Kornam (Terazosin)

• Terazosin is used in cardiovascular and urological therapeutic pathways to control blood pressure and relieve prostate‑related urinary obstruction.
• Hypertension: lowers systemic blood pressure by reducing peripheral vascular resistance.
• Benign prostatic hyperplasia: relaxes smooth muscle in the prostate and bladder neck to improve urine flow.
• Lower urinary tract symptoms due to BPH: decreases urinary frequency and urgency associated with prostate enlargement.

• Terazosin selectively blocks alpha‑1 adrenergic receptors on vascular smooth muscle and in the prostate. This blockade prevents norepinephrine‑mediated contraction, leading to vasodilation, reduced peripheral vascular resistance, and relaxation of prostatic and bladder neck smooth muscle, thereby lowering blood pressure and easing urinary obstruction.

Terazosin may cause a range of adverse reactions, from mild to serious.

Common Side Effects

• Dizziness or light‑headedness, especially after the first dose.
• Headache.
• Fatigue or tiredness.
• Nasal congestion.
• Peripheral edema.
• Nausea or mild gastrointestinal upset.

Serious or Rare Side Effects

• Severe hypotension or syncope.
• Priapism (prolonged erection).
• Acute liver injury (rare).
• Allergic reactions such as rash or angioedema.
• Cardiac arrhythmias in susceptible individuals.
• Renal impairment exacerbation.

• Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for adverse events.
• Monitor blood pressure: check for orthostatic changes after the first dose.
• Assess renal and hepatic function: adjust therapy if impairment is present.
• Caution in elderly patients: increased susceptibility to hypotension.
• Avoid abrupt discontinuation: taper to prevent rebound hypertension.
• Use with caution in patients with a history of cardiac disease.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Terazosin can interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

• Concurrent use with other antihypertensives (e.g., ACE inhibitors, ARBs) may cause excessive hypotension.
• PDE5 inhibitors (e.g., sildenafil) increase risk of severe blood‑pressure drops.
• Clonidine withdrawal when combined may precipitate hypertensive crisis.

Moderate Interactions (Monitor Closely)

• Diuretics: may enhance orthostatic hypotension.
• NSAIDs: can blunt antihypertensive effect.
• Beta‑blockers: additive blood‑pressure lowering.
• Lithium: possible increase in serum lithium levels.
• Warfarin: monitor INR as terazosin may affect anticoagulation stability.