Product image of Kreon (Pancreas Powder) supplied by GNH India

Kreon

Active Ingredient:
Pancreas Powder
Origin:
EU

Kreon (Pancreas Powder)

Pancreas Powder, the active ingredient in Kreon, is a pancreatic enzyme replacement presented as a delayed-release capsule for oral use. It treats exocrine pancreatic insufficiency in conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, and post‑surgical pancreatic insufficiency.

GNH India supplies Kreon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Austria Gmbh

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Indications & Clinical Uses

Kreon is used to replace deficient pancreatic enzymes in disorders that impair digestion.

  • Exocrine pancreatic insufficiency due to cystic fibrosis: improves digestion of fats, proteins, and carbohydrates.
  • Chronic pancreatitis: aids nutrient absorption and reduces steatorrhea.
  • Pancreatic cancer: supports digestive function when pancreatic tissue is compromised.
  • Post‑surgical pancreatic insufficiency: provides necessary enzymes after pancreatic resection.

How It Works

  • Kreon supplies exogenous pancreatic enzymes—lipase, amylase, and protease—in a delayed‑release formulation that protects them from gastric acid. The capsule dissolves in the duodenum, where the enzymes become active and assist the breakdown of dietary fats, carbohydrates, and proteins, thereby enhancing nutrient absorption in patients with insufficient endogenous pancreatic secretion.

Side Effects

Kreon may cause adverse reactions, most of which are mild and related to gastrointestinal tolerance.

Common Side Effects

  • Abdominal discomfort: mild pain or cramping.
  • Diarrhea: loose stools.
  • Nausea: feeling of sickness.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling.
  • Respiratory distress: wheezing or shortness of breath.
  • Severe abdominal pain: may indicate pancreatitis.

Precautions & Warnings

When using Kreon, consider the following precautions.

  • Dose adjustment: titrate based on clinical response and stool fat content.
  • Monitoring: assess nutritional status and weight regularly.
  • Concomitant meds: avoid antacids that may reduce enzyme activity.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Kreon can interact with several medicines; awareness helps maintain efficacy.

Major Interactions (Avoid)

  • Proton pump inhibitors: may reduce enzyme activation in the intestine.
  • Antacids containing aluminum or magnesium: can bind enzymes and lower efficacy.

Moderate Interactions (Monitor Closely)

  • Lipid‑lowering agents (e.g., orlistat): may interfere with fat digestion.
  • Antibiotics affecting gut flora: could alter enzyme activity.
  • High‑dose vitamin supplements: may affect absorption.

Frequently Asked Questions

Kreon is prescribed for patients with exocrine pancreatic insufficiency caused by conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, or after pancreatic surgery. It provides the digestive enzymes that the pancreas is unable to produce, helping to break down fats, proteins, and carbohydrates for better nutrient absorption.

Pancreas Powder contains lipase, amylase, and protease enzymes that are protected by a delayed‑release coating. The capsule dissolves in the duodenum, releasing the enzymes where they can act on ingested food, facilitating the breakdown and absorption of nutrients that would otherwise be poorly digested.

The dosage of Kreon is individualized and determined by the prescribing healthcare professional. The prescriber will consider the patient’s condition, severity of enzyme deficiency, and response to therapy when setting the appropriate number of capsules per meal or snack.

Safety data for Kreon in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Kreon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kreon, like other porcine‑derived enzyme preparations (e.g., Creon, Pancreaze), delivers lipase, amylase, and protease in a delayed‑release form. Differences may lie in enzyme potency per capsule, specific dosing recommendations, and excipient composition. Selection is typically based on physician preference, patient tolerance, and cost considerations.

Kreon capsules should be stored below 25 °C, in their original packaging, and protected from moisture. Keep the container tightly closed and avoid exposure to high humidity or direct sunlight to maintain enzyme stability.

Kreon is taken orally, usually with each main meal and snack that contains fat. The capsules should be swallowed whole with water and not crushed or chewed, as the coating protects the enzymes until they reach the small intestine.

Serious risks include allergic reactions such as rash, swelling, or anaphylaxis, respiratory distress like wheezing, and severe abdominal pain that could signal pancreatitis. Patients should seek immediate medical attention if any of these symptoms occur.

Kreon should not be used by individuals with a known hypersensitivity to porcine proteins or any of the capsule’s excipients. Patients with severe gastrointestinal disorders that affect absorption may also require alternative management under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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