Product image of Kynteles (Vedolizumab ) 300mg Vials supplied by GNH India

Kynteles

Active Ingredient:
Vedolizumab
Form:
Vials
Brand:
Kynteles
Origin:
Austria

Kynteles (Vedolizumab Vials) 300mg

Vedolizumab, the active ingredient in Kynteles, is a humanized monoclonal antibody presented as a 300mg injection vial for intravenous use. It is used to treat moderately to severely active ulcerative colitis and Crohn’s disease in adults. GNH India supplies Kynteles as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Kynteles is a selective antagonist of the α4β7 integrin, which plays a crucial role in the inflammation process within the gut. By inhibiting the trafficking of lymphocytes to the gut, Vedolizumab helps reduce inflammation and improve symptoms in patients with chronic inflammatory bowel diseases.

Strength

300mg

Pack Size

1s

Storage

2-8°

Manufacturer / TM Owner

Takeda Austria Gmbh

1
Pack/s
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Indications & Clinical Uses

Kynteles is used to treat inflammatory bowel diseases by targeting the α4β7 integrin pathway.

  • Ulcerative colitis: Helps induce and maintain clinical remission, improve mucosal healing, and reduce the need for corticosteroids.
  • Crohn’s disease: Used to manage moderately to severely active disease, improving symptoms and reducing inflammation.
  • Pouchitis: May be used to treat moderate to severe active pouchitis, reducing inflammation and symptoms.

How It Works

  • Vedolizumab works by selectively binding to the α4β7 integrin on the surface of white blood cells. This binding inhibits the trafficking of these cells to the gut, reducing inflammation and the associated symptoms of inflammatory bowel diseases. By targeting this specific pathway, Vedolizumab minimizes systemic immune suppression, focusing its effects on the gastrointestinal tract.

Side Effects

Kynteles may cause various side effects, ranging from common to serious.

Common Side Effects

  • Nasopharyngitis
  • Headache
  • Arthralgia
  • Nausea
  • Fever
  • Upper respiratory tract infection
  • Fatigue
  • Cough
  • Back pain
  • Itching
  • Dizziness
  • Injection site reactions

Serious or Rare Side Effects

  • Severe infections, including tuberculosis
  • Progressive multifocal leukoencephalopathy (PML)
  • Allergic reactions, including anaphylaxis
  • Severe liver injury
  • Severe skin reactions

Precautions & Warnings

Kynteles should be used with caution in certain patient populations and conditions.

  • Allergy: Avoid if allergic to Vedolizumab or any of its components.
  • Infections: Use with caution in patients with active infections or a history of serious infections.
  • Tuberculosis: Screen for tuberculosis before starting treatment.
  • Liver or kidney disease: Monitor liver and kidney function regularly.
  • Immunosuppression: Use with caution in patients with a weakened immune system.
  • Pregnancy and breastfeeding: Safety has not been established; consult a doctor.
  • Children: Not recommended for use in children under 18 years of age.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kynteles may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects.

Major Interactions (Avoid)

  • Other immunosuppressants: Increased risk of infections.
  • Live vaccines: Avoid concurrent use due to potential for severe infections.
  • Biologics: Potential for increased immune-related adverse effects.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: Increased risk of infections and other side effects.
  • Immunomodulators: Monitor for signs of infection or other adverse effects.
  • Antibiotic therapy: Monitor for signs of infection or other adverse effects.

Frequently Asked Questions

Kynteles is used to treat moderately to severely active ulcerative colitis and Crohn’s disease in adults. It helps induce and maintain clinical remission, improve mucosal healing, and reduce the need for corticosteroids. Kynteles is also used to manage moderate to severe active pouchitis.

Vedolizumab works by selectively binding to the α4β7 integrin on the surface of white blood cells. This binding inhibits the trafficking of these cells to the gut, reducing inflammation and the associated symptoms of inflammatory bowel diseases. By targeting this specific pathway, Vedolizumab minimizes systemic immune suppression, focusing its effects on the gastrointestinal tract.

The usual dose of Kynteles is determined by a healthcare professional based on the patient’s condition and response to treatment. The typical dosing regimen involves an initial infusion followed by subsequent infusions at specified intervals. Always follow the prescription and instructions provided by your doctor.

The safety of Kynteles during pregnancy and breastfeeding has not been established. Pregnant or breastfeeding women should consult their doctor before using this medication to weigh the potential benefits and risks.

To order Kynteles from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will reply with pricing, availability, shipping, and the import paperwork.

Kynteles is a selective antagonist of the α4β7 integrin, focusing its effects on the gastrointestinal tract with minimal systemic immune suppression. Compared to other treatments like corticosteroids or broader immunosuppressants, Kynteles offers a targeted approach that may reduce the risk of systemic side effects. However, the choice of treatment depends on individual patient factors and should be discussed with a healthcare professional.

Kynteles should be stored at 2-8°C, kept refrigerated, protected from light, and not frozen or shaken. Proper storage is crucial to maintain the medication’s efficacy and safety. Always follow the storage instructions provided with the product.

Kynteles is administered as an intravenous infusion by a healthcare professional. The infusion is typically given over a period of time, and the patient is monitored during and after the infusion to ensure safety and efficacy. Self-administration is not recommended.

The most serious risks associated with Kynteles include severe infections, progressive multifocal leukoencephalopathy (PML), allergic reactions, severe liver injury, and severe skin reactions. Patients should be monitored closely for signs of these complications, and any concerns should be reported to a healthcare professional immediately.

Kynteles should not be used by individuals who are allergic to Vedolizumab or any of its components, those with active severe infections, or patients with a history of serious infections. It is also not recommended for children under 18 years of age, and its safety during pregnancy and breastfeeding has not been established. Always consult a healthcare professional before starting any new medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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