Product image of Kyleena (Levonorgestrel) supplied by GNH India

Kyleena

Active Ingredient:
Levonorgestrel
Origin:
EU

Kyleena (Levonorgestrel)

Levonorgestrel, the active ingredient in Kyleena, is a progestogen presented as a 52 mg intrauterine system for intrauterine use. It provides hormonal contraception for women of reproductive age, delivering continuous levonorgestrel release to prevent pregnancy.
GNH India supplies Kyleena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Ag

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Indications & Clinical Uses

Kyleena, a levonorgestrel‑releasing intrauterine system, is used within the hormonal contraceptive pathway to prevent pregnancy.

  • Contraception (up to 5 years): provides highly effective reversible birth control for up to five years of use.
  • Family planning: offers long‑term, maintenance‑free contraception without daily dosing.
  • Hormonal contraception: delivers continuous progestogen effect to suppress ovulation and alter cervical mucus.

How It Works

  • Kyleena releases levonorgestrel locally within the uterine cavity. The hormone thickens cervical mucus, reduces sperm motility and viability, suppresses endometrial proliferation, and may inhibit ovulation, thereby preventing fertilisation and implantation of a fertilised egg.

Side Effects

Common Side Effects

  • Irregular vaginal bleeding or spotting.
  • Amenorrhea (absence of periods).
  • Pelvic or cramping pain after insertion.
  • Breast tenderness.
  • Mood changes or headache.

Serious or Rare Side Effects

  • Uterine perforation during insertion.
  • IUS expulsion.
  • Pelvic inflammatory infection.
  • Ectopic pregnancy if contraception fails.
  • Ovarian cyst formation.
  • Severe allergic reaction (anaphylaxis).

Precautions & Warnings

Before insertion, clinicians should assess patient suitability and counsel on risks.

  • Pregnancy contraindicated: avoid use in pregnant women.
  • Uterine abnormalities: screen for fibroids, malformations, or scarring.
  • History of pelvic infection: evaluate and treat prior infections.
  • Smoking over age 35: advise cessation due to increased cardiovascular risk.
  • Breastfeeding: discuss benefits and alternatives with the prescriber.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel may interact with drugs that alter its metabolism or hormonal balance.

Major Interactions (Avoid)

  • Rifampin, carbamazepine, phenytoin, phenobarbital: enzyme inducers that reduce levonorgestrel levels.
  • St. John’s wort: may decrease contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antifungal agents such as ketoconazole: may increase hormone concentrations.
  • Certain antiretrovirals (e.g., efavirenz): may modestly lower effectiveness.
  • Combined hormonal contraceptives: assess cumulative hormonal exposure.
  • Hormone‑sensitive conditions (e.g., endometriosis): monitor symptom changes.

Frequently Asked Questions

Kyleena is a levonorgestrel‑releasing intrauterine system indicated for hormonal contraception, providing up to five years of highly effective, reversible birth control for women of reproductive age.

Levonorgestrel released from Kyleena thickens cervical mucus, reduces sperm motility, suppresses the endometrium, and may inhibit ovulation, together preventing fertilisation and implantation.

The prescribed dose of Kyleena is determined by the healthcare professional who inserts the 52 mg intrauterine system; patients should follow the prescriber’s instructions without self‑adjustment.

Kyleena is contraindicated in pregnancy. Women who become pregnant while using the device should seek medical advice. Limited data exist for breastfeeding; clinicians should evaluate risks and benefits before use.

Enquiries are submitted via the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with copper IUDs, Kyleena releases a progestogen, often resulting in lighter menstrual bleeding and fewer systemic hormonal effects. Its 52 mg levonorgestrel load offers up to five years of protection, whereas some alternatives may have different durations or hormone‑free mechanisms.

Store Kyleena at room temperature, preferably below 25 °C, in its original packaging. Protect the device from moisture, direct sunlight and physical damage until it is inserted by a qualified clinician.

Kyleena is inserted into the uterine cavity by a trained healthcare professional using a sterile applicator. The procedure is performed in a clinical setting under aseptic conditions.

Serious risks include uterine perforation during insertion, device expulsion, pelvic inflammatory infection, ectopic pregnancy if contraception fails, and severe allergic reactions. Patients should seek immediate medical attention if they experience severe abdominal pain, fever, or unusual bleeding.

Kyleena should not be used by women who are pregnant, have active pelvic infection, untreated cervical or uterine cancer, unexplained vaginal bleeding, or known hypersensitivity to levonorgestrel or any component of the device.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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