Kruidvat Flurbiprofen Mint Healthypharm (Flurbiprofen)

Flurbiprofen acts locally on inflammatory pathways in the oral cavity and pharynx, providing analgesic and anti‑inflammatory effects.

• Sore throat: reduces pain and inflammation of the pharyngeal mucosa.
• Oral mucosal inflammation: alleviates redness and swelling of oral lesions.
• Mild to moderate pain: provides short‑term relief of discomfort in the oropharyngeal region.

• Flurbiprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis limits inflammation, pain signalling, and fever generation at the site of application.

Flurbiprofen may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Taste alteration: temporary minty or bitter sensation.
• Local irritation: mild burning or tingling in the mouth.
• Dry mouth: reduced salivation during use.
• Nausea: occasional upset stomach.
• Headache: mild tension‑type headache.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Gastrointestinal ulceration: rare bleeding or ulcer formation in the stomach or intestine.
• Renal impairment: reduced kidney function in susceptible individuals.
• Hepatic dysfunction: elevated liver enzymes or jaundice.
• Severe hypersensitivity: anaphylaxis requiring immediate medical attention.

Before using Flurbiprofen, consider the following safety measures.

• Allergy assessment: avoid if known hypersensitivity to flurbiprofen or other NSAIDs.
• Gastro‑intestinal risk: use with caution in patients with a history of ulcers or bleeding.
• Renal function: monitor kidney health in patients with pre‑existing renal disease.
• Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
• Concomitant medications: review all current drugs for potential interactions.
• Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture and direct sunlight.

Flurbiprofen can affect the activity of several other medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
• Corticosteroids: amplified risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect.
• Diuretics: may diminish diuretic efficacy and affect renal function.
• Lithium: potential increase in lithium serum levels.
• Methotrexate: reduced clearance leading to toxicity.