Product image of Kreon (Pancreas Powder) supplied by GNH India

Kreon

Active Ingredient:
Pancreas Powder
Origin:
EU

Kreon (Pancreas Powder)

Pancreatin, the active ingredient in Kreon, is a pancreatic enzyme replacement presented as an enteric‑coated capsule for oral use. It treats exocrine pancreatic insufficiency in conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, and after pancreatic resection.

GNH India supplies Kreon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Kreon, a pancreatic enzyme replacement, is used to manage exocrine pancreatic insufficiency across several gastrointestinal conditions.

  • Cystic fibrosis: improves digestion and nutrient absorption by providing essential pancreatic enzymes.
  • Chronic pancreatitis: alleviates malabsorption symptoms and supports nutritional status.
  • Pancreatic cancer: assists in digestion when tumor or treatment impairs pancreatic function.
  • Post‑pancreatic resection: compensates for loss of endogenous enzyme production after surgery.

How It Works

  • Pancreatin contains lipase, amylase, and protease enzymes that are released in the small intestine after the enteric coating dissolves. These enzymes hydrolyze dietary fats, carbohydrates, and proteins, thereby compensating for deficient pancreatic secretion and facilitating normal nutrient digestion and absorption.

Side Effects

Kreon may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal discomfort or pain
  • Flatulence or bloating
  • Diarrhea or loose stools
  • Nausea or vomiting
  • Constipation
  • Oily or fatty stools (steatorrhea)

Serious or Rare Side Effects

  • Severe allergic reactions including anaphylaxis
  • Pancreatitis or worsening abdominal pain
  • Intestinal obstruction or blockage
  • Fecal incontinence
  • Persistent vomiting or dehydration

Precautions & Warnings

When using Kreon, consider the following safety measures.

  • Dose Adjustment: follow the prescriber's individualized dosing plan.
  • Nutritional Monitoring: regularly assess weight, vitamin levels, and stool characteristics.
  • Allergy Screening: avoid use in patients with known hypersensitivity to porcine proteins.
  • Meal Timing: take capsules with meals and snacks for optimal enzyme activity.
  • Concomitant Medications: evaluate potential interactions with acid‑reducing agents.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Kreon can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Proton pump inhibitors or H2 blockers: may reduce enzyme activation by raising gastric pH.
  • Cholestyramine or other bile‑acid sequestrants: can bind pancreatic enzymes and diminish their effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: altered vitamin K absorption may affect anticoagulation control.
  • Oral contraceptives: fat malabsorption could modify hormone levels.
  • Tetracycline antibiotics: may chelate with enzymes and reduce their activity.

Frequently Asked Questions

Kreon is prescribed to patients with exocrine pancreatic insufficiency, helping them digest fats, proteins, and carbohydrates when the pancreas cannot produce sufficient enzymes. It is indicated for conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, and after surgical removal of part of the pancreas.

Pancreatin provides a mixture of lipase, amylase, and protease enzymes that mimic natural pancreatic secretions. After the enteric coating dissolves in the small intestine, these enzymes break down dietary fats, starches, and proteins, improving nutrient absorption and reducing malabsorption symptoms.

The appropriate dose of Kreon is individualized by the prescribing healthcare professional based on the patient’s age, weight, severity of enzyme deficiency, and dietary fat content. Patients should follow the prescriber’s instructions and adjust dosing only under medical guidance.

The safety of Kreon in pregnancy or lactation has not been definitively established. Healthcare providers weigh potential benefits against unknown risks before prescribing it to pregnant or nursing women. Patients should discuss any concerns with their physician.

To request Kreon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required temperature control), and import documentation.

Kreon contains porcine‑derived pancreatin similar to other branded enzyme preparations such as Creon or Pancrelipase. Differences may lie in enzyme potency per capsule, coating technology, and regulatory status. Clinicians choose a product based on individual patient response, dosing convenience, and local availability.

Kreon should be stored at room temperature, below 25 °C, in its original blister pack to protect the enteric coating from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Kreon is taken orally, swallowed whole with a full glass of water during or immediately after meals and snacks. The enteric coating ensures the enzymes are released in the small intestine where they can act on ingested food.

Serious adverse events include severe allergic reactions (anaphylaxis), pancreatitis, intestinal obstruction, and persistent vomiting leading to dehydration. Patients should seek immediate medical attention if they experience intense abdominal pain, swelling, difficulty breathing, or any signs of an allergic response.

Kreon is contraindicated in individuals with a known hypersensitivity to porcine proteins or any component of the formulation. It should also be used with caution in patients with severe gastrointestinal disorders that could impair capsule dissolution or increase the risk of obstruction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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