Product image of Krenosin (Adenosine) supplied by GNH India

Krenosin

Active Ingredient:
Adenosine
Origin:
EU

Krenosin (Adenosine)

Adenosine, the active ingredient in Krenosin, is a purine nucleoside presented as a solution for injection for intravenous use. It treats paroxysmal supraventricular tachycardia (PSVT) in patients requiring rapid conversion of heart rhythm.

GNH India supplies Krenosin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

  • Adenosine is used in the management of cardiac arrhythmias, particularly supraventricular tachycardia.
  • Paroxysmal supraventricular tachycardia (PSVT): rapid conversion of the arrhythmia to normal sinus rhythm.
  • Supraventricular tachycardia (SVT): termination of episodes when other therapies are unsuitable.
  • Pharmacologic stress testing: used as a vasodilator agent for myocardial perfusion imaging.

How It Works

  • Adenosine activates A1 adenosine receptors on cardiac myocytes, producing a transient block of atrioventricular (AV) nodal conduction and causing brief vasodilation. This rapid, short‑lasting effect interrupts re‑entrant pathways in the AV node, allowing restoration of normal sinus rhythm while also reducing heart rate and blood pressure temporarily.

Side Effects

Adenosine may cause a range of transient adverse reactions following intravenous administration.

Common Side Effects

  • Flushing: warm sensation and reddening of the skin.
  • Chest discomfort: brief pressure or pain in the chest.
  • Shortness of breath: transient dyspnea.
  • Facial flushing: redness of the face.
  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Severe bradycardia: markedly slowed heart rate.
  • Atrioventricular block: prolonged or complete AV conduction delay.
  • Asystole: temporary cessation of cardiac activity.
  • Hypotension: significant drop in blood pressure.
  • Bronchospasm: airway constriction, especially in asthmatic patients.
  • Seizures: rare neurologic events.

Precautions & Warnings

  • Adenosine administration requires careful monitoring and consideration of patient-specific factors.
  • Cardiac monitoring: continuous ECG monitoring is essential during and after injection.
  • Second‑ or third‑degree AV block: avoid use in patients with existing high‑grade AV block.
  • Sick sinus syndrome: contraindicated due to risk of profound bradycardia.
  • Asthma or COPD: use with caution as bronchospasm may occur.
  • Concomitant dipyridamole: avoid because it can potentiate AV nodal block.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Adenosine may interact with several cardiovascular and methylxanthine agents.

Major Interactions (Avoid)

  • Second‑degree or third‑degree AV block: may cause profound bradycardia.
  • Sick sinus syndrome: risk of severe heart rate slowing.
  • Dipyridamole: potentiates AV nodal block.

Moderate Interactions (Monitor Closely)

  • Theophylline: may diminish adenosine's effect.
  • Caffeine: antagonizes adenosine activity, reducing efficacy.

Frequently Asked Questions

Krenosin contains adenosine, which is used primarily to terminate episodes of paroxysmal supraventricular tachycardia (PSVT) and other supraventricular arrhythmias by temporarily blocking AV‑node conduction.

Adenosine activates A1 receptors in the heart, causing a brief interruption of electrical conduction through the atrioventricular node and producing transient vasodilation, which helps restore a normal heart rhythm.

The dose of Krenosin is determined by the prescribing clinician based on the patient’s condition, weight, and response. Specific dosing regimens are not provided here.

Safety data for adenosine in pregnancy and lactation are limited. Use is generally reserved for situations where the benefit outweighs potential risks, and decisions should be made by a qualified healthcare professional.

To order Krenosin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Unlike many antiarrhythmics that act over longer periods, adenosine provides an ultra‑short‑acting effect, making it ideal for rapid conversion of PSVT. Other agents such as beta‑blockers or calcium‑channel blockers have slower onset and longer duration.

Krenosin should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Follow the packaging label for any additional handling instructions.

Krenosin is given as an intravenous bolus injection, typically administered by a trained healthcare professional under continuous cardiac monitoring.

Serious risks include severe bradycardia, high‑grade atrioventricular block, asystole, profound hypotension, and bronchospasm, especially in patients with underlying respiratory disease.

Patients with second‑ or third‑degree AV block, sick sinus syndrome, recent myocardial infarction, or those taking dipyridamole should not receive Krenosin unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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