Product image of Kruklar (Clarithromycin) supplied by GNH India

Kruklar

Active Ingredient:
Clarithromycin
Origin:
EU

Kruklar (Clarithromycin)

Clarithromycin, the active ingredient in Kruklar, is a macrolide antibiotic presented as an oral tablet for systemic use. It treats bacterial infections such as community‑acquired pneumonia, sinusitis, skin infections, Helicobacter pylori infection and streptococcal pharyngitis in adults and children as prescribed.
GNH India supplies Kruklar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

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Indications & Clinical Uses

Clarithromycin is employed to treat bacterial infections across several organ systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Skin and soft tissue infections: eliminates pathogenic bacteria and promotes wound healing.
  • Helicobacter pylori infection: part of combination therapy to achieve bacterial eradication.
  • Streptococcal pharyngitis: resolves throat infection and prevents complications.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting translocation of the peptidyl‑tRNA. This blocks protein synthesis, leading to a bacteriostatic effect against susceptible organisms and, at higher concentrations, a bactericidal effect.

Side Effects

Clarithromycin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered or metallic taste.
  • Headache: transient headache episodes.
  • Vomiting: occasional emesis.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • QT prolongation: cardiac rhythm disturbance that can lead to arrhythmia.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • Stevens‑Johnson syndrome: life‑threatening skin reaction.
  • Cardiac arrhythmias: irregular heartbeats beyond QT issues.

Precautions & Warnings

Clarithromycin requires careful consideration of patient‑specific factors before use.

  • Pregnancy: Category C; use only if potential benefits justify the risk.
  • Renal impairment: dose adjustment may be necessary in severe dysfunction.
  • Hepatic impairment: monitor liver function tests during therapy.
  • Drug interactions: review concomitant medications for potential QT‑prolonging agents.
  • QT prolongation risk: avoid in patients with known prolonged QT interval.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Clarithromycin can alter the plasma levels of several co‑administered drugs.

Major Interactions (Avoid)

  • Erythromycin and other macrolides: additive QT‑prolongation risk.
  • Cisapride: may cause serious cardiac events.
  • Pimozide: increased plasma concentrations leading to toxicity.
  • Terfenadine: heightened risk of arrhythmia.
  • St. John’s wort: reduces clarithromycin exposure.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR and bleeding risk.
  • Theophylline: elevated levels can cause toxicity.
  • Carbamazepine: may decrease clarithromycin efficacy.
  • Statins (e.g., lovastatin): increased risk of myopathy.

Frequently Asked Questions

Kruklar, containing clarithromycin, is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, Helicobacter pylori infection as part of eradication therapy, and streptococcal pharyngitis. The specific indication depends on the prescriber’s assessment of the infection type and severity.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing the translocation step of peptide elongation. This action stops bacterial growth (bacteriostatic) and, at higher concentrations, can kill susceptible organisms (bactericidal), thereby resolving the infection.

The dosage of Kruklar is determined by the prescribing clinician based on the infection being treated, patient age, weight, renal and hepatic function, and other clinical factors. Only a qualified healthcare professional should set the appropriate regimen.

Clarithromycin is classified as Pregnancy Category C, meaning it should be used only if the potential benefit justifies the potential risk to the fetus. It passes into breast milk in small amounts; breastfeeding mothers should consult their physician before use.

To request Kruklar, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clarithromycin offers a broader spectrum against certain atypical pathogens and has a longer half‑life than erythromycin, allowing twice‑daily dosing. It also has fewer gastrointestinal side effects than some older macrolides, though drug‑interaction potential remains significant and must be evaluated.

Store Kruklar at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency throughout its shelf life.

Kruklar is taken orally, usually with or without food as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe allergic reactions (anaphylaxis), QT‑interval prolongation leading to potentially fatal arrhythmias, hepatic dysfunction, Clostridioides difficile‑associated colitis, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Patients with known hypersensitivity to clarithromycin or other macrolides, those with a history of significant QT prolongation, and individuals taking contraindicated drugs such as cisapride or pimozide should avoid Kruklar. Clinicians must also assess renal and hepatic function before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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