Product image of L-Thyroxin Henning (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin Henning

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin Henning (Levothyroxine Sodium)

Levothyroxine Sodium, the active ingredient in L-Thyroxin Henning, is a thyroid hormone replacement presented as a tablet for oral use. It treats hypothyroidism and replaces deficient thyroid hormone in patients with thyroid insufficiency.

GNH India supplies L-Thyroxin Henning as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

L-Thyroxin Henning is a synthetic thyroid hormone that acts on the endocrine system to restore normal metabolic activity. It is indicated for:

  • Hypothyroidism: normalizes thyroid hormone levels and alleviates symptoms such as fatigue and weight gain.
  • Post‑thyroidectomy hormone replacement: provides the missing thyroxine after surgical removal of the thyroid gland.
  • Goiter: helps reduce gland enlargement by correcting hormonal imbalance.

How It Works

  • Levothyroxine Sodium is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. The hormone binds to nuclear thyroid receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth. By restoring circulating thyroid hormone concentrations, it normalizes metabolic processes that are deficient in hypothyroid states.

Side Effects

Adverse reactions may occur with levothyroxine therapy. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Headache: mild to moderate headache may develop.
  • Insomnia: difficulty sleeping is reported in some individuals.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Weight loss: unintended loss of weight due to increased metabolism.
  • Heat intolerance: feeling unusually warm or sweaty.
  • Tremor: fine shaking of the hands.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or swelling indicating hypersensitivity.
  • Angioedema: rapid swelling of face, lips, or tongue requiring urgent care.
  • Chest pain: possible sign of cardiac ischemia.
  • Arrhythmia: abnormal heart rhythm, especially in patients with pre‑existing heart disease.
  • Osteoporosis: long‑term excess may reduce bone density.
  • Adrenal insufficiency exacerbation: can precipitate adrenal crisis if untreated.

Precautions & Warnings

Levothyroxine requires careful monitoring to ensure safe and effective therapy.

  • Dose adjustment in elderly: start with lower doses and titrate slowly.
  • Monitor thyroid function tests: regularly assess TSH and free T4 levels.
  • Avoid use in untreated adrenal insufficiency: may precipitate adrenal crisis.
  • Caution in cardiovascular disease: excess hormone can increase heart workload.
  • Pregnancy considerations: dose may need adjustment; discuss with a healthcare professional.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine may interact with several medicines, altering its absorption or effect.

Major Interactions (Avoid)

  • Calcium supplements: reduce levothyroxine absorption.
  • Iron salts: markedly decrease oral bioavailability.
  • Cholestyramine or colestipol: bind the hormone and limit uptake.
  • Sucralfate: interferes with absorption when taken concurrently.
  • Antacids containing aluminum or magnesium: diminish effectiveness.

Moderate Interactions (Monitor Closely)

  • Warfarin: levothyroxine may enhance anticoagulant effect.
  • Diabetes medications: thyroid hormone can affect glucose control.
  • Estrogen therapy: may increase levothyroxine requirement.
  • Antidepressants (SSRIs): potential alteration of thyroid hormone levels.
  • Statins: possible modest impact on thyroid function tests.

Frequently Asked Questions

L-Thyroxin Henning contains levothyroxine sodium, a synthetic thyroid hormone used to treat hypothyroidism, provide hormone replacement after thyroidectomy, and manage goiter caused by thyroid hormone deficiency. By restoring normal thyroid hormone levels, it helps alleviate symptoms such as fatigue, weight gain, and cold intolerance.

Levothyroxine sodium is a synthetic form of thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. These hormones bind to nuclear thyroid receptors, regulating gene expression that controls metabolism, growth, and development, thereby correcting the hormonal deficit seen in hypothyroid states.

The appropriate dose of L-Thyroxin Henning is individualized and set by a prescriber based on factors such as age, weight, severity of hypothyroidism, and laboratory results. Dosage may be adjusted over time to maintain target thyroid‑stimulating hormone (TSH) levels, and patients should follow the prescribing clinician’s instructions.

Levothyroxine is generally considered safe in pregnancy and breastfeeding when medically indicated, as untreated hypothyroidism can harm both mother and fetus. However, dose adjustments are often required during pregnancy. Women who are pregnant, planning pregnancy, or nursing should discuss therapy with their healthcare provider for appropriate monitoring.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the enquiry, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

L-Thyroxin Henning is a levothyroxine sodium formulation, the same active ingredient found in other brand‑name and generic thyroid hormone products. All levothyroxine preparations aim to replace deficient T4. Differences may lie in excipients, tablet hardness, or bioavailability, but clinical efficacy is comparable when dosing is appropriately adjusted.

Store L-Thyroxin Henning tablets at room temperature, below 25 °C. Keep the product in its original packaging to protect it from moisture and light. Do not store in bathrooms or near heat sources, and ensure the container is tightly closed to maintain tablet integrity.

L-Thyroxin Henning is taken orally, usually on an empty stomach, at least 30 minutes before breakfast or other medications. Swallow the tablet whole with a glass of water. Consistency in timing and food intake helps maintain stable absorption and optimal thyroid hormone levels.

Serious risks include allergic reactions such as rash, angioedema, or anaphylaxis, and cardiac events like arrhythmias or chest pain, especially in patients with underlying heart disease. Over‑replacement can lead to symptoms of hyperthyroidism, including bone loss (osteoporosis) and adrenal insufficiency exacerbation. Prompt medical attention is required if any severe symptoms develop.

L-Thyroxin Henning should be avoided in individuals with known hypersensitivity to levothyroxine sodium or any tablet excipients. It is also contraindicated in patients with untreated adrenal insufficiency, as thyroid hormone replacement can precipitate an adrenal crisis. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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