Product image of L-Thyroxin 25 1 A Pharma (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin 25 1 A Pharma

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin 25 1 A Pharma (Levothyroxine Sodium)

Levothyroxine Sodium, the active ingredient in L-Thyroxin 25 1 A Pharma, is a thyroid hormone replacement presented as a 25 µg tablet for oral use. It treats hypothyroidism and related thyroid hormone deficiencies in adults and children.

GNH India supplies L-Thyroxin 25 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

Levothyroxine is used to restore normal thyroid hormone activity in conditions affecting the thyroid gland.

  • Hypothyroidism: restores normal hormone levels, relieving fatigue, weight gain, and cold intolerance.
  • Goiter: reduces TSH stimulation, helping shrink an enlarged thyroid.
  • Post‑thyroidectomy or radioactive iodine therapy: provides necessary thyroxine to maintain metabolic function.

How It Works

  • Levothyroxine is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it enters the bloodstream, binds to nuclear thyroid hormone receptors, and modulates gene transcription. This restores normal metabolic rate, protein synthesis, and thermogenesis, compensating for deficient endogenous hormone production.

Side Effects

Levothyroxine may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Insomnia: difficulty falling or staying asleep.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Weight loss: unintended reduction in body weight.
  • Sweating: increased perspiration.
  • Tremor: fine shaking of hands or limbs.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or swelling.
  • Angioedema: rapid swelling of face, lips, or throat.
  • Chest pain: possible sign of cardiac strain.
  • Arrhythmia: abnormal heart rhythm.
  • Osteoporosis: reduced bone density with long‑term excess.
  • Severe hyperthyroidism: symptoms of over‑replacement such as heat intolerance and anxiety.

Precautions & Warnings

Levothyroxine requires careful monitoring and individualized dosing.

  • Dose titration: adjust based on serum TSH and clinical response.
  • Cardiovascular disease: monitor for tachycardia, angina, or arrhythmias.
  • Pregnancy: use only when benefits outweigh potential risks.
  • Elderly patients: initiate therapy at lower doses to avoid cardiac stress.
  • Drug interactions: review concomitant medications for absorption or metabolic effects.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Levothyroxine absorption and activity can be altered by several medicines.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levothyroxine absorption.
  • Calcium supplements: impair intestinal uptake of the drug.
  • Iron preparations: decrease bioavailability when taken together.
  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Amiodarone: can modify thyroid hormone metabolism.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of excess thyroid hormone.
  • SSRIs: potential for increased serotonergic activity when thyroid levels rise.
  • Diabetes medications: thyroid hormone may affect glucose control, necessitating dose adjustments.

Frequently Asked Questions

L-Thyroxin 25 1 A Pharma contains levothyroxine sodium, a synthetic thyroid hormone used to replace deficient endogenous hormone in patients with hypothyroidism, to manage goiter, and to provide hormone replacement after thyroidectomy or radioactive iodine therapy.

Levothyroxine is converted to the active hormone triiodothyronine (T3) after absorption. It binds to nuclear thyroid hormone receptors, influencing gene expression that regulates metabolism, heart rate, temperature, and protein synthesis, thereby normalizing the metabolic disturbances caused by low thyroid hormone levels.

The appropriate dose is individualized and determined by the prescribing clinician based on the patient’s serum TSH levels, age, weight, cardiac status, and response to therapy. The prescriber will adjust the dose to achieve optimal thyroid function.

Levothyroxine is generally considered safe in pregnancy when the benefits outweigh potential risks, as untreated hypothyroidism can harm both mother and fetus. It is also compatible with breastfeeding, but dosing may need adjustment and should be monitored by a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

L-Thyroxin provides levothyroxine sodium in a 25 µg tablet, comparable to other generic levothyroxine formulations. Differences may lie in excipients, bioavailability, and regulatory approvals, but the active ingredient and therapeutic effect are essentially the same across approved products.

Store the tablets at ambient temperature, preferably below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use if the packaging is damaged.

L-Thyroxin is taken orally, usually on an empty stomach 30‑60 minutes before breakfast. Swallow the tablet whole with a glass of water; do not crush or chew it, as this may affect absorption.

Serious risks include excessive dosing leading to hyperthyroidism, which can cause cardiac arrhythmias, angina, bone loss, and in rare cases, allergic reactions such as angioedema. Regular monitoring of thyroid function tests helps mitigate these risks.

Patients with untreated adrenal insufficiency, acute myocardial infarction, or known hypersensitivity to levothyroxine or any tablet excipients should avoid using this product. Clinicians should also exercise caution in patients with cardiovascular disease, the elderly, and pregnant women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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