Product image of Kriolen (Ambroxol Hydrochloride) supplied by GNH India

Kriolen

Active Ingredient:
Ambroxol Hydrochloride
Origin:
EU

Kriolen (Ambroxol Hydrochloride)

Ambroxol Hydrochloride, the active ingredient in Kriolen, is a mucolytic presented as an oral formulation for oral use. It is used to facilitate the clearance of thick mucus in respiratory conditions such as acute and chronic bronchitis, COPD, and upper respiratory tract infections.

GNH India supplies Kriolen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to GMP standards and provides regulatory‑compliant packaging for global distribution. It ensures product integrity through stringent quality control and traceability throughout the supply chain.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Ambroxol Hydrochloride is a mucolytic that acts on respiratory mucus production and clearance.

  • Acute and chronic bronchitis: helps loosen and clear thick bronchial secretions, improving cough efficiency.
  • Cough with thick or viscous sputum: reduces sputum viscosity, facilitating expectoration.
  • Chronic obstructive pulmonary disease (COPD): aids mucus clearance, supporting airway patency.
  • Upper respiratory tract infections: assists in clearing mucus, relieving congestion and cough.

How It Works

  • Ambroxol Hydrochloride breaks down mucopolysaccharide fibers in mucus, decreasing its viscosity. It stimulates surfactant production by type II pneumocytes, enhancing mucociliary clearance. The compound also exhibits local anti‑inflammatory and anesthetic effects on the respiratory epithelium, further supporting the removal of secretions and reducing cough irritation.

Side Effects

Common Side Effects

  • Altered taste sensation: a transient bitter or salty taste.
  • Nausea: mild gastrointestinal discomfort.
  • Abdominal discomfort: occasional stomach cramps.
  • Diarrhea: loose stools in some patients.
  • Headache: mild to moderate intensity.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Stevens‑Johnson syndrome: rare severe skin eruption.
  • Hepatic enzyme elevation: potential liver function alteration.
  • Eosinophilia or neutropenia: abnormal blood cell counts.
  • Severe bronchospasm: paradoxical airway constriction.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor for hypersensitivity: discontinue if allergic reactions occur.
  • Caution in asthma: may provoke bronchospasm in susceptible individuals.
  • Avoid in known hypersensitivity to ambroxol or related compounds.
  • Use during pregnancy and lactation only if clearly needed after risk‑benefit assessment.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ambroxol Hydrochloride may interact with other medicines as follows:

Major Interactions (Avoid)

  • Concurrent use with codeine‑containing antitussives: may diminish mucolytic effectiveness.
  • Combination with other mucolytics (e.g., N‑acetylcysteine): risk of excessive mucus thinning.

Moderate Interactions (Monitor Closely)

  • Bronchodilators (e.g., salbutamol): monitor for additive respiratory effects.
  • Anticoagulants (e.g., warfarin): observe for any change in bleeding tendency.
  • CYP450 inhibitors: theoretical increase in ambroxol plasma levels; monitor clinical response.

Frequently Asked Questions

Kriolen contains Ambroxol Hydrochloride, a mucolytic indicated for conditions that involve thick or viscous respiratory secretions. It is commonly prescribed for acute and chronic bronchitis, COPD, cough with thick sputum, and upper respiratory tract infections to help clear mucus and improve breathing.

Ambroxol Hydrochloride reduces mucus viscosity by breaking down mucopolysaccharide fibers and stimulates surfactant production in the lungs. This dual action enhances mucociliary clearance, eases expectoration, and also provides local anti‑inflammatory and anesthetic effects that lessen cough irritation.

The appropriate dose of Kriolen is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of the condition, and renal function. Patients should follow the exact regimen provided by their prescriber and not adjust the dose on their own.

Safety data for Ambroxol Hydrochloride in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant. The prescriber will evaluate the individual situation before recommending therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Kriolen. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kriolen’s active ingredient, Ambroxol Hydrochloride, offers both mucolytic and surfactant‑stimulating properties, which can provide faster mucus clearance compared with some older agents that act solely on viscosity. Its additional local anti‑inflammatory effect may also reduce cough irritation, making it a preferred option in many respiratory protocols.

Kriolen should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

Kriolen is taken orally, usually in tablet or liquid form, as directed by the prescriber. It should be swallowed with a glass of water, and dosing times may be spaced to align with meals or other medications as advised by the healthcare professional.

Serious adverse reactions, though rare, include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms like rash, swelling, difficulty breathing, or jaundice.

Kriolen is contraindicated in individuals with known hypersensitivity to Ambroxol Hydrochloride or any of its excipients. Caution is also advised for patients with severe renal impairment, uncontrolled asthma, or those who have experienced severe allergic reactions to mucolytic agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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