slowly to reduce dizziness.
  • Hepatic impairment: use with caution and consider dose adjustment in patients with liver disease.
  • Concomitant antihypertensives: avoid combining with other potent blood‑pressure‑lowering agents without supervision.
  • Pregnancy and breastfeeding: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Terazosin can interact with several medicines, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase terazosin plasma concentrations.
  • Other alpha‑blockers or strong antihypertensives: additive risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance orthostatic hypotension.

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): increase risk of low blood pressure.
  • Alcohol: can augment dizziness and hypotensive effects.

Frequently Asked Questions

Kornam contains the active ingredient terazosin and is prescribed to manage high blood pressure (hypertension) and to treat symptoms of benign prostatic hyperplasia (BPH), such as urinary difficulty, by relaxing smooth muscle in blood vessels and the prostate.

Terazosin selectively blocks alpha‑1 adrenergic receptors on vascular smooth muscle and in the prostate. This inhibition prevents norepinephrine‑induced contraction, leading to vasodilation that lowers blood pressure and to reduced tone in the prostate and bladder neck, improving urinary flow.

The exact dose of Kornam is determined by the prescribing clinician based on the individual’s condition, response, and tolerance. Physicians typically start with a low dose and titrate upward as needed, following local prescribing guidelines.

Safety of terazosin in pregnancy and lactation has not been established. It should be avoided unless the potential benefit justifies the potential risk to the fetus or infant, and only under direct medical supervision.

To order Kornam, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

For hypertension, terazosin is one of several alpha‑1 blockers, whereas other classes such as ACE inhibitors or calcium channel blockers act via different mechanisms. In BPH, alternatives like tamsulosin also target alpha‑1 receptors but may have different side‑effect profiles. Choice depends on patient comorbidities, tolerability and physician preference.

Store Kornam at ambient temperature, preferably below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain potency and stability.

Kornam is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include severe hypotension leading to fainting, priapism (a prolonged painful erection), and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden dizziness, chest pain, or any signs of an allergic response.

Kornam is contraindicated in patients with known hypersensitivity to terazosin or any component of the formulation, in those with severe liver disease, and in individuals who are already taking other potent alpha‑blockers without medical supervision. Caution is also advised for patients with a history of orthostatic hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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