Product image of Kynmobi (Apomorphine Hydrochloride Hemihydrate) supplied by GNH India

Kynmobi

Active Ingredient:
Apomorphine Hydrochloride Hemihydrate
Origin:
EU

Kynmobi (Apomorphine Hydrochloride Hemihydrate)

Apomorphine hydrochloride, the active ingredient in Kynmobi, is a dopamine agonist presented as a sublingual tablet for sublingual use. It restores dopaminergic stimulation during OFF episodes in Parkinson's disease.
GNH India supplies Kynmobi as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bial - Portela & Cª , Sa

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Indications & Clinical Uses

Kynmobi, a dopamine agonist, acts on the dopaminergic pathway to manage motor fluctuations in Parkinson's disease.

  • Parkinson's disease (OFF episodes): Reduces the frequency and duration of OFF periods.
  • Parkinson's disease (early morning OFF): Improves motor function upon waking.
  • Parkinson's disease (motor fluctuations): Enhances overall motor performance during fluctuations.

How It Works

  • Apomorphine hydrochloride directly stimulates dopamine D1 and D2 receptors in the central nervous system, providing rapid dopaminergic activation that compensates for the loss of endogenous dopamine during OFF episodes in Parkinson's disease.

Side Effects

Common Side Effects

  • Nausea and vomiting
  • Dizziness or light‑headedness
  • Orthostatic hypotension
  • Headache
  • Somnolence or fatigue
  • Dry mouth

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Hallucinations or psychosis
  • Impulse control disorders
  • Severe nausea or persistent vomiting
  • Cardiac arrhythmias
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

Patients should be monitored closely when initiating therapy.

  • Dose titration: Start with a low dose and increase gradually under medical supervision.
  • Cardiovascular monitoring: Observe for hypotension and syncope, especially after the first dose.
  • Neuropsychiatric assessment: Watch for hallucinations, confusion, or impulse control changes.
  • Contraindications: Avoid in individuals with known hypersensitivity to apomorphine or its excipients.
  • Pregnancy and lactation: Safety not established; use only if benefits outweigh potential risks.
  • Store at ambient temperature: Keep in the original container, protect from moisture and heat.

Avoid Interactions

Apomorphine may interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: Risk of hypertensive crisis.
  • Antiemetics such as metoclopramide or domperidone: Antagonize dopaminergic effect.
  • Antipsychotics (e.g., haloperidol, risperidone): Block dopamine receptors, reducing efficacy.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: Additive hypotensive effect.
  • SSRIs or SNRIs: May increase risk of serotonin syndrome.
  • Alcohol: Can enhance central nervous system depression.

Frequently Asked Questions

Kynmobi is prescribed to treat OFF episodes in patients with Parkinson's disease. By providing rapid dopaminergic stimulation, it helps reduce the duration and severity of motor fluctuations that occur when standard oral therapy wears off.

Apomorphine, the active ingredient in Kynmobi, directly activates dopamine D1 and D2 receptors in the brain. This mimics the action of natural dopamine, quickly restoring motor function during periods when endogenous dopamine levels are insufficient.

The specific dose of Kynmobi is determined by the prescribing physician based on the individual patient's clinical condition, response, and tolerability. Dosage adjustments are made under medical supervision to achieve optimal control of OFF episodes.

Safety data for Kynmobi in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Kynmobi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team will then provide pricing, availability, shipping details (including cold‑chain if needed) and assist with import documentation.

Kynmobi provides rapid, sublingual delivery of apomorphine, offering quicker onset of action compared with oral levodopa formulations. Unlike injectable apomorphine, the sublingual tablet is non‑invasive, making it convenient for patients who need prompt relief from OFF episodes without injections.

Kynmobi should be stored at ambient temperature, below 25 °C. Keep the tablets in the original blister pack, protect them from moisture, direct sunlight and excessive heat to maintain stability and potency.

Kynmobi is taken as a sublingual tablet placed under the tongue. The tablet should be allowed to dissolve completely without swallowing, and the patient should remain upright for several minutes to ensure optimal absorption.

Serious risks include severe hypotension, syncope, hallucinations, impulse control disorders, and rare cardiac arrhythmias. Patients should be monitored closely, especially during dose initiation, and any concerning symptoms should be reported to a healthcare provider immediately.

Kynmobi is contraindicated in individuals with known hypersensitivity to apomorphine or any tablet excipients, and in patients with uncontrolled cardiovascular disease or severe psychiatric conditions where dopamine agonists could exacerbate symptoms.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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