Product image of L-Thyroxin Al (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin Al

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin Al (Levothyroxine Sodium)

Levothyroxine Sodium, the active ingredient in L-Thyroxin Al, is a thyroid hormone presented as a tablet for oral use. It replaces deficient thyroid hormone, helping to regulate metabolism, growth, and development. The medication is indicated for patients with hypothyroidism, goiter, and other thyroid hormone deficiencies, and is prescribed for both adult and pediatric populations requiring hormone replacement.

GNH India supplies L-Thyroxin Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with reliable quality assurance and regulatory compliance.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

L-Thyroxin Al is a synthetic thyroid hormone used to correct hormone deficits in disorders of the thyroid gland.

  • Hypothyroidism: restores normal thyroid hormone levels, relieving fatigue, weight gain, and cold intolerance.
  • Goiter: reduces thyroid-stimulating hormone drive, helping to shrink an enlarged thyroid.
  • Thyroid hormone deficiency: provides necessary thyroxine for patients lacking endogenous production, supporting metabolism and growth.

How It Works

  • Levothyroxine Sodium is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. The hormone binds to nuclear thyroid receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth. By replenishing deficient hormone, it normalizes the hypothalamic‑pituitary‑thyroid feedback loop.

Side Effects

Levothyroxine Sodium may cause a range of adverse reactions, most of which are dose‑related and reversible upon adjustment.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Nervousness or anxiety: heightened nervous system activity.
  • Weight loss: unintended reduction due to increased metabolism.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Gastrointestinal upset: nausea, vomiting, or abdominal discomfort.

Serious or Rare Side Effects

  • Cardiac arrhythmias: especially in patients with pre‑existing heart disease.
  • Osteoporosis: long‑term excess may reduce bone mineral density.
  • Allergic reactions: rash, pruritus, or angioedema.
  • Hyperthyroid symptoms: tremor, heat intolerance, or sweating.
  • Myopathy: muscle weakness or pain.
  • Severe chest pain: possible angina or myocardial ischemia.

Precautions & Warnings

Levothyroxine therapy requires careful monitoring and patient education.

  • Dose titration: adjust based on serum TSH and clinical response.
  • Cardiovascular disease: initiate at low dose and monitor heart rate.
  • Pregnancy and lactation: use only if benefits outweigh risks; monitor thyroid function closely.
  • Elderly patients: start with reduced dose to avoid overtreatment.
  • Drug interactions: review concomitant medications that may affect absorption or metabolism.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine absorption and activity can be altered by several co‑administered agents.

Major Interactions (Avoid)

  • Levothyroxine + calcium or iron supplements: markedly reduces absorption; separate dosing by at least 4 hours.
  • Levothyroxine + proton pump inhibitors: may decrease bioavailability; monitor thyroid function.
  • Levothyroxine + amiodarone: can cause thyroid dysfunction; require close monitoring.

Moderate Interactions (Monitor Closely)

  • Levothyroxine + warfarin: may enhance anticoagulant effect; check INR regularly.
  • Levothyroxine + antiepileptic drugs (e.g., phenytoin, carbamazepine): increase metabolism, possibly requiring dose increase.
  • Levothyroxine + glucocorticoids: may suppress TSH, necessitating dose adjustment.

Frequently Asked Questions

L-Thyroxin Al contains levothyroxine sodium, a synthetic thyroid hormone used to treat hypothyroidism, goiter, and other conditions where the body lacks sufficient thyroid hormone. It restores normal hormone levels, helping to regulate metabolism, energy, and growth.

Levothyroxine sodium is a pro‑hormone that is converted in the body to the active hormone triiodothyronine (T3). These hormones bind to nuclear thyroid receptors, influencing gene expression that controls basal metabolic rate, protein synthesis, and development, thereby compensating for deficient endogenous hormone.

The dose of L-Thyroxin Al is individualized. A qualified prescriber determines the appropriate amount based on the patient’s age, weight, severity of thyroid deficiency, and serum TSH levels, then adjusts the dose as needed during follow‑up.

Levothyroxine is generally considered safe in pregnancy and lactation when medically indicated, as untreated hypothyroidism can harm both mother and fetus. However, therapy should be guided by a healthcare professional who will monitor thyroid function and adjust dosing as required.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

L-Thyroxin Al provides levothyroxine sodium, the standard of care for thyroid hormone replacement. Compared with combination T4/T3 products, it offers a stable, predictable pharmacokinetic profile and is widely used as the first‑line therapy for hypothyroidism.

Store L-Thyroxin Al at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Keep the tablets in a dry place and avoid exposure to high humidity to maintain potency.

L-Thyroxin Al is taken orally, usually once daily on an empty stomach, preferably 30‑60 minutes before breakfast. The tablet should be swallowed whole with a glass of water; it should not be crushed or chewed.

Serious risks include cardiac arrhythmias, especially in patients with underlying heart disease, and excessive thyroid hormone levels leading to symptoms of hyperthyroidism such as tremor, rapid heart rate, and bone loss. Prompt medical review is essential if these occur.

L-Thyroxin Al should be avoided in individuals with known hypersensitivity to levothyroxine or any excipients, and used with caution in patients with untreated adrenal insufficiency, recent myocardial infarction, or uncorrected thyrotoxicosis. A healthcare professional must evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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