Product image of Kostarox (Etoricoxib) supplied by GNH India

Kostarox

Active Ingredient:
Etoricoxib
Origin:
EU

Kostarox (Etoricoxib)

Etoricoxib, the active ingredient in Kostarox, is a COX-2 selective NSAID presented as an oral dosage form for oral use. It is indicated for the management of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain and gout in adult patients.
GNH India supplies Kostarox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

S.C. Sandoz S.R.L.

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Indications & Clinical Uses

Kostarox (etoricoxib) is a COX‑2 selective NSAID used to treat several inflammatory and painful conditions.

  • Osteoarthritis: reduces joint pain and improves mobility.
  • Rheumatoid arthritis: alleviates synovial inflammation and pain.
  • Ankylosing spondylitis: decreases spinal inflammation and stiffness.
  • Acute pain: provides rapid relief of moderate to severe pain.
  • Gout: helps control pain and inflammation during acute gout attacks.

How It Works

  • Etoricoxib selectively inhibits the cyclooxygenase‑2 (COX‑2) enzyme, which is responsible for converting arachidonic acid to prostaglandins that mediate inflammation, pain and fever. By sparing COX‑1, it maintains protective gastric prostaglandins while reducing the production of inflammatory prostaglandins, resulting in decreased swelling and analgesia.

Side Effects

Etoricoxib may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Hypertension: increase in blood pressure readings.
  • Peripheral edema: swelling of the lower limbs.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Cardiovascular events: myocardial infarction or stroke.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic impairment: elevated liver enzymes or hepatitis.

Precautions & Warnings

Before prescribing Kostarox, clinicians should consider several safety aspects.

  • Cardiovascular risk: assess history of heart disease or stroke.
  • Gastrointestinal history: evaluate prior ulcers or bleeding.
  • Renal function: monitor creatinine in patients with kidney disease.
  • Concomitant drugs: review use of anticoagulants, other NSAIDs or corticosteroids.
  • Pregnancy and lactation: avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Etoricoxib can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage potential.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, ARBs, diuretics): possible reduction in blood‑pressure control.
  • Lithium: risk of lithium toxicity due to reduced renal clearance.
  • Methotrexate: potential for increased methotrexate levels.

Frequently Asked Questions

Kostarox contains etoricoxib, a COX‑2 selective NSAID indicated for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain and gout. It helps reduce inflammation and relieve pain associated with these disorders.

Etoricoxib selectively blocks the cyclooxygenase‑2 enzyme, decreasing the synthesis of prostaglandins that cause inflammation, pain and fever. By sparing COX‑1, it preserves protective gastric prostaglandins while providing anti‑inflammatory and analgesic effects.

The appropriate dose of Kostarox is determined by the prescribing healthcare professional based on the patient’s condition, severity, and individual response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of etoricoxib in pregnancy or lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order Kostarox, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Kostarox (etoricoxib) is a COX‑2 selective NSAID, offering similar pain‑relieving and anti‑inflammatory benefits as non‑selective NSAIDs but with a lower risk of gastrointestinal irritation. However, it may carry a higher cardiovascular risk, which should be weighed against other options.

Kostarox should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and store out of reach of children.

Kostarox is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber.

Serious risks include cardiovascular events such as heart attack or stroke, severe skin reactions like Stevens‑Johnson syndrome, and significant liver or kidney impairment. Patients should seek immediate medical attention if they experience chest pain, rash, jaundice or sudden swelling.

Kostarox should be avoided in patients with known hypersensitivity to etoricoxib or other NSAIDs, those with active gastrointestinal bleeding, severe heart failure, recent myocardial infarction, or uncontrolled hypertension. It is also contraindicated in patients with severe liver or kidney disease unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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