Product image of Kreon (Pancreatin) supplied by GNH India

Kreon

Active Ingredient:
Pancreatin
Origin:
EU

Kreon (Pancreatin)

Pancreatin, the active ingredient in Kreon, is a digestive enzyme presented as an oral capsule for oral use. It provides exogenous pancreatic enzymes to aid digestion in patients with exocrine pancreatic insufficiency caused by cystic fibrosis, chronic pancreatitis, pancreatic cancer, or post‑surgical pancreatic insufficiency. The therapy helps normalize nutrient absorption and reduce steatorrhea.

GNH India supplies Kreon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. Our distribution network ensures reliable access to quality medicines across multiple regions.

Manufacturer / TM Owner

Viatris Healthcare Lda.

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Indications & Clinical Uses

Kreon is used to replace deficient pancreatic enzymes in conditions characterized by exocrine pancreatic insufficiency.

  • Cystic fibrosis: improves digestion of fats, proteins and carbohydrates, reducing malabsorption symptoms.
  • Chronic pancreatitis: aids nutrient absorption and lessens steatorrhea.
  • Pancreatic cancer: supports digestion when tumor or treatment impairs pancreatic function.
  • Post‑surgical pancreatic insufficiency: compensates for loss of enzyme production after pancreatic resection.

How It Works

  • Pancreatin contains lipase, amylase and protease that are released in the duodenum where they hydrolyze triglycerides, starches and proteins respectively. By supplying these exogenous enzymes, the preparation compensates for the reduced endogenous pancreatic secretion, facilitating the breakdown and absorption of dietary fats, carbohydrates and amino acids.

Side Effects

Kreon may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Abdominal pain or discomfort.
  • Flatulence or bloating.
  • Diarrhea or loose stools.
  • Nausea or mild vomiting.
  • Constipation.
  • Oily or fatty stools.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, rash, swelling).
  • Acute pancreatitis exacerbation.
  • Intestinal obstruction.
  • Persistent severe abdominal pain.
  • Fecal incontinence.
  • Unexplained weight loss.

Precautions & Warnings

Before initiating Kreon, consider the following precautions.

  • Dose titration: adjust based on clinical response and stool fat content.
  • Monitoring: regularly assess nutritional status, weight and vitamin levels.
  • Drug interactions: avoid concomitant use of antacids that may inactivate enzymes.
  • Medical conditions: use caution in patients with known hypersensitivity to porcine proteins.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Kreon can interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Proton pump inhibitors: may reduce enzyme activity.
  • Antacids containing aluminum or magnesium: can inactivate pancreatic enzymes.
  • Orlistat: may interfere with enzyme efficacy.

Moderate Interactions (Monitor Closely)

  • Tetracycline antibiotics: may affect absorption of the enzyme preparation.
  • Fat‑soluble vitamins (A, D, E, K): supplementation may be required and should be monitored.

Frequently Asked Questions

Kreon is a pancreatic enzyme replacement therapy indicated for exocrine pancreatic insufficiency caused by conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, and post‑surgical pancreatic loss. It supplies lipase, amylase and protease to improve digestion of fats, carbohydrates and proteins, helping to reduce malabsorption and related symptoms.

Pancreatin in Kreon provides the three major digestive enzymes—lipase, amylase and protease. When taken with meals, these enzymes act in the small intestine to hydrolyze triglycerides, starches and proteins, respectively, compensating for the patient’s deficient pancreatic secretion and facilitating nutrient absorption.

The appropriate dose of Kreon is individualized and set by the prescribing healthcare professional. Dosage is typically adjusted according to the patient’s weight, severity of enzyme deficiency, dietary fat content and clinical response, with regular monitoring to achieve optimal nutritional outcomes.

Safety data for Kreon in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing it to pregnant or nursing individuals.

To request Kreon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kreon contains a standardized blend of lipase, amylase and protease similar to other pancreatic enzyme brands such as Creon or Pancrease. Differences may lie in enzyme potency per capsule, formulation excipients, and regulatory approvals. Clinicians choose a product based on patient tolerance, dosing convenience and local availability.

Kreon should be stored at ambient temperature, below 25 °C, in its original container to protect it from moisture and excessive heat. Keep the capsules tightly sealed and out of reach of children. Do not store in humid environments such as bathrooms.

Kreon is taken orally, usually with each main meal and snack that contains fat. The capsules should be swallowed whole with water; they are not intended to be opened, crushed or mixed with food unless specifically instructed by a healthcare professional.

Serious adverse events, although rare, include severe allergic reactions (anaphylaxis, rash, swelling), acute pancreatitis exacerbation, intestinal obstruction and persistent severe abdominal pain. Patients should seek immediate medical attention if they experience any of these symptoms.

Kreon is contraindicated in individuals with a known hypersensitivity to porcine-derived proteins or any component of the formulation. Patients with severe, uncontrolled gastrointestinal disorders or those who have experienced a serious allergic reaction to pancreatic enzyme products should avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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