Product image of L-Thyroxin Berlin-Chemie (Levothyroxine Sodium, Hydrate) supplied by GNH India

L-Thyroxin Berlin-Chemie

Active Ingredient:
Levothyroxine Sodium, Hydrate
Origin:
EU

L-Thyroxin Berlin-Chemie (Levothyroxine Sodium, Hydrate)

Levothyroxine sodium, the active ingredient in L-Thyroxin Berlin-Chemie, is a thyroid hormone presented as a tablet for oral use. It restores normal metabolic activity by replacing or supplementing endogenous thyroxine (T4) in individuals diagnosed with hypothyroidism, including those with goiter or who require thyroid hormone replacement after thyroidectomy. The medication is indicated for long‑term management of thyroid hormone deficiency and is administered under medical supervision.

GNH India supplies L-Thyroxin Berlin-Chemie as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Levothyroxine sodium is used to treat conditions related to deficient thyroid hormone production.

  • Hypothyroidism: Restores normal thyroid hormone levels, improving metabolic rate and symptom control.
  • Post‑thyroidectomy hormone replacement: Provides necessary thyroxine after surgical removal of the thyroid gland.
  • Goiter associated with hypothyroidism: Reduces gland enlargement by normalizing hormone feedback.

How It Works

  • Levothyroxine sodium is a synthetic form of the endogenous thyroid hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues, binding to nuclear thyroid hormone receptors and regulating gene transcription that controls basal metabolic rate, protein synthesis, and growth. By replenishing deficient hormone levels, it normalizes the hypothalamic‑pituitary‑thyroid axis.

Side Effects

Adverse reactions may occur with levothyroxine therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Insomnia: difficulty falling or staying asleep.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Weight loss: unintended reduction in body weight.
  • Tremor: fine shaking of hands or limbs.
  • Heat intolerance: increased sensitivity to warm environments.

Serious or Rare Side Effects

  • Cardiac arrhythmia: potentially life‑threatening rhythm disturbances.
  • Angina or myocardial infarction: chest pain or heart attack in susceptible patients.
  • Osteoporosis: decreased bone mineral density with long‑term overtreatment.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Adrenal crisis: precipitated in patients with adrenal insufficiency.
  • Hyperthyroid symptoms: severe over‑replacement leading to thyrotoxicosis.

Precautions & Warnings

Levothyroxine requires careful monitoring and individualized dosing.

  • Dose adjustment: regularly assess TSH and free T4 levels to fine‑tune therapy.
  • Cardiovascular disease: initiate at low dose and titrate slowly to avoid cardiac stress.
  • Pregnancy: use only when benefits outweigh potential risks; monitor maternal thyroid status closely.
  • Elderly patients: consider reduced starting dose due to altered metabolism.
  • Drug interactions: review concomitant medications that may affect absorption or hormone levels.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levothyroxine may interact with several medicines, affecting its absorption or hormonal activity.

Major Interactions (Avoid)

  • Calcium supplements: significantly reduce levothyroxine absorption; separate dosing by at least 4 hours.
  • Iron salts: impair absorption; administer at different times.
  • Antacids containing aluminum or magnesium: decrease bioavailability; avoid concurrent intake.

Moderate Interactions (Monitor Closely)

  • Warfarin: levothyroxine can alter INR; monitor coagulation parameters.
  • Amiodarone: may affect thyroid function tests; adjust levothyroxine dose as needed.
  • Selective serotonin reuptake inhibitors (SSRIs): may require dose modification based on thyroid status.

Frequently Asked Questions

L-Thyroxin Berlin-Chemie contains levothyroxine sodium and is prescribed to replace or supplement thyroid hormone in patients with hypothyroidism, to provide hormone replacement after thyroidectomy, and to manage goiter associated with low thyroid function.

Levothyroxine sodium is a synthetic form of thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues, binds to nuclear thyroid receptors, and regulates gene expression that controls metabolism, growth, and development.

The appropriate dose is individualized and determined by the prescribing clinician based on the patient’s thyroid function tests, age, weight, cardiac status, and other clinical factors. Patients should follow the dose prescribed by their healthcare professional.

Levothyroxine is the treatment of choice for hypothyroidism in pregnancy and lactation when indicated. It should be used only when the expected benefit justifies any potential risk, and thyroid function should be closely monitored throughout pregnancy and while nursing.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

L-Thyroxin Berlin-Chemie is a generic levothyroxine formulation comparable in potency and bioavailability to other branded or generic levothyroxine products. Differences may exist in excipients, tablet hardness, or dissolution profile, which can affect individual tolerability and absorption.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually on an empty stomach, at least 30 minutes before breakfast or any other medication. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed by a healthcare professional.

Serious risks include cardiac arrhythmias, angina or myocardial infarction in patients with underlying heart disease, severe osteoporosis with long‑term overtreatment, and rare allergic reactions. Prompt medical attention is required if symptoms such as chest pain, rapid heartbeat, or severe bone pain occur.

Patients with known hypersensitivity to levothyroxine or any tablet excipients should avoid the product. Caution is advised in individuals with untreated adrenal insufficiency, recent myocardial infarction, or uncorrected thyrotoxicosis, as levothyroxine may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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