Product image of Kynmobi (Apomorphine Hydrochloride Hemihydrate) supplied by GNH India

Kynmobi

Active Ingredient:
Apomorphine Hydrochloride Hemihydrate
Origin:
EU

Kynmobi (Apomorphine Hydrochloride Hemihydrate)

Apomorphine Hydrochloride Hemihydrate, the active ingredient in Kynmobi, is a dopamine agonist presented as a sublingual formulation for sublingual use. It is employed to manage OFF episodes in patients with Parkinson's disease, helping to restore motor function during periods of reduced dopaminergic activity.

GNH India supplies Kynmobi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand, including export to EU and Asian markets.

Manufacturer / TM Owner

Bial - Portela & Cª , Sa

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Indications & Clinical Uses

Kynmobi is a dopamine agonist used within the Parkinson's disease therapeutic pathway to improve motor control.

  • OFF episodes in Parkinson's disease: restores motor function during periods of reduced dopaminergic activity.
  • Motor fluctuations in Parkinson's disease: helps smooth transitions between ON and OFF states.
  • Adjunct therapy in Parkinson's disease: used alongside levodopa to enhance overall symptom control.

How It Works

  • Apomorphine Hydrochloride Hemihydrate acts as a non‑selective dopamine receptor agonist, stimulating both D1 and D2 receptors in the central nervous system. By directly activating these receptors, it bypasses the need for endogenous dopamine, thereby improving basal ganglia signaling and reducing motor deficits associated with Parkinson's disease.

Side Effects

Apomorphine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea
  • Dizziness
  • Headache
  • Orthostatic hypotension
  • Somnolence
  • Dry mouth

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Hallucinations or psychosis
  • Impulse control disorders
  • Severe nausea or vomiting
  • Allergic reactions including rash or anaphylaxis
  • Cardiac arrhythmias

Precautions & Warnings

When prescribing apomorphine, clinicians should observe several safety measures.

  • Dose titration: start low and increase gradually as directed by the prescriber.
  • Orthostatic hypotension: monitor blood pressure when changing positions.
  • Nausea management: consider antiemetic pre‑treatment if needed.
  • Psychiatric effects: watch for hallucinations, mood changes, or impulse control issues.
  • Contraindications: avoid in patients with known hypersensitivity to apomorphine.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Apomorphine can interact with other medicines, requiring careful assessment.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Dopamine antagonists (e.g., antipsychotics): may block therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect.
  • Antiemetics such as metoclopramide: may increase dopaminergic activity.
  • Alcohol: may enhance dizziness and sedation.

Frequently Asked Questions

Kynmobi contains apomorphine hydrochloride hemihydrate and is prescribed to treat OFF episodes in patients with Parkinson's disease. It helps restore motor function during periods when standard dopaminergic therapy is insufficient.

Apomorphine is a non‑selective dopamine agonist that stimulates D1 and D2 receptors in the brain. By directly activating these receptors, it compensates for low dopamine levels, improving the signaling pathways that control movement.

The dose of Kynmobi is individualized. A qualified prescriber determines the appropriate starting dose and any subsequent titration based on the patient’s clinical response and tolerance.

Safety data for apomorphine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a healthcare professional.

To request Kynmobi, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kynmobi offers a rapid‑acting, sublingual route that can provide quicker relief compared with oral levodopa formulations. Unlike injectable apomorphine, the sublingual form avoids needles and may be more convenient for patients requiring frequent dosing.

Kynmobi should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and excessive heat to maintain its stability.

Kynmobi is administered sublingually. The tablet or film is placed under the tongue and allowed to dissolve completely without swallowing, ensuring rapid absorption into the bloodstream.

Serious risks include severe hypotension, syncope, hallucinations, impulse control disorders, and rare allergic reactions. Patients should be monitored closely for these events, especially during dose initiation and titration.

Kynmobi is contraindicated in individuals with known hypersensitivity to apomorphine or any of its excipients, and in patients taking monoamine oxidase inhibitors. It should also be avoided in patients with uncontrolled cardiovascular disease or severe psychiatric conditions unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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