Product image of Kreon (Pancreas Powder) supplied by GNH India

Kreon

Active Ingredient:
Pancreas Powder
Origin:
EU

Kreon (Pancreas Powder)

Pancreas Powder, the active ingredient in Kreon, is a pancreatic enzyme replacement therapy presented as a powder for oral use. It provides lipase, amylase and protease to aid digestion in patients with exocrine pancreatic insufficiency, cystic fibrosis, and chronic pancreatitis, and improves nutrient absorption.

GNH India supplies Kreon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. Our distribution network ensures timely delivery across Europe, Asia, Africa and the Americas.

Manufacturer / TM Owner

Viatris Hrvatska D.O.O.

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Indications & Clinical Uses

Kreon, a pancreatic enzyme replacement therapy, acts on the digestive process in conditions characterized by exocrine pancreatic insufficiency.

  • Exocrine pancreatic insufficiency: improves digestion of fats, proteins and carbohydrates, reducing malabsorption symptoms.
  • Cystic fibrosis: provides essential enzymes to aid nutrient absorption in patients with pancreatic dysfunction.
  • Chronic pancreatitis: supplements deficient pancreatic enzymes to support digestive function.

How It Works

  • Kreon contains a mixture of lipase, amylase and protease derived from porcine pancreas. When taken with meals, the enzymes are released in the duodenum where they hydrolyze dietary triglycerides, starches and proteins, compensating for the patient’s deficient endogenous pancreatic secretion and facilitating normal nutrient absorption.

Side Effects

Kreon may be associated with a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Abdominal discomfort: mild pain or cramping after dosing.
  • Flatulence: increased intestinal gas.
  • Diarrhea: loose stools.
  • Nausea: feeling of sickness.

Serious or Rare Side Effects

  • Pancreatitis: inflammation of the pancreas requiring medical attention.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Kreon should be used with caution and under medical supervision.

  • Dose titration: adjust enzyme dose based on clinical response and dietary fat intake.
  • Medical supervision: use under physician guidance, especially in children.
  • Monitoring: assess nutritional status and stool characteristics regularly.
  • Drug interactions: avoid concomitant use with antacids that may reduce enzyme activity.
  • Storage: Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Kreon may interact with certain medications; awareness of interaction severity is important.

Major Interactions (Avoid)

  • Proton pump inhibitors: may reduce enzyme activation; consider timing separation.
  • Antacids containing aluminum or magnesium: can bind enzymes and diminish efficacy.

Moderate Interactions (Monitor Closely)

  • Orlistat: may interfere with enzyme activity; monitor fat digestion.
  • Clarithromycin: potential alteration of gut flora affecting enzyme function.
  • Warfarin: rare reports of altered INR; monitor coagulation parameters.

Frequently Asked Questions

Kreon is prescribed for patients who have exocrine pancreatic insufficiency, cystic fibrosis or chronic pancreatitis. In these conditions the pancreas does not produce enough digestive enzymes, and Kreon supplies lipase, amylase and protease to help break down fats, carbohydrates and proteins, improving nutrient absorption and reducing malabsorption symptoms.

Pancreas Powder contains a blend of pancreatic enzymes that mimic the natural enzymes produced by the pancreas. When taken with meals, the enzymes act in the small intestine to hydrolyze dietary fats, starches and proteins, compensating for the patient’s deficient enzyme production and facilitating normal digestion and absorption.

The appropriate dose of Kreon is individualized and determined by the prescribing healthcare professional. Dosage depends on factors such as the patient’s age, weight, severity of enzyme deficiency, and the fat content of the diet. Patients should follow the specific instructions provided by their physician or pharmacist.

Limited clinical data are available on the use of Kreon during pregnancy or lactation. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the therapy with their healthcare provider.

To request Kreon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the enquiry, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details and any required import documentation.

Kreon provides a comprehensive mix of lipase, amylase and protease similar to other prescription pancreatic enzyme preparations. Its formulation is designed for oral administration with meals and offers consistent enzyme activity. Compared with over‑the‑counter supplements, Kreon is a regulated, prescription‑only product with standardized potency and quality controls required by EU regulations.

Kreon should be stored at ambient temperature below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date. No special refrigeration is required for this oral powder formulation.

Kreon is taken orally with each main meal and snack that contains fat. The powder is usually mixed with a small amount of water or soft food as directed by the prescribing physician. Patients should not crush or chew the capsules if they are in capsule form, and should follow the timing recommendations to maximize enzyme activity.

The most serious adverse events linked to Kreon are pancreatitis and severe allergic reactions, including anaphylaxis. Patients should seek immediate medical attention if they experience intense abdominal pain, persistent vomiting, rash, swelling, difficulty breathing, or any signs of a systemic allergic response while using the product.

Kreon is contraindicated in individuals with known hypersensitivity to pork-derived proteins or any of the enzyme components. Patients with a history of severe allergic reactions to pancreatic enzyme preparations should avoid its use. Additionally, it should not be used without medical supervision in patients who have not been diagnosed with pancreatic enzyme deficiency.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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