Product image of Kyleena (Levonorgestrel) supplied by GNH India

Kyleena

Active Ingredient:
Levonorgestrel
Origin:
EU

Kyleena (Levonorgestrel)

Levonorgestrel, the active ingredient in Kyleena, is a synthetic progestin presented as a 19.5 mg intrauterine system (IUS) for intrauterine placement. It provides continuous, hormone‑based contraception by releasing levonorgestrel locally within the uterus, thereby preventing pregnancy in women of reproductive age for up to five years.

GNH India supplies Kyleena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and offering regulatory‑supported distribution across multiple markets.

Manufacturer / TM Owner

Bayer Ag

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Kyleena, a levonorgestrel‑releasing intrauterine system, is indicated for hormonal contraception.

  • Contraception (prevention of pregnancy): provides highly effective, reversible birth control for up to five years.
  • Long‑acting reversible contraception (LARC): eliminates the need for daily or monthly dosing.
  • User convenience: reduces reliance on user‑dependent methods and improves adherence.

How It Works

  • Levonorgestrel is continuously released from the intrauterine system, where it thickens cervical mucus, impairs sperm motility and function, suppresses endometrial proliferation, and may inhibit ovulation. These combined actions create an environment that prevents fertilisation and implantation, delivering reliable, long‑term contraception.

Side Effects

Kyleena may cause a range of adverse reactions. The majority are mild and resolve with continued use.

Common Side Effects

  • Irregular vaginal bleeding or spotting.
  • Amenorrhea (absence of periods).
  • Pelvic or cramping pain after insertion.
  • Breast tenderness or mild hormonal changes.

Serious or Rare Side Effects

  • Uterine perforation during insertion.
  • IUS expulsion or displacement.
  • Pelvic inflammatory infection.
  • Ectopic pregnancy if contraception fails.
  • Severe allergic reaction (e.g., rash, swelling).

Precautions & Warnings

Before prescribing Kyleena, clinicians should consider several safety measures.

  • Pregnancy screening: confirm the patient is not pregnant prior to insertion.
  • Uterine assessment: evaluate for fibroids, congenital anomalies, or scarring.
  • Infection control: treat any active pelvic infection before placement.
  • Medication review: identify drugs that may reduce contraceptive efficacy.
  • Bleeding counseling: inform patients about possible changes in menstrual patterns.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel released from Kyleena can be affected by other medicines.

Major Interactions (Avoid)

  • CYP3A4 inducers (e.g., rifampicin, phenytoin): may markedly lower levonorgestrel levels.
  • Anticonvulsants (e.g., carbamazepine, phenobarbital): can reduce contraceptive effectiveness.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole, itraconazole): may increase hormone exposure.
  • Certain antibiotics (e.g., tetracycline, metronidazole): limited evidence, monitor for breakthrough bleeding.
  • Herbal supplements (e.g., St. John’s wort): potential to alter hormone metabolism.

Frequently Asked Questions

Kyleena is a levonorgestrel‑releasing intrauterine system indicated for the prevention of pregnancy. It provides a highly effective, reversible form of contraception that can remain in place for up to five years, making it a long‑acting reversible contraceptive option for women of reproductive age.

Levonorgestrel released from the IUS thickens cervical mucus, reduces sperm motility, suppresses the growth of the uterine lining, and may inhibit ovulation. These mechanisms together create an environment that prevents fertilisation and implantation, delivering reliable contraception.

The dosage of Kyleena is determined by the prescriber based on the approved 19.5 mg levonorgestrel intrauterine system. The device is inserted by a qualified healthcare professional and remains effective for up to five years without the need for daily dosing.

Kyleena must not be used by women who are pregnant; it is intended for contraception before pregnancy occurs. If pregnancy is confirmed, the device should be removed. Limited data are available for breastfeeding, and clinicians should weigh benefits against potential risks before insertion.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kyleena contains 19.5 mg levonorgestrel, offering a slightly lower hormone dose than some alternatives while still providing up to five years of protection. Compared with copper IUDs, it may cause less menstrual bleeding but does not protect against sexually transmitted infections.

Kyleena should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its integrity until insertion by a qualified professional.

Kyleena is a sterile intrauterine system that is inserted through the cervix into the uterine cavity by a trained healthcare provider. The procedure is performed in a clinical setting using aseptic technique, and the device remains in place for up to five years.

Serious risks, though uncommon, include uterine perforation during insertion, expulsion of the device, pelvic inflammatory infection, and ectopic pregnancy if contraception fails. Patients should seek immediate medical attention for severe abdominal pain, abnormal bleeding or signs of infection.

Kyleena is contraindicated in women who are pregnant, have active pelvic infection, unexplained vaginal bleeding, uterine anomalies, or a known hypersensitivity to levonorgestrel. It should also be avoided in patients with a history of uterine perforation or certain cancers of the reproductive tract.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.