Product image of L-Thyroxin 88 1 A Pharma (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin 88 1 A Pharma

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin 88 1 A Pharma (Levothyroxine Sodium)

Levothyroxine sodium, the active ingredient in L-Thyroxin 88 1 A Pharma, is a thyroid hormone presented as an oral tablet for oral use. It replaces deficient thyroid hormone and is used to treat hypothyroidism, goiter, and as thyroid hormone replacement therapy in patients with impaired thyroid function.

GNH India supplies L-Thyroxin 88 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

L-Thyroxin 88 is a synthetic thyroid hormone used to manage conditions related to low thyroid activity.

  • Hypothyroidism: restores normal thyroid hormone levels and alleviates symptoms such as fatigue and weight gain.
  • Goiter: reduces thyroid gland enlargement by normalising hormone feedback.
  • Thyroid hormone replacement therapy: maintains metabolic rate and growth in patients lacking endogenous hormone.

How It Works

  • Levothyroxine sodium is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active triiodothyronine (T3) within peripheral tissues. The hormone binds nuclear thyroid receptors, regulating gene transcription that controls basal metabolic rate, protein synthesis, and growth. By restoring normal hormone concentrations, it normalises the hypothalamic‑pituitary‑thyroid axis.

Side Effects

Adverse reactions may occur with levothyroxine therapy and vary in frequency.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Fatigue: persistent tiredness.
  • Weight gain: increase in body weight.
  • Hair loss: temporary thinning of scalp hair.
  • Insomnia: difficulty falling or staying asleep.
  • Gastrointestinal upset: nausea or abdominal discomfort.

Serious or Rare Side Effects

  • Allergic reaction: rash, angioedema, or anaphylaxis.
  • Chest pain: may indicate cardiac strain.
  • Arrhythmia: irregular heart rhythm.
  • Severe bone loss: increased risk of osteoporosis.
  • Thyrotoxicosis: symptoms of excess thyroid hormone.
  • Adrenal insufficiency: exacerbation of adrenal crisis.

Precautions & Warnings

Before initiating therapy, several safety considerations should be reviewed.

  • Dose adjustment: monitor TSH and free T4 levels regularly to individualise dosing.
  • Cardiovascular disease: use caution in patients with coronary artery disease or arrhythmias.
  • Pregnancy: assess risk‑benefit; dosage may need adjustment.
  • Elderly: start with lower doses and titrate slowly.
  • Drug interactions: review concomitant medications that may affect absorption or metabolism.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Levothyroxine may interact with several medicines, affecting its absorption or action.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levothyroxine absorption.
  • Iron supplements: decrease absorption when taken concurrently.
  • Calcium supplements: lower bioavailability of levothyroxine.

Moderate Interactions (Monitor Closely)

  • Cholestyramine: may bind the drug and reduce its effect.
  • Orlistat: can diminish levothyroxine absorption.
  • Selective serotonin reuptake inhibitors (SSRIs): may alter thyroid hormone levels.

Frequently Asked Questions

L-Thyroxin 88 contains levothyroxine sodium, a synthetic thyroid hormone used to treat hypothyroidism, manage goiter, and provide hormone replacement in patients whose thyroid does not produce sufficient hormone. It helps normalise metabolism, energy levels, and growth processes.

Levothyroxine sodium is absorbed from the gastrointestinal tract and converted to the active hormone triiodothyronine (T3) in peripheral tissues. It binds to nuclear thyroid receptors, influencing gene transcription that regulates basal metabolic rate, protein synthesis, and development, thereby compensating for deficient endogenous hormone.

The appropriate dose of L-Thyroxin 88 is determined individually by a qualified prescriber based on factors such as age, weight, severity of thyroid deficiency, and laboratory results. Dosage is typically titrated to achieve target thyroid‑stimulating hormone (TSH) levels.

Safety data for levothyroxine in pregnancy and lactation are limited, but the drug is often continued when benefits outweigh potential risks. Physicians usually monitor thyroid function closely and may adjust the dose to maintain maternal and fetal health.

To order L-Thyroxin 88, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any required import documentation.

L-Thyroxin 88 is a generic levothyroxine formulation comparable in efficacy and safety to brand‑name products such as Synthroid or Euthyrox. All contain the same active ingredient and are intended to provide consistent hormone replacement, though bioequivalence may vary slightly between manufacturers.

Store L-Thyroxin 88 at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

L-Thyroxin 88 is taken orally, usually once daily on an empty stomach, at least 30 minutes before breakfast. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed by a healthcare professional.

Serious risks include allergic reactions such as rash or anaphylaxis, cardiac events like chest pain or arrhythmia, severe bone loss leading to osteoporosis, and thyrotoxicosis if the dose becomes excessive. Prompt medical attention is required if any of these occur.

Patients with known hypersensitivity to levothyroxine or any tablet excipients should avoid L-Thyroxin 88. Caution is also advised for individuals with untreated adrenal insufficiency, recent myocardial infarction, or uncorrected severe cardiovascular disease, where thyroid hormone replacement may exacerbate conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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