Product image of Kybernin (Antithrombin Iii) supplied by GNH India

Kybernin

Active Ingredient:
Antithrombin Iii
Origin:
EU

Kybernin (Antithrombin Iii)

Antithrombin III, the active ingredient in Kybernin, is an anticoagulant presented as an injectable solution for intravenous use. It is indicated for the prevention and treatment of thromboembolic events in patients with antithrombin deficiency and for managing heparin resistance.

GNH India supplies Kybernin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Csl Behring Gmbh

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Indications & Clinical Uses

Kybernin is used in the anticoagulation pathway to address deficiencies and resistance related to antithrombin activity.

  • Antithrombin deficiency: restores antithrombin levels to prevent clot formation.
  • Heparin resistance: enhances heparin efficacy by providing the necessary cofactor.
  • Cardiopulmonary bypass surgery: supports anticoagulation when endogenous antithrombin is insufficient.

How It Works

  • Antithrombin III binds to and inactivates thrombin and several serine proteases (including factor Xa) in the coagulation cascade. By restoring functional antithrombin activity, it reduces the conversion of fibrinogen to fibrin, thereby limiting clot formation and supporting the anticoagulant effect of heparin.

Side Effects

Kybernin may be associated with a range of adverse reactions following intravenous administration.

Common Side Effects

  • Infusion‑related fever or chills.
  • Mild hypotension during or shortly after infusion.
  • Localized erythema or swelling at the injection site.
  • Transient headache.

Serious or Rare Side Effects

  • Severe allergic reaction or anaphylaxis.
  • Significant bleeding or hemorrhage.
  • Thrombotic events despite therapy.
  • Acute renal impairment.
  • Development of antibodies against antithrombin.

Precautions & Warnings

Before using Kybernin, clinicians should consider several safety measures.

  • Monitor antithrombin activity: check plasma levels before and during therapy.
  • Assess bleeding risk: evaluate patient history of hemorrhage.
  • Caution in thrombosis history: avoid if recent thrombotic events occurred.
  • Concomitant anticoagulants: adjust doses of other agents to prevent over‑anticoagulation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kybernin can interact with other anticoagulant and antithrombotic agents.

Major Interactions (Avoid)

  • Concurrent high‑dose heparin: may cause excessive anticoagulation.
  • Direct thrombin inhibitors (e.g., dabigatran): increased risk of bleeding.

Moderate Interactions (Monitor Closely)

  • Warfarin: may require INR monitoring and dose adjustment.
  • Low molecular weight heparins: monitor anti‑Xa activity.
  • Antiplatelet agents (e.g., aspirin, clopidogrel): heightened bleeding tendency.

Frequently Asked Questions

Kybernin is an injectable antithrombin III concentrate used to prevent and treat thromboembolic events in patients with antithrombin deficiency and to manage heparin resistance during anticoagulant therapy.

Antithrombin III binds to thrombin and several serine proteases such as factor Xa, inactivating them and thereby reducing fibrin formation. This restores normal anticoagulant activity and enhances the effect of heparin.

The dosage of Kybernin is individualized. The prescribing clinician determines the amount and infusion rate based on the patient’s antithrombin level, weight, and clinical situation.

Safety data for Kybernin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Kybernin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and import documentation.

Kybernin provides direct replacement of antithrombin, which is essential for heparin activity. Unlike heparin alone, it can correct antithrombin deficiency and overcome heparin resistance, offering a targeted approach when standard anticoagulants are insufficient.

Kybernin must be stored at 2‑8 °C. Keep the vials refrigerated, protect them from light, and avoid freezing or shaking the solution to maintain product stability.

Kybernin is given as an intravenous infusion. The rate and duration are set by the prescriber, typically based on antithrombin activity monitoring and the clinical context.

Serious risks include severe allergic reactions (anaphylaxis), significant bleeding, and rare thrombotic events despite therapy. Patients should be monitored closely for any signs of these complications.

Kybernin is contraindicated in patients with known hypersensitivity to antithrombin III products, those with active major bleeding, or individuals for whom anticoagulation is contraindicated without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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