Product image of Kyleena (Levonorgestrel) supplied by GNH India

Kyleena

Active Ingredient:
Levonorgestrel
Origin:
EU

Kyleena (Levonorgestrel)

Levonorgestrel, the active ingredient in Kyleena, is a Progestin (hormonal contraceptive) presented as a 19.5 mg intrauterine system for intrauterine use. It prevents pregnancy by providing continuous local hormone release that suppresses endometrial growth, thickens cervical mucus and impairs sperm function.

GNH India supplies Kyleena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Portugal Lda

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Indications & Clinical Uses

Kyleena, a levonorgestrel‑releasing intrauterine system, is indicated for hormonal contraception.

  • Contraception (prevention of pregnancy): Provides up to five years of highly effective birth control for women of reproductive age.

How It Works

  • Kyleena releases levonorgestrel directly into the uterine cavity. The progestin binds to progesterone receptors in the endometrium, inhibiting its proliferation, while also thickening cervical mucus and reducing tubal motility. These combined actions create an environment hostile to sperm penetration and implantation, thereby preventing pregnancy.

Side Effects

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Pelvic or abdominal pain
  • Cramping during or after insertion
  • Headache
  • Breast tenderness

Serious or Rare Side Effects

  • Uterine perforation during insertion
  • Expulsion of the device
  • Pelvic inflammatory disease or infection
  • Ectopic pregnancy if pregnancy occurs
  • Allergic reaction to device materials
  • Severe abdominal pain requiring medical evaluation

Precautions & Warnings

Before using Kyleena, consider the following precautions.

  • Pregnancy testing: Confirm the patient is not pregnant prior to insertion.
  • Breastfeeding: Discuss potential risks and benefits with a healthcare provider.
  • History of pelvic infection: Evaluate and treat any active infection before device placement.
  • Uterine abnormalities: Contraindicated in cases of significant uterine malformations.
  • Smoking: Advise cessation, especially in women over 35, to reduce cardiovascular risk.
  • Store at room temperature: Keep the device in its original packaging, protect from moisture and extreme heat.

Avoid Interactions

Kyleena may interact with other medications that affect hormone metabolism.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): May reduce levonorgestrel efficacy.
  • Rifampin or rifabutin: Can lower hormone levels and increase risk of contraceptive failure.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): May slightly diminish contraceptive effectiveness.
  • Herbal supplements such as St. John’s wort: Potential to reduce hormone levels.
  • Concurrent hormonal therapy: Monitor for additive hormonal effects and adjust as needed.

Frequently Asked Questions

Kyleena is a levonorgestrel‑releasing intrauterine system designed to provide long‑term hormonal contraception. It is inserted into the uterus and can prevent pregnancy for up to five years, offering a highly effective, reversible birth control option for women of reproductive age.

Levonorgestrel released from Kyleena acts locally on the uterine lining and cervical mucus. It suppresses endometrial growth, thickens cervical mucus to block sperm entry, and reduces tubal motility, creating conditions that prevent fertilisation and implantation.

The dosing regimen for Kyleena is determined by a qualified prescriber. The device contains a fixed amount of 19.5 mg levonorgestrel and is inserted once, providing continuous contraceptive effect for up to five years without the need for daily dosing.

Kyleena is contraindicated in pregnancy (Category X) and should not be used by women who are or may become pregnant. For breastfeeding women, the device may be used after discussion with a healthcare professional, as levonorgestrel is excreted in low amounts in breast milk.

To order Kyleena, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with copper IUDs, Kyleena releases a progestin rather than copper, resulting in fewer menstrual changes and a lower incidence of heavy bleeding. Its 19.5 mg levonorgestrel load offers up to five years of protection, whereas some alternatives may have different hormone doses or durations.

Kyleena should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its integrity until the time of insertion.

Kyleena is administered by a trained healthcare professional who inserts the intrauterine system through the cervix into the uterine cavity. The procedure is performed in a clinical setting under sterile conditions, and the device remains in place for up to five years unless removal is required.

Serious risks include uterine perforation during insertion, expulsion of the device, pelvic inflammatory disease, and the rare possibility of ectopic pregnancy if conception occurs. Patients should seek immediate medical attention if they experience severe abdominal pain, abnormal bleeding or signs of infection.

Kyleena is contraindicated for women who are pregnant, have active pelvic infections, known or suspected uterine anomalies, unexplained vaginal bleeding, or a history of breast cancer. It should also be avoided by individuals with hypersensitivity to levonorgestrel or any component of the device.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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