Product image of Kreon (Pancreas Powder) supplied by GNH India

Kreon

Active Ingredient:
Pancreas Powder
Origin:
EU

Kreon (Pancreas Powder)

Pancreatin, the active ingredient in Kreon, is a pancreatic enzyme replacement presented as enteric‑coated capsules for oral use. It provides exogenous lipase, amylase and protease to aid digestion in patients with exocrine pancreatic insufficiency, cystic fibrosis or chronic pancreatitis.

GNH India supplies Kreon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

  • Kreon is a pancreatic enzyme replacement that addresses digestive insufficiency in several disease groups.
  • Exocrine pancreatic insufficiency: improves digestion of fats, proteins and carbohydrates, reducing steatorrhea and malabsorption.
  • Cystic fibrosis: supplements deficient pancreatic enzymes, supporting nutritional status and growth.
  • Chronic pancreatitis: provides necessary digestive enzymes to alleviate maldigestion and related symptoms.

How It Works

  • Pancreatin contains lipase, amylase and protease derived from porcine pancreas. After the enteric‑coated capsule dissolves in the duodenum, these enzymes hydrolyze dietary fats, carbohydrates and proteins, facilitating their absorption and reducing the burden of undigested nutrients in the gastrointestinal tract.

Side Effects

Kreon may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal discomfort or pain
  • Flatulence or bloating
  • Diarrhea or loose stools
  • Nausea or mild vomiting
  • Constipation
  • Oily or fatty stools

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching or anaphylaxis
  • Intestinal obstruction or blockage
  • Severe abdominal pain
  • Fecal incontinence
  • Pancreatitis exacerbation
  • Hypersensitivity leading to respiratory distress

Precautions & Warnings

  • Before initiating Kreon, consider the following precautions.
  • Dose titration: adjust based on clinical response and stool fat content.
  • Medical supervision: use under physician guidance, especially in patients with diabetes.
  • Allergy assessment: avoid if known hypersensitivity to porcine‑derived products.
  • Concurrent acid suppression: proton pump inhibitors may reduce efficacy; monitor.
  • Pregnancy and lactation: safety not established; weigh benefits versus potential risks.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Kreon can interact with other medications that affect gastric pH or gastrointestinal function.

Major Interactions (Avoid)

  • Proton pump inhibitors: may reduce enzyme activation in the duodenum.
  • Antacids containing aluminum or magnesium: can bind enzymes and lower effectiveness.
  • Orlistat: may interfere with fat digestion and enzyme activity.

Moderate Interactions (Monitor Closely)

  • Antibiotics altering gut flora: may affect enzyme activity.
  • Diabetes medications: enhanced carbohydrate digestion may impact glucose control.
  • Corticosteroids: may increase risk of gastrointestinal side effects.

Frequently Asked Questions

Kreon is prescribed to patients who lack sufficient pancreatic enzymes. It helps digest fats, proteins and carbohydrates in conditions such as exocrine pancreatic insufficiency, cystic fibrosis and chronic pancreatitis, thereby improving nutrient absorption and reducing symptoms like steatorrhea.

Pancreatin supplies the three major digestive enzymes—lipase, amylase and protease. After the enteric‑coated capsule releases its contents in the duodenum, these enzymes break down dietary fats, carbohydrates and proteins, facilitating their absorption and reducing the amount of undigested material that reaches the lower intestine.

The appropriate dose of Kreon is individualized. A qualified prescriber determines the number of capsules based on the patient’s clinical response, dietary fat intake and stool fat measurements. Dosage may be adjusted over time to achieve optimal digestive outcomes.

Safety data for Kreon in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Physicians should evaluate each case carefully and discuss uncertainties with the patient.

To request Kreon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any necessary import documentation.

Kreon, like other porcine‑derived enzyme preparations (e.g., Creon, Pancreaze), contains lipase, amylase and protease in an enteric‑coated form. Differences lie mainly in enzyme potency per capsule and dosing schedules. Clinicians may choose a product based on individual patient response, capsule size, and cost considerations.

Kreon capsules should be stored at temperatures below 25 °C, in their original container, and protected from moisture and direct sunlight. Do not expose the product to excessive heat or humidity, as this may compromise the enteric coating and enzyme activity.

Kreon is taken orally, whole, with each main meal and snack that contains fat. The capsule should be swallowed with water and not crushed or chewed, ensuring the enteric coating remains intact until it reaches the duodenum where the enzymes are released.

Serious adverse events, although rare, include allergic reactions such as rash, itching, swelling or anaphylaxis, and intestinal obstruction. Patients should seek immediate medical attention if they experience severe abdominal pain, difficulty breathing, or signs of a hypersensitivity reaction.

Kreon is contraindicated in individuals with a known hypersensitivity to porcine pancreatic tissue or any of its excipients. Patients with severe gastrointestinal obstruction or those who have had recent major abdominal surgery should avoid use until evaluated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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