Product image of L-Thyroxin Berlin-Chemie (Levothyroxine Sodium, Hydrate) supplied by GNH India

L-Thyroxin Berlin-Chemie

Active Ingredient:
Levothyroxine Sodium, Hydrate
Origin:
EU

L-Thyroxin Berlin-Chemie (Levothyroxine Sodium, Hydrate)

Levothyroxine Sodium, the active ingredient in L-Thyroxin Berlin-Chemie, is a thyroid hormone presented as an oral tablet for oral use. It replaces deficient thyroid hormone and restores normal metabolic activity in patients with hypothyroidism or after thyroid removal, and is indicated for long‑term management of thyroid hormone deficiency.

GNH India supplies L-Thyroxin Berlin-Chemie as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant documentation for export to global markets.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Levothyroxine is used to treat conditions caused by insufficient thyroid hormone production.

  • Hypothyroidism: restores normal thyroid hormone levels and alleviates symptoms such as fatigue, weight gain, and cold intolerance.
  • Post‑thyroidectomy replacement: provides the necessary hormone after surgical removal of the thyroid gland.
  • Goiter associated with hypothyroidism: reduces gland enlargement by normalizing hormone feedback.

How It Works

  • Levothyroxine is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is transported in plasma bound to thyroid‑binding globulin and converted by peripheral deiodinases into the active hormone triiodothyronine (T3). The resulting T3 binds nuclear thyroid receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth. This physiological replacement normalizes the feedback loop with the pituitary gland, thereby stabilizing thyroid‑stimulating hormone (TSH) secretion.

Side Effects

Levothyroxine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate headache may occur.
  • Insomnia: difficulty sleeping.
  • Palpitations: awareness of heartbeats.
  • Weight loss: unintended loss of weight.
  • Heat intolerance: increased sensitivity to warm environments.

Serious or Rare Side Effects

  • Angina pectoris: chest pain indicating myocardial ischemia.
  • Atrial fibrillation: irregular rapid heart rhythm.
  • Osteoporosis: decreased bone mineral density with long‑term overtreatment.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating levothyroxine therapy, several precautions should be considered to ensure safe and effective use.

  • Cardiovascular disease: assess heart condition as excess hormone may precipitate angina or arrhythmia.
  • Elderly patients: start with lower dose and titrate slowly to avoid cardiac stress.
  • Adrenal insufficiency: ensure adequate glucocorticoid replacement before therapy.
  • Pregnancy and lactation: use only if clearly needed; monitor thyroid function closely.
  • Monitoring: check serum TSH and free T4 levels regularly to adjust dose.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levothyroxine interacts with several medicines that can alter its absorption or pharmacodynamic effect.

Major Interactions (Avoid)

  • Anticoagulants (warfarin): may increase INR, requiring closer monitoring.
  • Insulin and oral hypoglycemics: enhanced hypoglycemic effect.
  • Digoxin: increased serum levels may occur.
  • Estrogen‑containing contraceptives: may increase levothyroxine requirement.

Moderate Interactions (Monitor Closely)

  • Calcium or iron supplements: reduce levothyroxine absorption; separate dosing by at least 4 hours.
  • Proton pump inhibitors and H2‑blockers: may decrease absorption, monitor thyroid function.
  • Cholestyramine or other bile‑acid sequestrants: lower levothyroxine bioavailability.

Frequently Asked Questions

L-Thyroxin Berlin-Chemie contains levothyroxine sodium, a synthetic thyroid hormone used to replace deficient thyroid hormone in patients with hypothyroidism, after total or partial thyroidectomy, and in cases of goiter associated with low thyroid function.

Levothyroxine is absorbed from the gastrointestinal tract, binds to plasma proteins, and is converted to the active hormone triiodothyronine (T3) in peripheral tissues. T3 then binds nuclear thyroid receptors, regulating gene expression that controls metabolism, growth, and development.

The appropriate dose of levothyroxine is individualized. A qualified prescriber determines the starting dose based on the patient’s age, weight, cardiac status, and laboratory thyroid function tests, and then adjusts it to maintain target TSH levels.

Levothyroxine is classified as a pregnancy‑category drug where the benefits may outweigh potential risks. It is commonly continued in pregnancy to maintain maternal euthyroidism, which is essential for fetal development. Breastfeeding mothers should also discuss continuation with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

L-Thyroxin Berlin-Chemie is a generic levothyroxine formulation comparable in efficacy and safety to other branded products such as Synthroid or Eltroxin. Differences may lie in excipients, tablet size, or manufacturing standards, but the active ingredient and therapeutic effect remain equivalent when dosed appropriately.

Store the tablets at room temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Do not refrigerate or freeze. Keep out of reach of children and dispose of any expired product according to local regulations.

The medication is taken orally, usually on an empty stomach 30‑60 minutes before breakfast with a full glass of water. Swallow the tablet whole; do not crush or chew it, as this may affect absorption.

Serious risks include cardiac events such as angina or atrial fibrillation, especially in patients with pre‑existing heart disease, and bone loss (osteoporosis) with long‑term overtreatment. Severe allergic reactions, though rare, may also occur and require immediate medical attention.

Levothyroxine should be avoided in individuals with untreated adrenal insufficiency, acute myocardial infarction, or untreated thyrotoxicosis. Patients with known hypersensitivity to levothyroxine or any tablet excipients should also refrain from using this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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