Product image of L-Thyroxin Inject Henning (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin Inject Henning

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin Inject Henning (Levothyroxine Sodium)

Levothyroxine sodium, the active ingredient in L-Thyroxin Inject Henning, is a thyroid hormone presented as an injectable solution for intravenous use. It replaces deficient thyroid hormone in patients with hypothyroidism and provides rapid hormone replacement in myxedema coma, and helps normalize metabolic processes. The formulation is sterile and designed for hospital administration under professional supervision.

GNH India supplies L-Thyroxin Inject Henning as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics, and pharmacies worldwide, ensuring reliable delivery across global markets with quality assurance.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Levothyroxine sodium is used as thyroid hormone replacement therapy to correct hormone deficiency in several clinical conditions.

  • Hypothyroidism: restores normal thyroid hormone levels, improving metabolism and alleviating symptoms such as fatigue and weight gain.
  • Myxedema coma: provides rapid intravenous hormone replacement to reverse life‑threatening metabolic collapse.
  • Thyroid hormone replacement therapy: maintains euthyroid state in patients after thyroidectomy or radioactive iodine treatment.

How It Works

  • Levothyroxine sodium is a synthetic form of the endogenous hormone thyroxine (T4). After intravenous administration, it is converted to the active hormone triiodothyronine (T3) within peripheral tissues. T3 binds nuclear thyroid hormone receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth. This restores normal metabolic activity in patients lacking sufficient endogenous thyroid hormone.

Side Effects

Levothyroxine sodium may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache
  • Nausea or vomiting
  • Transient fever or chills
  • Mild tachycardia

Serious or Rare Side Effects

  • Anaphylaxis
  • Angioedema
  • Severe arrhythmias (e.g., atrial fibrillation)
  • Myocardial infarction

Precautions & Warnings

When using L-Thyroxin Inject Henning, consider the following precautions.

  • Dose adjustment: Reduce dose in elderly patients or those with cardiovascular disease.
  • Cardiac monitoring: Observe for tachyarrhythmias during initiation, especially in patients with coronary artery disease.
  • Adrenal insufficiency: Do not initiate therapy in untreated adrenal insufficiency; supplement glucocorticoids first.
  • Thyroid function testing: Verify TSH and free T4 levels before and after treatment to avoid over‑replacement.
  • Contraindication: Avoid use in acute myocardial infarction until stabilized.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levothyroxine sodium can interact with several medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., methimazole, propylthiouracil): antagonize levothyroxine effect.
  • Estrogen therapy or oral contraceptives: increase levothyroxine requirement.
  • Amiodarone: alters thyroid hormone metabolism, may require dose adjustment.

Moderate Interactions (Monitor Closely)

  • Calcium or iron supplements administered intravenously: may reduce levothyroxine activity.
  • Beta‑blockers: may mask symptoms of excess thyroid hormone.
  • Warfarin: levothyroxine can affect INR, requiring closer monitoring.

Frequently Asked Questions

L-Thyroxin Inject Henning is an intravenous levothyroxine sodium preparation used to replace deficient thyroid hormone in patients with hypothyroidism and to provide rapid hormone replacement in emergency situations such as myxedema coma.

Levothyroxine sodium is a synthetic form of thyroxine (T4). After administration it is converted to the active hormone triiodothyronine (T3), which binds nuclear thyroid hormone receptors and regulates gene transcription, thereby normalizing metabolism and protein synthesis in the body.

The appropriate dose is individualized and set by the prescribing clinician based on the patient’s age, weight, severity of thyroid deficiency, cardiac status, and laboratory measurements of thyroid function. No fixed dosing regimen is provided here.

The pregnancy safety category for levothyroxine sodium is not definitively established for this injectable form. Use during pregnancy or lactation should be based on a careful risk‑benefit assessment by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and necessary import documentation.

The injectable form delivers levothyroxine directly into the bloodstream, allowing rapid correction of hormone levels, which is essential in acute settings such as myxedema coma. Oral levothyroxine is taken daily for routine maintenance and has a slower onset of action. Both provide the same active hormone but differ in route, speed of effect, and clinical indications.

The product should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Follow the manufacturer’s instructions for handling to maintain stability and potency.

L-Thyroxin Inject Henning is administered by a qualified healthcare professional as an intravenous injection. The dose is prepared according to aseptic technique and given slowly, typically in a hospital or clinical setting, with monitoring of vital signs.

Serious risks include anaphylactic reactions, angioedema, severe cardiac arrhythmias such as atrial fibrillation, and myocardial infarction. Patients should be monitored closely for signs of hypersensitivity or cardiac complications, especially during the initial infusion.

The product should be avoided in individuals with known hypersensitivity to levothyroxine or any excipients, in patients with untreated adrenal insufficiency, and in those experiencing an acute myocardial infarction until the condition is stabilized.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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