Product image of L-Thyroxin 112 1 A Pharma (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin 112 1 A Pharma

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin 112 1 A Pharma (Levothyroxine Sodium)

Levothyroxine Sodium, the active ingredient in L-Thyroxin 112 1 A Pharma, is a thyroid hormone presented as a tablet for oral use. It replaces deficient thyroid hormone in patients with hypothyroidism, supporting normal metabolic activity.

GNH India supplies L-Thyroxin 112 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to global quality standards and provides reliable sourcing for regulated markets. With a focus on product integrity and timely delivery, GNH India supports the therapeutic needs of patients across multiple continents.

Manufacturer / TM Owner

1 A Pharma Gmbh

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Indications & Clinical Uses

L-Thyroxin 112 is used to treat conditions related to thyroid hormone deficiency.

  • Hypothyroidism: restores normal metabolic rate by supplying synthetic T4 to replace insufficient endogenous hormone.
  • Post‑thyroidectomy hormone replacement: provides necessary thyroid hormone after surgical removal of the thyroid gland.
  • Congenital hypothyroidism: supplies thyroid hormone to infants born with inadequate thyroid function, supporting growth and development.

How It Works

  • Levothyroxine sodium is a synthetic analogue of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. The hormone binds to nuclear thyroid hormone receptors, regulating transcription of genes involved in basal metabolic rate, protein synthesis, and growth. By replenishing deficient hormone levels, it normalizes metabolic processes throughout the body.

Side Effects

Levothyroxine sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache
  • Fatigue
  • Nausea
  • Weight loss
  • Palpitations
  • Insomnia

Serious or Rare Side Effects

  • Cardiac arrhythmia
  • Angina or myocardial infarction
  • Severe allergic reaction (anaphylaxis)
  • Bone loss (osteoporosis) with long‑term high dose
  • Hyperthyroidism symptoms such as tachycardia and tremor
  • Acute hepatic dysfunction (very rare)

Precautions & Warnings

When prescribing levothyroxine, clinicians should consider several safety measures to ensure optimal therapy.

  • Dose titration: adjust the dose based on thyroid function tests and clinical response.
  • Cardiovascular monitoring: assess for angina or arrhythmias, especially in elderly patients.
  • Drug absorption: separate administration from calcium, iron, or antacid products by at least 4 hours.
  • Pregnancy and lactation: use only if benefits outweigh potential risks and monitor maternal thyroid status closely.
  • Thyroid function monitoring: check serum TSH and free T4 levels 6–8 weeks after dose changes.
  • Store at ambient temperature: keep tablets in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine interacts with several medicines that can alter its absorption or effect.

Major Interactions (Avoid)

  • Calcium carbonate or calcium supplements: markedly reduce levothyroxine absorption.
  • Iron salts (ferrous sulfate): significantly decrease absorption when taken concurrently.
  • Antacids containing aluminum or magnesium: impair absorption.
  • Rifampin and other enzyme inducers: increase metabolism, reducing therapeutic levels.
  • Amiodarone: may cause thyroid dysfunction, requiring close monitoring.

Moderate Interactions (Monitor Closely)

  • Warfarin: levothyroxine may enhance anticoagulant effect, monitor INR.
  • Antidepressants (SSRIs): may affect thyroid hormone levels, monitor clinical response.
  • Cholesterol‑lowering agents (e.g., cholestyramine): can bind levothyroxine, reduce efficacy.
  • Oral contraceptives: may increase levothyroxine binding, dose adjustment may be needed.

Frequently Asked Questions

L-Thyroxin 112 contains levothyroxine sodium and is prescribed to replace deficient thyroid hormone in patients with hypothyroidism, to provide hormone replacement after thyroidectomy, and to treat congenital hypothyroidism in infants, thereby normalizing metabolic function.

Levothyroxine is a synthetic form of the natural hormone thyroxine (T4). After oral absorption it is converted to the active hormone triiodothyronine (T3) in peripheral tissues, binds to nuclear thyroid receptors, and regulates gene expression that controls basal metabolic rate, protein synthesis, and growth.

The appropriate dose of L-Thyroxin 112 is individualized. A prescribing clinician determines the starting amount based on the patient’s age, weight, severity of hormone deficiency, and laboratory thyroid function tests, then adjusts the dose according to follow‑up results.

Safety data for levothyroxine in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. The drug may be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and thyroid status should be closely monitored.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

The primary alternative to levothyroxine is liothyronine (synthetic T3) or combination T4/T3 preparations. Levothyroxine provides a stable, long‑acting source of T4, which is converted to T3 as needed, offering more predictable dosing and fewer peaks compared with direct T3 therapy, which may cause rapid fluctuations in hormone levels.

L-Thyroxin 112 tablets should be stored at ambient temperature, below 25 °C, in the original blister or bottle, protected from moisture, heat and direct sunlight. Keep the container tightly closed and out of reach of children.

The medication is taken orally, usually on an empty stomach 30‑60 minutes before breakfast with a full glass of water. It should not be crushed or chewed, and other oral products such as calcium, iron or antacids should be spaced at least four hours apart to avoid absorption interference.

Serious adverse events include cardiac arrhythmias, angina, myocardial infarction, severe allergic reactions, and symptoms of overt hyperthyroidism such as rapid heart rate, tremor, and weight loss. Long‑term high‑dose therapy may also increase the risk of osteoporosis, especially in post‑menopausal women.

Levothyroxine is contraindicated in patients with known hypersensitivity to levothyroxine or any of the tablet excipients. Caution is advised in individuals with untreated adrenal insufficiency, acute myocardial infarction, or uncorrected thyrotoxicosis, as the drug may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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