Kreon 25 000 (Pancreatin)

• Kreon 25 000 provides pancreatic enzyme replacement for disorders that cause exocrine pancreatic insufficiency.
• Cystic fibrosis: improves digestion and nutrient absorption by supplying missing lipase, amylase and protease.
• Chronic pancreatitis: reduces steatorrhea and abdominal discomfort by supplementing pancreatic enzymes.
• Pancreatic cancer: aids in maintaining caloric intake when tumor impairs pancreatic function.
• Pancreatic resection: compensates for loss of pancreatic tissue after surgery, supporting normal digestion.

• Pancreatin contains a mixture of lipase, amylase and protease that are released in the small intestine after the enteric coating dissolves. These enzymes hydrolyze dietary fats, carbohydrates and proteins, thereby compensating for the reduced endogenous pancreatic secretion seen in exocrine pancreatic insufficiency and facilitating nutrient absorption.

Kreon 25 000 may cause gastrointestinal and hypersensitivity reactions.

Common Side Effects

• Abdominal discomfort or cramping
• Flatulence or bloating
• Oily, foul‑smelling stools
• Nausea or vomiting
• Diarrhea
• Mild abdominal pain

Serious or Rare Side Effects

• Anaphylactic or severe allergic reaction
• Acute pancreatitis exacerbation
• Severe abdominal pain with vomiting
• Intestinal obstruction or blockage
• Stevens‑Johnson syndrome or severe skin rash
• Hypersensitivity with respiratory distress

• Before prescribing Kreon 25 000, consider the following safety measures.
• Dose adjustment: required in patients with significant renal or hepatic impairment.
• Monitoring: regularly assess nutritional status, weight gain and stool characteristics.
• Allergy: avoid in individuals with known hypersensitivity to porcine proteins.
• Pregnancy: safety not established; use only if potential benefit justifies the risk.
• Drug interactions: antacids or acid‑suppressing agents may reduce enzyme activity.
• Store at ambient temperature: keep in the original container, protect from moisture and heat.

Kreon 25 000 can interact with other medications that affect gastric acidity or enzyme activity.

Major Interactions (Avoid)

• Proton pump inhibitors: may reduce activation of enteric‑coated enzymes.
• Antacids containing aluminum or magnesium: can bind enzymes and diminish efficacy.

Moderate Interactions (Monitor Closely)

• Oral corticosteroids: may increase risk of gastrointestinal irritation.
• Lipase inhibitors (e.g., orlistat): may compete for substrate and alter digestion.
• Broad‑spectrum antibiotics: changes in gut flora could affect enzyme function.