Product image of L-Thyroxin 100 1 A Pharma (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin 100 1 A Pharma

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin 100 1 A Pharma (Levothyroxine Sodium)

Levothyroxine sodium, the active ingredient in L-Thyroxin 100 1 A Pharma, is a thyroid hormone presented as a 100 µg oral tablet for oral use. It replaces deficient thyroid hormone and is indicated for the treatment of hypothyroidism and goiter in patients requiring hormone replacement.

GNH India supplies L-Thyroxin 100 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

Levothyroxine sodium is a synthetic thyroid hormone that acts on the hypothalamic‑pituitary‑thyroid axis to restore normal hormone levels.

  • Hypothyroidism: normalizes thyroid hormone concentrations, relieving fatigue, weight gain and cold intolerance.
  • Goiter: reduces thyroid gland enlargement by correcting hormone deficiency.
  • Post‑thyroidectomy thyroid hormone replacement: maintains metabolic function after surgical removal of the thyroid.

How It Works

  • Levothyroxine sodium is a synthetic analogue of the endogenous hormone thyroxine (T4). After oral absorption, it is converted in peripheral tissues to the active triiodothyronine (T3), binding to nuclear thyroid hormone receptors and modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth. By restoring circulating T4 levels, it re‑establishes feedback inhibition of the hypothalamic‑pituitary axis.

Side Effects

Levothyroxine sodium may cause adverse reactions, ranging from mild to severe, that should be monitored during therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Insomnia: difficulty falling or staying asleep.
  • Nervousness or tremor: mild increase in nervous system activity.
  • Sweating: increased perspiration without exertion.

Serious or Rare Side Effects

  • Chest pain or palpitations: possible sign of cardiac arrhythmia.
  • Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Hyperthyroidism symptoms: rapid weight loss, heat intolerance, or bone loss.

Precautions & Warnings

When prescribing levothyroxine sodium, clinicians should consider several precautionary measures to ensure safe and effective therapy.

  • Dose adjustment: monitor TSH and free T4 levels regularly and adjust dose accordingly.
  • Cardiovascular disease: initiate therapy at a low dose and titrate slowly in patients with coronary artery disease.
  • Elderly patients: consider reduced starting dose due to altered metabolism.
  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
  • Drug interactions: review concomitant medications that may affect absorption or hormone levels.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine sodium interacts with several medicines that can alter its absorption or pharmacodynamic effect.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: significantly reduce levothyroxine absorption.
  • Calcium supplements: bind the drug in the gut and decrease its bioavailability.
  • Iron salts: impair absorption when taken concurrently.

Moderate Interactions (Monitor Closely)

  • Warfarin: levothyroxine may enhance anticoagulant effect, requiring INR monitoring.
  • Amiodarone: can affect thyroid hormone synthesis and conversion, necessitating thyroid function tests.
  • Beta‑blockers: may mask symptoms of excess thyroid hormone, requiring careful clinical assessment.

Frequently Asked Questions

L-Thyroxin 100 contains levothyroxine sodium, a synthetic thyroid hormone used to treat hypothyroidism and to manage goiter. It replaces deficient thyroid hormone, helping to normalize metabolism, energy levels, and body temperature in patients whose thyroid does not produce enough hormone.

Levothyroxine sodium is an analogue of the natural hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. These hormones bind to nuclear thyroid receptors, regulating gene expression that controls basal metabolic rate, protein synthesis, and growth.

The appropriate dose of levothyroxine is individualized. A prescriber determines the exact amount based on the patient’s age, weight, cardiac status, and laboratory measurements of thyroid‑stimulating hormone (TSH) and free T4. Dose adjustments are made periodically to maintain target thyroid levels.

Levothyroxine is classified as a pregnancy category that requires careful risk‑benefit assessment. It is generally considered safe when the therapeutic benefit outweighs potential risks, as untreated hypothyroidism can harm both mother and fetus. Limited data are available for breastfeeding, and a clinician should evaluate each case.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Levothyroxine (T4) is the standard of care for most hypothyroidism cases because it provides stable, long‑acting hormone replacement. Alternatives such as liothyronine (T3) act more rapidly but have a shorter half‑life and may cause more fluctuations. Combination therapy is sometimes used, but levothyroxine alone remains the most widely prescribed option.

Store the tablets at room temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, heat, and direct sunlight. Do not refrigerate or freeze the product, and keep it out of reach of children.

L-Thyroxin 100 is taken orally, usually on an empty stomach with a full glass of water, at least 30‑60 minutes before breakfast. Swallow the tablet whole; do not crush or chew. Consistency in timing and relation to meals helps maintain stable absorption.

Serious risks include cardiac arrhythmias, especially in patients with underlying heart disease, and symptoms of overt hyperthyroidism such as chest pain, rapid heart rate, severe weight loss, or bone loss. An allergic reaction, though rare, can manifest as rash, swelling, or anaphylaxis and requires immediate medical attention.

Levothyroxine should be avoided in patients with untreated adrenal insufficiency, acute myocardial infarction, or untreated thyrotoxicosis. Individuals with known hypersensitivity to levothyroxine or any excipients in the tablet formulation should also refrain from using the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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